Real‐time field‐programmable gate array‐based closed‐loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxia Article Swipe
Gajendra Kumar
,
Zhanhong Zhou
,
Wang Zh
,
Kin Ming Kwan
,
Chung Tin
,
Chi Him Eddie
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/cns.14638
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/cns.14638
Aims The open‐loop nature of conventional deep brain stimulation (DBS) produces continuous and excessive stimulation to patients which contributes largely to increased prevalence of adverse side effects. Cerebellar ataxia is characterized by abnormal Purkinje cells (PCs) dendritic arborization, loss of PCs and motor coordination, and muscle weakness with no effective treatment. We aim to develop a real‐time field‐programmable gate array (FPGA) prototype targeting the deep cerebellar nuclei (DCN) to close the loop for ataxia using conditional double knockout mice with deletion of PC‐specific LIM homeobox (Lhx)1 and Lhx5, resulting in abnormal dendritic arborization and motor deficits. Methods We implanted multielectrode array in the DCN and muscles of ataxia mice. The beneficial effect of open‐loop DCN‐DBS or closed‐loop DCN‐DBS was compared by motor behavioral assessments, electromyography (EMG), and neural activities (neurospike and electroencephalogram) in freely moving mice. FPGA board, which performed complex real‐time computation, was used for closed‐loop DCN‐DBS system. Results Closed‐loop DCN‐DBS was triggered only when symptomatic muscle EMG was detected in a real‐time manner, which restored motor activities, electroencephalogram activities and neurospike properties completely in ataxia mice. Closed‐loop DCN‐DBS was more effective than an open‐loop paradigm as it reduced the frequency of DBS. Conclusion Our real‐time FPGA‐based DCN‐DBS system could be a potential clinical strategy for alleviating cerebellar ataxia and other movement disorders.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/cns.14638
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14638
- OA Status
- gold
- Cited By
- 6
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392888565
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392888565Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/cns.14638Digital Object Identifier
- Title
-
Real‐time field‐programmable gate array‐based closed‐loop deep brain stimulation platform targeting cerebellar circuitry rescues motor deficits in a mouse model of cerebellar ataxiaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-01Full publication date if available
- Authors
-
Gajendra Kumar, Zhanhong Zhou, Wang Zh, Kin Ming Kwan, Chung Tin, Chi Him EddieList of authors in order
- Landing page
-
https://doi.org/10.1111/cns.14638Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14638Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cns.14638Direct OA link when available
- Concepts
-
Ataxia, Neuroscience, Cerebellar ataxia, Deep brain stimulation, Motor coordination, Computer science, Psychology, Medicine, Parkinson's disease, Internal medicine, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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74Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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