Real-World Analysis of the Clinical and Economic Impact of the 21-Gene Recurrence Score (RS) in Invasive Lobular Early-Stage Breast Carcinoma in Ireland Article Swipe
Lynda McSorley
,
Mehala Tharmabala
,
Fathiya Al Rahbi
,
Fergus Keane
,
Denis Evoy
,
James Geraghty
,
Jane Rothwell
,
Damian McCartan
,
Megan Greally
,
Miriam O’Connor
,
Deirdre O’Mahony
,
Maccon Keane
,
Michael J. Kennedy
,
Séamus O’Reilly
,
Steve Millen
,
John Crown
,
Catherine M. Kelly
,
Ruth Prichard
,
Cecily Quinn
,
Janice M. Walshe
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/curroncol31030098
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/curroncol31030098
Background: This study, using real-world data, assesses the impact of RS testing on treatment pathways and the associated economic consequences of such testing. This paper pertains to lobular breast cancer. Methods: A retrospective, observational study was undertaken between 2011 and 2019 on a cross-section of hormone receptor-positive (HR+), HER2-negative, lymph node-negative, early-stage breast cancer patients. All patients had ILC and had RS testing in Ireland. The patient population is representative of the national population. Patients were classified as low (RS ≤ 25) or high (RS > 25) risk. Patients aged ≤50 were stratified as low (RS 0–15), intermediate (RS 16–25), or high risk (RS > 25). Results: A total of 168 patients were included, most of whom had grade 2 (G2) tumors (n = 154, 92%). Overall, 155 patients (92.3%) had low RS (≤25), 12 (7.1%) had high RS (>25), and 1 (0.6%) had unknown RS status. In 29 (17.5%) patients aged ≤50 at diagnosis, RS was ≤15 in 16 (55%), 16–20 in 6 (21%), 21–25 in 5 (17%), >25 in 1 (3.5%), and unknown in 1 (3.5%). Post RS testing, 126 patients (78%) had a change in chemotherapy recommendation; all to hormone therapy. In total, only 35 patients (22%) received chemotherapy. RS testing achieved a 75% reduction in chemotherapy use, resulting in savings of €921,543.84 in treatment costs, and net savings of €387,283.84. Conclusions: The use of this test resulted in a 75% reduction in chemotherapy and a significant cost savings in our publicly funded health system.
Related Topics
Concepts
Medicine
Breast cancer
Internal medicine
Stage (stratigraphy)
Chemotherapy
Population
Hormone therapy
Oncology
Breast carcinoma
Cancer
Observational study
Invasive lobular carcinoma
Lymph node
Gastroenterology
Paleontology
Invasive ductal carcinoma
Environmental health
Biology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/curroncol31030098
- https://www.mdpi.com/1718-7729/31/3/98/pdf?version=1709254677
- OA Status
- gold
- Cited By
- 1
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392361470
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4392361470Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/curroncol31030098Digital Object Identifier
- Title
-
Real-World Analysis of the Clinical and Economic Impact of the 21-Gene Recurrence Score (RS) in Invasive Lobular Early-Stage Breast Carcinoma in IrelandWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-01Full publication date if available
- Authors
-
Lynda McSorley, Mehala Tharmabala, Fathiya Al Rahbi, Fergus Keane, Denis Evoy, James Geraghty, Jane Rothwell, Damian McCartan, Megan Greally, Miriam O’Connor, Deirdre O’Mahony, Maccon Keane, Michael J. Kennedy, Séamus O’Reilly, Steve Millen, John Crown, Catherine M. Kelly, Ruth Prichard, Cecily Quinn, Janice M. WalsheList of authors in order
- Landing page
-
https://doi.org/10.3390/curroncol31030098Publisher landing page
- PDF URL
-
https://www.mdpi.com/1718-7729/31/3/98/pdf?version=1709254677Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1718-7729/31/3/98/pdf?version=1709254677Direct OA link when available
- Concepts
-
Medicine, Breast cancer, Internal medicine, Stage (stratigraphy), Chemotherapy, Population, Hormone therapy, Oncology, Breast carcinoma, Cancer, Observational study, Invasive lobular carcinoma, Lymph node, Gastroenterology, Paleontology, Invasive ductal carcinoma, Environmental health, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- References (count)
-
21Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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