Recent Advances in the Molecular Biology of Chronic Lymphocytic Leukemia: How to Define Prognosis and Guide Treatment Article Swipe
Annalisa Arcari
,
Lucia Morello
,
Elena Borotti
,
E Ronda
,
Rossi Angela
,
Daniele Vallisa
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cancers16203483
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cancers16203483
Chronic Lymphocytic Leukemia (CLL) is the most frequent type of leukemia in Western countries. In recent years, there have been important advances in the knowledge of molecular alterations that underlie the disease’s pathogenesis. Very heterogeneous prognostic subgroups have been identified by the mutational status of immunoglobulin heavy variable genes (IGVH), FISH analysis and molecular evaluation of TP53 mutations. Next-generation sequencing (NGS) technologies have provided a deeper characterization of the genomic and epigenomic landscape of CLL. New therapeutic targets have led to a progressive reduction of traditional chemoimmunotherapy in favor of specific biological agents. Furthermore, in the latest clinical trials, the minimal residual disease (MRD) has emerged as a potent marker of outcome and a guide to treatment duration. This review focuses on recent insights into the understanding of CLL biology. We also consider the translation of these findings into the development of risk-adapted and targeted therapeutic approaches.
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Metadata
- Type
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- Language
- en
- Landing Page
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All OpenAlex metadata
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https://openalex.org/W4403391753Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cancers16203483Digital Object Identifier
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Recent Advances in the Molecular Biology of Chronic Lymphocytic Leukemia: How to Define Prognosis and Guide TreatmentWork title
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reviewOpenAlex work type
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enPrimary language
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2024Year of publication
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2024-10-14Full publication date if available
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Annalisa Arcari, Lucia Morello, Elena Borotti, E Ronda, Rossi Angela, Daniele VallisaList of authors in order
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https://doi.org/10.3390/cancers16203483Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/cancers16203483Direct OA link when available
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Chronic lymphocytic leukemia, Computational biology, Medicine, Leukemia, Biology, ImmunologyTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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