Abstract In the rapidly evolving landscape of healthcare and drug development, the ability to efficiently collect, process, and analyze large volumes of real‐world data (RWD) is critical for advancing drug development. This article provides a blueprint for establishing an end‐to‐end data and analytics pipeline in a cloud‐based environment. The pipeline presented here includes four major components, including data ingestion, transformation, visualization, and analytics, each supported by a suite of Amazon Web Servi…