Recent advancements and future requirements in vascularization of cortical organoids Article Swipe
Erin LaMontagne
,
Alysson R. Muotri
,
Adam J. Engler
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2022.1048731
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fbioe.2022.1048731
The fields of tissue engineering and disease modeling have become increasingly cognizant of the need to create complex and mature structures in vitro to adequately mimic the in vivo niche. Specifically for neural applications, human brain cortical organoids (COs) require highly stratified neurons and glial cells to generate synaptic functions, and to date, most efforts achieve only fetal functionality at best. Moreover, COs are usually avascular, inducing the development of necrotic cores, which can limit growth, development, and maturation. Recent efforts have attempted to vascularize cortical and other organoid types. In this review, we will outline the components of a fully vascularized CO as they relate to neocortical development in vivo . These components address challenges in recapitulating neurovascular tissue patterning, biomechanical properties, and functionality with the goal of mirroring the quality of organoid vascularization only achieved with an in vivo host. We will provide a comprehensive summary of the current progress made in each one of these categories, highlighting advances in vascularization technologies and areas still under investigation.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fbioe.2022.1048731
- https://www.frontiersin.org/articles/10.3389/fbioe.2022.1048731/pdf
- OA Status
- gold
- Cited By
- 23
- References
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4308419361Canonical identifier for this work in OpenAlex
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https://doi.org/10.3389/fbioe.2022.1048731Digital Object Identifier
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Recent advancements and future requirements in vascularization of cortical organoidsWork title
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-11-03Full publication date if available
- Authors
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Erin LaMontagne, Alysson R. Muotri, Adam J. EnglerList of authors in order
- Landing page
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https://doi.org/10.3389/fbioe.2022.1048731Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fbioe.2022.1048731/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fbioe.2022.1048731/pdfDirect OA link when available
- Concepts
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Organoid, Neuroscience, Neurovascular bundle, Biology, In vivo, Computer science, Anatomy, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
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23Total citation count in OpenAlex
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2025: 12, 2024: 6, 2023: 5Per-year citation counts (last 5 years)
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99Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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