Real‐life study on the pharmacokinetic of remdesivir in ICU patients admitted for severe COVID‐19 pneumonia Article Swipe
Silvia Corcione
,
Amedeo De Nicolò
,
Giorgia Montrucchio
,
Silvia Scabini
,
Valeria Avataneo
,
Chiara Bonetto
,
Simone Mornese Pinna
,
Jessica Cusato
,
Francesca Canta
,
Rosario Urbino
,
Giovanni Di Perri
,
Luca Brazzi
,
Francesco Giuseppe De Rosa
,
Antonio D’Avolio
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/bcp.14895
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/bcp.14895
Remdesivir is one of the most encouraging treatments against SARS‐CoV‐2 infection. After intravenous infusion, RDV is rapidly metabolized ( t 1/2 = 1 h) within the cells to its active adenosine triphosphate analogue form (GS‐443902) and then it can be found in plasma in its nucleoside analogue form (GS‐441524). In this real‐life study, we describe the remdesivir and GS‐441524 concentrations at three time points in nine ICU patients, through a validated ultra‐high‐performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) method. The observed data confirmed the very rapid conversion of RDV to its metabolite and the quite long half‐life of GS‐441524. The mean C min , C max and AUC 0–24 , were < 0.24 ng/mL and 122.3 ng/mL, 2637.3 ng/mL and 157.8 ng/mL, and 5171.2 ng*h/mL and 3676.5 ng*h/ml, respectively, for RDV and GS‐441524. Three out of nine patients achieved a C max > 2610 ng/mL and 140 ng/mL and AUC 0–24 > 1560 ng*h/mL and 2230 ng*h/mL for RDV and GS‐441524, respectively. The mean t 1/2 value for GS‐441524 was 26.3 h. Despite the low number of patients, these data can represent an interesting preliminary report on the variability of RDV and GS‐441524 concentrations in a real‐life ICU setting.
Related Topics
Concepts
Cmax
Pharmacokinetics
Metabolite
Medicine
Pneumonia
Coronavirus disease 2019 (COVID-19)
Half-life
Cmin
Pharmacology
Internal medicine
Chromatography
Chemistry
Infectious disease (medical specialty)
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/bcp.14895
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14895
- OA Status
- bronze
- Cited By
- 11
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3160812158
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3160812158Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/bcp.14895Digital Object Identifier
- Title
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Real‐life study on the pharmacokinetic of remdesivir in ICU patients admitted for severe COVID‐19 pneumoniaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-05-15Full publication date if available
- Authors
-
Silvia Corcione, Amedeo De Nicolò, Giorgia Montrucchio, Silvia Scabini, Valeria Avataneo, Chiara Bonetto, Simone Mornese Pinna, Jessica Cusato, Francesca Canta, Rosario Urbino, Giovanni Di Perri, Luca Brazzi, Francesco Giuseppe De Rosa, Antonio D’AvolioList of authors in order
- Landing page
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https://doi.org/10.1111/bcp.14895Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14895Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bcp.14895Direct OA link when available
- Concepts
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Cmax, Pharmacokinetics, Metabolite, Medicine, Pneumonia, Coronavirus disease 2019 (COVID-19), Half-life, Cmin, Pharmacology, Internal medicine, Chromatography, Chemistry, Infectious disease (medical specialty), DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
11Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 1, 2023: 2, 2022: 3, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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27Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.achieved | 138 |
| abstract_inverted_index.analogue | 32, 46 |
| abstract_inverted_index.describe | 54 |
| abstract_inverted_index.ng*h/ml, | 127 |
| abstract_inverted_index.observed | 80 |
| abstract_inverted_index.patients | 137 |
| abstract_inverted_index.setting. | 198 |
| abstract_inverted_index.adenosine | 30 |
| abstract_inverted_index.confirmed | 82 |
| abstract_inverted_index.infusion, | 13 |
| abstract_inverted_index.patients, | 67, 177 |
| abstract_inverted_index.represent | 181 |
| abstract_inverted_index.validated | 70 |
| abstract_inverted_index.Remdesivir | 0 |
| abstract_inverted_index.conversion | 86 |
| abstract_inverted_index.infection. | 10 |
| abstract_inverted_index.metabolite | 91 |
| abstract_inverted_index.nucleoside | 45 |
| abstract_inverted_index.remdesivir | 56 |
| abstract_inverted_index.treatments | 7 |
| abstract_inverted_index.GS‐441524 | 58, 168, 192 |
| abstract_inverted_index.encouraging | 6 |
| abstract_inverted_index.half‐life | 96 |
| abstract_inverted_index.interesting | 183 |
| abstract_inverted_index.intravenous | 12 |
| abstract_inverted_index.metabolized | 17 |
| abstract_inverted_index.preliminary | 184 |
| abstract_inverted_index.real‐life | 51, 196 |
| abstract_inverted_index.variability | 188 |
| abstract_inverted_index.GS‐441524, | 160 |
| abstract_inverted_index.GS‐441524. | 98, 132 |
| abstract_inverted_index.spectrometry | 76 |
| abstract_inverted_index.triphosphate | 31 |
| abstract_inverted_index.(GS‐443902) | 34 |
| abstract_inverted_index.respectively, | 128 |
| abstract_inverted_index.respectively. | 161 |
| abstract_inverted_index.(GS‐441524). | 48 |
| abstract_inverted_index.SARS‐CoV‐2 | 9 |
| abstract_inverted_index.chromatography | 73 |
| abstract_inverted_index.concentrations | 59, 193 |
| abstract_inverted_index.(UHPLC–MS/MS) | 77 |
| abstract_inverted_index.ultra‐high‐performance | 71 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5036097214 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I121934306, https://openalex.org/I55143463 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/12 |
| sustainable_development_goals[0].score | 0.49000000953674316 |
| sustainable_development_goals[0].display_name | Responsible consumption and production |
| citation_normalized_percentile.value | 0.68530224 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |