Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor Article Swipe
Jamie R. K. Marland
,
Mark Gray
,
Camelia Dunare
,
Ewen O. Blair
,
Andreas Tsiamis
,
P. J. Sullivan
,
Eva González‐Fernández
,
Stephen N. Greenhalgh
,
Rachael Gregson
,
R. Eddie Clutton
,
Magdalena Parys
,
Alex Dyson
,
Mervyn Singer
,
Ian Kunkler
,
Mark A. Potter
,
Srinjoy Mitra
,
Jonathan G. Terry
,
Stewart Smith
,
Andrew R. Mount
,
Ian Underwood
,
A.J. Walton
,
David J. Argyle
,
Alan F. Murray
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.sbsr.2020.100375
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1016/j.sbsr.2020.100375
Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor for real-time monitoring of tissue oxygenation that could enable this novel treatment approach to be implemented. The sensor uses a solid-state electrochemical cell that was microfabricated at wafer level on a silicon substrate, and includes an integrated reference electrode and electrolyte membrane. It gave a linear response to oxygen concentration, and was unaffected by sterilisation and irradiation, but showed susceptibility to biofouling. Oxygen selectivity was also evaluated against various clinically relevant electroactive compounds. We investigated its robustness and functionality under realistic clinical conditions using a sheep model of lung cancer. The sensor remained functional following CT-guided tumour implantation, and was sufficiently sensitive to track acute changes in oxygenation within tumour tissue.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.sbsr.2020.100375
- OA Status
- gold
- Cited By
- 41
- References
- 71
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3048934001Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.sbsr.2020.100375Digital Object Identifier
- Title
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Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensorWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-08-11Full publication date if available
- Authors
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Jamie R. K. Marland, Mark Gray, Camelia Dunare, Ewen O. Blair, Andreas Tsiamis, P. J. Sullivan, Eva González‐Fernández, Stephen N. Greenhalgh, Rachael Gregson, R. Eddie Clutton, Magdalena Parys, Alex Dyson, Mervyn Singer, Ian Kunkler, Mark A. Potter, Srinjoy Mitra, Jonathan G. Terry, Stewart Smith, Andrew R. Mount, Ian Underwood, A.J. Walton, David J. Argyle, Alan F. MurrayList of authors in order
- Landing page
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https://doi.org/10.1016/j.sbsr.2020.100375Publisher landing page
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.sbsr.2020.100375Direct OA link when available
- Concepts
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Oxygen sensor, Hypoxia (environmental), Oxygen, Biomedical engineering, Materials science, Electrolyte, Wafer, Electrode, Chemistry, Optoelectronics, Medicine, Physical chemistry, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
41Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 5, 2023: 10, 2022: 14, 2021: 10Per-year citation counts (last 5 years)
- References (count)
-
71Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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