Real‐World Outcomes of the Initial Clip Selection for Transcatheter Edge‐to‐Edge Repair Using the MitraClip G4 From the Optimized Catheter Valvular Intervention‐Mitral Registry Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.1161/jaha.125.041907
Background The association of outcomes with initial clip selection has not been investigated in patients undergoing transcatheter edge‐to‐edge repair with the MitraClip G4. Methods We analyzed 2257 patients receiving the MitraClip G4 according to the initial clip type: short (NT/NTW) versus long (XT/XTW) and narrow (NT/XT) versus wide (NTW/XTW). We performed a propensity‐matched analysis of baseline anatomical features in patients with primary and secondary mitral regurgitation (MR). Results The proportions of the initial clip types were as follows: NT, 18.9%; NTW, 41.7%; XT, 5.1%; and XTW, 34.3%. The proportions of the MR severity ≤1+ at discharge and 1 year were not significantly different among the 4 clip types. The incidence of death or heart failure hospitalization was not significantly different between the initial long and short clip groups and between the initial wide and narrow clip groups. After propensity matching, in patients with primary MR, long clips were significantly associated with a greater MR reduction (2.87±0.89 versus 2.62±0.99, P =0.04) and a higher proportion of the MR severity ≤1+ at 1 year (68.2% versus 48.6%, P =0.04) than short clips. In patients with secondary MR, long or wide clips had a similar MR severity at discharge and 1 year as short or narrow clips. Conclusions Residual MR severity and outcomes were not different regardless of the initial clip type, indicating the optimal clip selection in the real‐world settings with the MitraClip G4. In patients with primary MR, greater and more durable MR reduction may be expected by using the initial long clips. Registration URL: https://www.umin.ac.jp/ctr/ ; Unique identifier: UMIN‐ID: UMIN000023653.
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- article
- Language
- en
- Landing Page
- https://doi.org/10.1161/jaha.125.041907
- https://www.ahajournals.org/doi/pdf/10.1161/JAHA.125.041907
- OA Status
- gold
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413834571
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413834571Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1161/jaha.125.041907Digital Object Identifier
- Title
-
Real‐World Outcomes of the Initial Clip Selection for Transcatheter Edge‐to‐Edge Repair Using the MitraClip G4 From the Optimized Catheter Valvular Intervention‐Mitral RegistryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-08-29Full publication date if available
- Authors
-
Shunsuke Kubo, Masanori Yamamoto, Mike Saji, Masahiko Asami, Yusuke Enta, Shinichi Shirai, Masaki Izumo, Yusuke Watanabe, Yuki Izumi, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Daisuke Hachinohe, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiro Yamawaki, Hiroshi Ueno, Gaku Nakazawa, Toshiaki Otsuka, Kentaro Hayashida, Kentaro Hayashida, Makoto Tanaka, Hikaru Tsuruta, Tetsuya Saito, Yusuke Kobari, Toshinobu Ryuzaki, Tatsuo Takahashi, Shinichi Goto, Shohei Imaeda, Shingo Sakata, Yoshinori Katsumata, Kohsuke Shirakawa, Juri Iwata, Keitaro Shinada, Akiyoshi Kajino, Jungo Kato, Ryo Arita, T. Moriizumi, Masanori Yamamoto, Mitsuru Sago, Tatsuya Tsunaki, Ryo Yamaguchi, Junji Yanagisawa, Yuki Okubo, Ai Kagase, Takahiro Tokuda, Yuki Nakashima, Toshihiro Kobayashi, Ko Shibata, Ryoutaku Kawahata, Hiroto Nishio, Yuki Kondo, Tomofumi Nakamura, Hiroshi Tsunamoto, Tetsuro Shimura, Yutaka Koyama, Munenori Okubo, Shunsuke Imai, Tokuya Sakakura, Yoshihiro Harano, M. Inagaki, Hirooki Higami, Yoji Kuze, Takashi Nagai, Azusa Murata, Shinichi Shirai, Akihiro Isotani, Kenichi Ishizu, Masato Fukunaga, Hiroyuki Tabata, Toru Morofuji, Hiroyuki Kono, Maiko Kuroda, Euihong Ko, Norihisa Miyawaki, Kenji Nakano, Katsunori Miyahara, Ko Yamamoto, Koumei Onuki, Yasuo Tsuru, Tomohiro Suenaga, Akira Otani, Yusuke Watanabe, Taiga Katayama, Hirofumi Hioki, Jun‐ichi Nishikawa, Yosei Iseki, Yasuyuki Tsuchida, Kento Kito, Joe Omiya, Masataka Arakawa, Maki Okamoto, Masafumi Saito, Mizuki Miura, Toru Naganuma, Toru Ouchi, Haruhito Yuki, Masahiro Yamawaki, Yusuke EntaList of authors in order
- Landing page
-
https://doi.org/10.1161/jaha.125.041907Publisher landing page
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https://www.ahajournals.org/doi/pdf/10.1161/JAHA.125.041907Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
-
https://www.ahajournals.org/doi/pdf/10.1161/JAHA.125.041907Direct OA link when available
- Concepts
-
Medicine, MitraClip, Mitral regurgitation, CLIPS, Propensity score matching, Catheter, Cardiology, Mitral valve, Surgery, Internal medicine, Incidence (geometry), Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| title | Real‐World Outcomes of the Initial Clip Selection for Transcatheter Edge‐to‐Edge Repair Using the MitraClip G4 From the Optimized Catheter Valvular Intervention‐Mitral Registry |
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