Recent Advances in Nanotechnology-Based Strategies for Bone Tuberculosis Management Article Swipe
Yuanrui Luo
,
Hongwei Chen
,
Hua Chen
,
Peng Xiu
,
Jiancheng Zeng
,
Yueming Song
,
Tao Li
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ph17020170
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ph17020170
Bone tuberculosis, an extrapulmonary manifestation of tuberculosis, presents unique treatment challenges, including its insidious onset and complex pathology. While advancements in anti-tubercular therapy have been made, the efficacy is often limited by difficulties in achieving targeted drug concentrations and avoiding systemic toxicity. The intricate bone structure and presence of granulomas further impede effective drug delivery. Nano-drug delivery systems have emerged as a promising alternative, offering the enhanced targeting of anti-tubercular drugs. These systems, characterized by their minute size and adaptable surface properties, can be tailored to improve drug solubility, stability, and bioavailability, while also responding to specific stimuli within the bone TB microenvironment for controlled drug release. Nano-drug delivery systems can encapsulate drugs for precise delivery to the infection site. A significant innovation is their integration with prosthetics or biomaterials, which aids in both drug delivery and bone reconstruction, addressing the infection and its osteological consequences. This review provides a comprehensive overview of the pathophysiology of bone tuberculosis and its current treatments, emphasizing their limitations. It then delves into the advancements in nano-drug delivery systems, discussing their design, functionality, and role in bone TB therapy. The review assesses their potential in preclinical research, particularly in targeted drug delivery, treatment efficacy, and a reduction of side effects. Finally, it highlights the transformative promise of nanotechnology in bone TB treatments and suggests future research directions in this evolving field.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ph17020170
- https://www.mdpi.com/1424-8247/17/2/170/pdf?version=1706515898
- OA Status
- gold
- Cited By
- 7
- References
- 160
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391323648
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391323648Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ph17020170Digital Object Identifier
- Title
-
Recent Advances in Nanotechnology-Based Strategies for Bone Tuberculosis ManagementWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-29Full publication date if available
- Authors
-
Yuanrui Luo, Hongwei Chen, Hua Chen, Peng Xiu, Jiancheng Zeng, Yueming Song, Tao LiList of authors in order
- Landing page
-
https://doi.org/10.3390/ph17020170Publisher landing page
- PDF URL
-
https://www.mdpi.com/1424-8247/17/2/170/pdf?version=1706515898Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1424-8247/17/2/170/pdf?version=1706515898Direct OA link when available
- Concepts
-
Drug delivery, Medicine, Tuberculosis, Drug, Targeted drug delivery, Intensive care medicine, Pharmacology, Nanotechnology, Pathology, Materials scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
7Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
160Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4391323648 |
|---|---|
| doi | https://doi.org/10.3390/ph17020170 |
| ids.doi | https://doi.org/10.3390/ph17020170 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38399384 |
| ids.openalex | https://openalex.org/W4391323648 |
| fwci | 8.74044582 |
| type | article |
| title | Recent Advances in Nanotechnology-Based Strategies for Bone Tuberculosis Management |
| biblio.issue | 2 |
| biblio.volume | 17 |
| biblio.last_page | 170 |
| biblio.first_page | 170 |
| topics[0].id | https://openalex.org/T11381 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2746 |
| topics[0].subfield.display_name | Surgery |
| topics[0].display_name | Infectious Diseases and Tuberculosis |
| topics[1].id | https://openalex.org/T11293 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9994000196456909 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2746 |
| topics[1].subfield.display_name | Surgery |
| topics[1].display_name | Orthopedic Infections and Treatments |
| topics[2].id | https://openalex.org/T10038 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9836999773979187 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2725 |
| topics[2].subfield.display_name | Infectious Diseases |
| topics[2].display_name | Tuberculosis Research and Epidemiology |
| is_xpac | False |
| apc_list.value | 2000 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2165 |
| apc_paid.value | 2000 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2165 |
| concepts[0].id | https://openalex.org/C2779820397 |
| concepts[0].level | 2 |
| concepts[0].score | 0.7293667793273926 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1392806 |
| concepts[0].display_name | Drug delivery |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.698082685470581 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2781069245 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5806746482849121 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q12204 |
| concepts[2].display_name | Tuberculosis |
| concepts[3].id | https://openalex.org/C2780035454 |
| concepts[3].level | 2 |
| concepts[3].score | 0.4948412775993347 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q8386 |
| concepts[3].display_name | Drug |
| concepts[4].id | https://openalex.org/C126511603 |
| concepts[4].level | 3 |
| concepts[4].score | 0.47020870447158813 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q1261145 |
| concepts[4].display_name | Targeted drug delivery |
| concepts[5].id | https://openalex.org/C177713679 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3721557557582855 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q679690 |
| concepts[5].display_name | Intensive care medicine |
| concepts[6].id | https://openalex.org/C98274493 |
| concepts[6].level | 1 |
| concepts[6].score | 0.31841230392456055 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[6].display_name | Pharmacology |
| concepts[7].id | https://openalex.org/C171250308 |
| concepts[7].level | 1 |
| concepts[7].score | 0.3008865714073181 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q11468 |
| concepts[7].display_name | Nanotechnology |
| concepts[8].id | https://openalex.org/C142724271 |
| concepts[8].level | 1 |
| concepts[8].score | 0.17582863569259644 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[8].display_name | Pathology |
| concepts[9].id | https://openalex.org/C192562407 |
| concepts[9].level | 0 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[9].display_name | Materials science |
| keywords[0].id | https://openalex.org/keywords/drug-delivery |
| keywords[0].score | 0.7293667793273926 |
| keywords[0].display_name | Drug delivery |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.698082685470581 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/tuberculosis |
| keywords[2].score | 0.5806746482849121 |
| keywords[2].display_name | Tuberculosis |
| keywords[3].id | https://openalex.org/keywords/drug |
| keywords[3].score | 0.4948412775993347 |
| keywords[3].display_name | Drug |
| keywords[4].id | https://openalex.org/keywords/targeted-drug-delivery |
| keywords[4].score | 0.47020870447158813 |
| keywords[4].display_name | Targeted drug delivery |
| keywords[5].id | https://openalex.org/keywords/intensive-care-medicine |
| keywords[5].score | 0.3721557557582855 |
| keywords[5].display_name | Intensive care medicine |
| keywords[6].id | https://openalex.org/keywords/pharmacology |
| keywords[6].score | 0.31841230392456055 |
| keywords[6].display_name | Pharmacology |
| keywords[7].id | https://openalex.org/keywords/nanotechnology |
| keywords[7].score | 0.3008865714073181 |
| keywords[7].display_name | Nanotechnology |
| keywords[8].id | https://openalex.org/keywords/pathology |
| keywords[8].score | 0.17582863569259644 |
| keywords[8].display_name | Pathology |
| language | en |
| locations[0].id | doi:10.3390/ph17020170 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S16322639 |
| locations[0].source.issn | 1424-8247 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1424-8247 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Pharmaceuticals |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1424-8247/17/2/170/pdf?version=1706515898 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Pharmaceuticals |
| locations[0].landing_page_url | https://doi.org/10.3390/ph17020170 |
| locations[1].id | pmid:38399384 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Pharmaceuticals (Basel, Switzerland) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38399384 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10893314 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10893314/pdf/pharmaceuticals-17-00170.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Pharmaceuticals (Basel) |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10893314 |
| locations[3].id | pmh:oai:doaj.org/article:0752d374a11d429ea1c2c75267927b0f |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Pharmaceuticals, Vol 17, Iss 2, p 170 (2024) |
| locations[3].landing_page_url | https://doaj.org/article/0752d374a11d429ea1c2c75267927b0f |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5069974165 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7872-4365 |
| authorships[0].author.display_name | Yuanrui Luo |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[0].institutions[0].id | https://openalex.org/I24185976 |
| authorships[0].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Sichuan University |
| authorships[0].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[0].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yuanrui Luo |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[1].author.id | https://openalex.org/A5100324854 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4079-0153 |
| authorships[1].author.display_name | Hongwei Chen |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[1].institutions[0].id | https://openalex.org/I24185976 |
| authorships[1].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Sichuan University |
| authorships[1].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[1].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Hongwei Chen |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[2].author.id | https://openalex.org/A5100380218 |
| authorships[2].author.orcid | https://orcid.org/0009-0008-0893-0444 |
| authorships[2].author.display_name | Hua Chen |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[2].institutions[0].id | https://openalex.org/I24185976 |
| authorships[2].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Sichuan University |
| authorships[2].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[2].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Hua Chen |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[3].author.id | https://openalex.org/A5101658285 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-5688-5245 |
| authorships[3].author.display_name | Peng Xiu |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[3].institutions[0].id | https://openalex.org/I24185976 |
| authorships[3].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Sichuan University |
| authorships[3].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[3].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Peng Xiu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[4].author.id | https://openalex.org/A5063760627 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-6117-2856 |
| authorships[4].author.display_name | Jiancheng Zeng |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[4].institutions[0].id | https://openalex.org/I24185976 |
| authorships[4].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Sichuan University |
| authorships[4].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[4].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jiancheng Zeng |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[5].author.id | https://openalex.org/A5039921012 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-2377-0740 |
| authorships[5].author.display_name | Yueming Song |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[5].institutions[0].id | https://openalex.org/I24185976 |
| authorships[5].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Sichuan University |
| authorships[5].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[5].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yueming Song |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[6].author.id | https://openalex.org/A5100455340 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7988-3090 |
| authorships[6].author.display_name | Tao Li |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| authorships[6].institutions[0].id | https://openalex.org/I24185976 |
| authorships[6].institutions[0].ror | https://ror.org/011ashp19 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I24185976 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Sichuan University |
| authorships[6].institutions[1].id | https://openalex.org/I4210089761 |
| authorships[6].institutions[1].ror | https://ror.org/007mrxy13 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210089761 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | West China Hospital of Sichuan University |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Tao Li |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu 610041, China |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1424-8247/17/2/170/pdf?version=1706515898 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Recent Advances in Nanotechnology-Based Strategies for Bone Tuberculosis Management |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11381 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2746 |
| primary_topic.subfield.display_name | Surgery |
| primary_topic.display_name | Infectious Diseases and Tuberculosis |
| related_works | https://openalex.org/W3157244191, https://openalex.org/W4361283779, https://openalex.org/W1991750263, https://openalex.org/W2066459637, https://openalex.org/W2013980844, https://openalex.org/W3205983928, https://openalex.org/W2310386210, https://openalex.org/W4225149236, https://openalex.org/W2186824132, https://openalex.org/W2018282398 |
| cited_by_count | 7 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3390/ph17020170 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S16322639 |
| best_oa_location.source.issn | 1424-8247 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1424-8247 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Pharmaceuticals |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1424-8247/17/2/170/pdf?version=1706515898 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Pharmaceuticals |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ph17020170 |
| primary_location.id | doi:10.3390/ph17020170 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S16322639 |
| primary_location.source.issn | 1424-8247 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1424-8247 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Pharmaceuticals |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1424-8247/17/2/170/pdf?version=1706515898 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Pharmaceuticals |
| primary_location.landing_page_url | https://doi.org/10.3390/ph17020170 |
| publication_date | 2024-01-29 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2021731418, https://openalex.org/W2003537082, https://openalex.org/W3124115596, https://openalex.org/W3008767706, https://openalex.org/W3013727897, https://openalex.org/W3169859285, https://openalex.org/W4283642303, https://openalex.org/W2067405486, https://openalex.org/W4385719708, https://openalex.org/W4283066798, https://openalex.org/W3163607444, https://openalex.org/W4389313189, https://openalex.org/W2792711723, https://openalex.org/W3081800208, https://openalex.org/W3003324146, https://openalex.org/W2781763640, https://openalex.org/W4231972152, https://openalex.org/W3138262136, https://openalex.org/W2084306565, https://openalex.org/W2395952070, https://openalex.org/W4296794275, https://openalex.org/W1985341476, https://openalex.org/W3149919171, https://openalex.org/W4295297466, https://openalex.org/W4223610135, https://openalex.org/W3110665069, https://openalex.org/W3203969340, https://openalex.org/W4385765528, https://openalex.org/W2070172194, https://openalex.org/W2029152215, https://openalex.org/W2804115300, https://openalex.org/W4380082098, https://openalex.org/W2594925881, https://openalex.org/W4205395075, https://openalex.org/W2626528112, https://openalex.org/W6659420745, https://openalex.org/W4386263160, https://openalex.org/W4387341128, https://openalex.org/W2127571922, https://openalex.org/W4324377471, https://openalex.org/W4362561271, https://openalex.org/W2972675045, https://openalex.org/W4316468700, https://openalex.org/W2071578147, https://openalex.org/W2988995823, https://openalex.org/W2133199321, https://openalex.org/W4286560327, https://openalex.org/W1987637507, https://openalex.org/W4312138380, https://openalex.org/W4376226749, https://openalex.org/W3134614673, https://openalex.org/W2796886518, https://openalex.org/W3005315518, https://openalex.org/W2946008081, https://openalex.org/W4377104356, https://openalex.org/W2766934493, https://openalex.org/W2404758810, https://openalex.org/W3165577352, https://openalex.org/W2001811916, https://openalex.org/W2020976497, https://openalex.org/W2027951201, https://openalex.org/W2107340859, https://openalex.org/W3127731525, https://openalex.org/W2605603483, https://openalex.org/W2943128822, https://openalex.org/W2561878736, https://openalex.org/W2982377117, https://openalex.org/W2898331678, https://openalex.org/W2926159875, https://openalex.org/W3011718032, https://openalex.org/W2510576587, https://openalex.org/W4220680355, https://openalex.org/W4389224194, https://openalex.org/W2159887397, https://openalex.org/W2068468670, https://openalex.org/W2909816341, https://openalex.org/W2111469399, https://openalex.org/W3163111668, https://openalex.org/W4375954759, https://openalex.org/W1998718614, https://openalex.org/W3037459419, https://openalex.org/W2163753433, https://openalex.org/W4380087227, https://openalex.org/W2944831685, https://openalex.org/W2910869461, https://openalex.org/W3160309110, https://openalex.org/W1994919360, https://openalex.org/W4308545102, https://openalex.org/W4316038931, https://openalex.org/W2152479964, https://openalex.org/W2903281005, https://openalex.org/W4213076354, https://openalex.org/W3194836849, https://openalex.org/W2911499655, https://openalex.org/W3213438222, https://openalex.org/W4224233348, https://openalex.org/W3179227540, https://openalex.org/W2961627908, https://openalex.org/W2136510151, https://openalex.org/W4388961673, https://openalex.org/W1848769965, https://openalex.org/W4296462981, https://openalex.org/W2159065812, https://openalex.org/W2555913913, https://openalex.org/W3176970273, https://openalex.org/W4360807482, https://openalex.org/W4288462104, https://openalex.org/W3165522061, https://openalex.org/W4281775159, https://openalex.org/W2981110989, https://openalex.org/W3152106148, https://openalex.org/W2262375132, https://openalex.org/W4387076216, https://openalex.org/W4385483198, https://openalex.org/W3087733506, https://openalex.org/W2259756882, https://openalex.org/W4321497327, https://openalex.org/W2782405156, https://openalex.org/W4292554406, https://openalex.org/W6766396649, https://openalex.org/W2794863208, https://openalex.org/W2902137063, https://openalex.org/W4206691554, https://openalex.org/W2897401705, https://openalex.org/W4286560925, https://openalex.org/W4320038999, https://openalex.org/W4367050852, https://openalex.org/W3205834792, https://openalex.org/W2980509397, https://openalex.org/W3024477266, https://openalex.org/W4388572055, https://openalex.org/W4313891695, https://openalex.org/W4220775905, https://openalex.org/W2021303978, https://openalex.org/W2066044675, https://openalex.org/W3196814055, https://openalex.org/W4285591129, https://openalex.org/W1964156573, https://openalex.org/W6711819532, https://openalex.org/W6810485851, https://openalex.org/W2308019032, https://openalex.org/W2576321768, https://openalex.org/W2621906742, https://openalex.org/W3080764393, https://openalex.org/W3161849541, https://openalex.org/W2520763435, https://openalex.org/W3017928579, https://openalex.org/W1969930465, https://openalex.org/W2151849897, https://openalex.org/W2127966748, https://openalex.org/W2946154710, https://openalex.org/W3012966186, https://openalex.org/W3216337345, https://openalex.org/W3087092972, https://openalex.org/W2108992042, https://openalex.org/W4380881839, https://openalex.org/W2035363922, https://openalex.org/W4226469175, https://openalex.org/W4221127413, https://openalex.org/W2963439065 |
| referenced_works_count | 160 |
| abstract_inverted_index.A | 120 |
| abstract_inverted_index.a | 61, 149, 201 |
| abstract_inverted_index.It | 165 |
| abstract_inverted_index.TB | 101, 183, 216 |
| abstract_inverted_index.an | 2 |
| abstract_inverted_index.as | 60 |
| abstract_inverted_index.be | 83 |
| abstract_inverted_index.by | 31, 74 |
| abstract_inverted_index.in | 20, 33, 132, 171, 181, 190, 194, 214, 223 |
| abstract_inverted_index.is | 28, 123 |
| abstract_inverted_index.it | 207 |
| abstract_inverted_index.of | 5, 48, 68, 152, 155, 203, 212 |
| abstract_inverted_index.or | 128 |
| abstract_inverted_index.to | 85, 95, 116 |
| abstract_inverted_index.The | 42, 185 |
| abstract_inverted_index.and | 15, 38, 46, 78, 90, 136, 142, 158, 179, 200, 218 |
| abstract_inverted_index.can | 82, 110 |
| abstract_inverted_index.for | 103, 113 |
| abstract_inverted_index.its | 12, 143, 159 |
| abstract_inverted_index.the | 26, 65, 99, 117, 140, 153, 169, 209 |
| abstract_inverted_index.Bone | 0 |
| abstract_inverted_index.This | 146 |
| abstract_inverted_index.aids | 131 |
| abstract_inverted_index.also | 93 |
| abstract_inverted_index.been | 24 |
| abstract_inverted_index.bone | 44, 100, 137, 156, 182, 215 |
| abstract_inverted_index.both | 133 |
| abstract_inverted_index.drug | 36, 53, 87, 105, 134, 196 |
| abstract_inverted_index.have | 23, 58 |
| abstract_inverted_index.into | 168 |
| abstract_inverted_index.role | 180 |
| abstract_inverted_index.side | 204 |
| abstract_inverted_index.size | 77 |
| abstract_inverted_index.then | 166 |
| abstract_inverted_index.this | 224 |
| abstract_inverted_index.with | 126 |
| abstract_inverted_index.These | 71 |
| abstract_inverted_index.While | 18 |
| abstract_inverted_index.drugs | 112 |
| abstract_inverted_index.made, | 25 |
| abstract_inverted_index.often | 29 |
| abstract_inverted_index.onset | 14 |
| abstract_inverted_index.site. | 119 |
| abstract_inverted_index.their | 75, 124, 163, 176, 188 |
| abstract_inverted_index.which | 130 |
| abstract_inverted_index.while | 92 |
| abstract_inverted_index.delves | 167 |
| abstract_inverted_index.drugs. | 70 |
| abstract_inverted_index.field. | 226 |
| abstract_inverted_index.future | 220 |
| abstract_inverted_index.impede | 51 |
| abstract_inverted_index.minute | 76 |
| abstract_inverted_index.review | 147, 186 |
| abstract_inverted_index.unique | 8 |
| abstract_inverted_index.within | 98 |
| abstract_inverted_index.complex | 16 |
| abstract_inverted_index.current | 160 |
| abstract_inverted_index.design, | 177 |
| abstract_inverted_index.emerged | 59 |
| abstract_inverted_index.further | 50 |
| abstract_inverted_index.improve | 86 |
| abstract_inverted_index.limited | 30 |
| abstract_inverted_index.precise | 114 |
| abstract_inverted_index.promise | 211 |
| abstract_inverted_index.stimuli | 97 |
| abstract_inverted_index.surface | 80 |
| abstract_inverted_index.systems | 57, 109 |
| abstract_inverted_index.therapy | 22 |
| abstract_inverted_index.Finally, | 206 |
| abstract_inverted_index.assesses | 187 |
| abstract_inverted_index.avoiding | 39 |
| abstract_inverted_index.delivery | 56, 108, 115, 135, 173 |
| abstract_inverted_index.effects. | 205 |
| abstract_inverted_index.efficacy | 27 |
| abstract_inverted_index.enhanced | 66 |
| abstract_inverted_index.evolving | 225 |
| abstract_inverted_index.offering | 64 |
| abstract_inverted_index.overview | 151 |
| abstract_inverted_index.presence | 47 |
| abstract_inverted_index.presents | 7 |
| abstract_inverted_index.provides | 148 |
| abstract_inverted_index.release. | 106 |
| abstract_inverted_index.research | 221 |
| abstract_inverted_index.specific | 96 |
| abstract_inverted_index.suggests | 219 |
| abstract_inverted_index.systemic | 40 |
| abstract_inverted_index.systems, | 72, 174 |
| abstract_inverted_index.tailored | 84 |
| abstract_inverted_index.targeted | 35, 195 |
| abstract_inverted_index.therapy. | 184 |
| abstract_inverted_index.Nano-drug | 55, 107 |
| abstract_inverted_index.achieving | 34 |
| abstract_inverted_index.adaptable | 79 |
| abstract_inverted_index.delivery, | 197 |
| abstract_inverted_index.delivery. | 54 |
| abstract_inverted_index.effective | 52 |
| abstract_inverted_index.efficacy, | 199 |
| abstract_inverted_index.including | 11 |
| abstract_inverted_index.infection | 118, 141 |
| abstract_inverted_index.insidious | 13 |
| abstract_inverted_index.intricate | 43 |
| abstract_inverted_index.nano-drug | 172 |
| abstract_inverted_index.potential | 189 |
| abstract_inverted_index.promising | 62 |
| abstract_inverted_index.reduction | 202 |
| abstract_inverted_index.research, | 192 |
| abstract_inverted_index.structure | 45 |
| abstract_inverted_index.targeting | 67 |
| abstract_inverted_index.toxicity. | 41 |
| abstract_inverted_index.treatment | 9, 198 |
| abstract_inverted_index.addressing | 139 |
| abstract_inverted_index.controlled | 104 |
| abstract_inverted_index.directions | 222 |
| abstract_inverted_index.discussing | 175 |
| abstract_inverted_index.granulomas | 49 |
| abstract_inverted_index.highlights | 208 |
| abstract_inverted_index.innovation | 122 |
| abstract_inverted_index.pathology. | 17 |
| abstract_inverted_index.responding | 94 |
| abstract_inverted_index.stability, | 89 |
| abstract_inverted_index.treatments | 217 |
| abstract_inverted_index.challenges, | 10 |
| abstract_inverted_index.emphasizing | 162 |
| abstract_inverted_index.encapsulate | 111 |
| abstract_inverted_index.integration | 125 |
| abstract_inverted_index.preclinical | 191 |
| abstract_inverted_index.properties, | 81 |
| abstract_inverted_index.prosthetics | 127 |
| abstract_inverted_index.significant | 121 |
| abstract_inverted_index.solubility, | 88 |
| abstract_inverted_index.treatments, | 161 |
| abstract_inverted_index.advancements | 19, 170 |
| abstract_inverted_index.alternative, | 63 |
| abstract_inverted_index.difficulties | 32 |
| abstract_inverted_index.limitations. | 164 |
| abstract_inverted_index.osteological | 144 |
| abstract_inverted_index.particularly | 193 |
| abstract_inverted_index.tuberculosis | 157 |
| abstract_inverted_index.biomaterials, | 129 |
| abstract_inverted_index.characterized | 73 |
| abstract_inverted_index.comprehensive | 150 |
| abstract_inverted_index.consequences. | 145 |
| abstract_inverted_index.manifestation | 4 |
| abstract_inverted_index.tuberculosis, | 1, 6 |
| abstract_inverted_index.concentrations | 37 |
| abstract_inverted_index.extrapulmonary | 3 |
| abstract_inverted_index.functionality, | 178 |
| abstract_inverted_index.nanotechnology | 213 |
| abstract_inverted_index.transformative | 210 |
| abstract_inverted_index.anti-tubercular | 21, 69 |
| abstract_inverted_index.pathophysiology | 154 |
| abstract_inverted_index.reconstruction, | 138 |
| abstract_inverted_index.bioavailability, | 91 |
| abstract_inverted_index.microenvironment | 102 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5100455340 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 7 |
| corresponding_institution_ids | https://openalex.org/I24185976, https://openalex.org/I4210089761 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4699999988079071 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9550927 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |