Reagentless biosensor based on layer-by-layer assembly of functional multiwall carbon nanotubes and enzyme-mediator biocomposite Article Swipe
Xinghua Zhou
,
Fengna Xi
,
Yiming Zhang
,
Xianfu Lin
·
YOU?
·
· 2011
· Open Access
·
· DOI: https://doi.org/10.1631/jzus.b1000280
YOU?
·
· 2011
· Open Access
·
· DOI: https://doi.org/10.1631/jzus.b1000280
A simple and controllable layer-by-layer (LBL) assembly method was proposed for the construction of reagentless biosensors based on electrostatic interaction between functional multiwall carbon nanotubes (MWNTs) and enzyme-mediator biocomposites. The carboxylated MWNTs were wrapped with polycations poly(allylamine hydrochloride) (PAH) and the resulting PAH-MWNTs were well dispersed and positively charged. As a water-soluble dye methylene blue (MB) could mix well with horseradish peroxidase (HRP) to form a biocompatible and negatively-charged HRP-MB biocomposite. A (PAH-MWNTs/HRP-MB)(n) bionanomultilayer was then prepared by electrostatic LBL assembly of PAH-MWNTs and HRP-MB on a polyelectrolyte precursor film-modified Au electrode. Due to the excellent biocompatibility of HRP-MB biocomposite and the uniform LBL assembly, the immobilized HRP could retain its natural bioactivity and MB could efficiently shuttle electrons between HRP and the electrode. The incorporation of MWNTs in the bionanomultilayer enhanced the surface coverage concentration of the electroactive enzyme and increased the catalytic current response of the electrode. The proposed biosensor displayed a fast response (2 s) to hydrogen peroxide with a low detection limit of 2.0×10⁻⁷ mol/L (S/N=3). This work provided a versatile platform in the further development of reagentless biosensors.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1631/jzus.b1000280
- https://link.springer.com/content/pdf/10.1631/jzus.B1000280.pdf
- OA Status
- bronze
- Cited By
- 8
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2062430612
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2062430612Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1631/jzus.b1000280Digital Object Identifier
- Title
-
Reagentless biosensor based on layer-by-layer assembly of functional multiwall carbon nanotubes and enzyme-mediator biocompositeWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2011Year of publication
- Publication date
-
2011-06-01Full publication date if available
- Authors
-
Xinghua Zhou, Fengna Xi, Yiming Zhang, Xianfu LinList of authors in order
- Landing page
-
https://doi.org/10.1631/jzus.b1000280Publisher landing page
- PDF URL
-
https://link.springer.com/content/pdf/10.1631/jzus.B1000280.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://link.springer.com/content/pdf/10.1631/jzus.B1000280.pdfDirect OA link when available
- Concepts
-
Biocomposite, Carbon nanotube, Biosensor, Nanotechnology, Materials science, Layer (electronics), Mediator, Layer by layer, Chemical engineering, Composite material, Biology, Composite number, Engineering, Cell biologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1, 2021: 1, 2019: 1, 2017: 1, 2015: 1Per-year citation counts (last 5 years)
- References (count)
-
29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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