Recent Advances in the Oxone-Mediated Synthesis of Heterocyclic Compounds Article Swipe

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Chemistry Chalcogen Environmentally friendly Combinatorial chemistry Organic synthesis Nanotechnology Organic chemistry Catalysis Materials science Biology Ecology

Helen A. Goulart , Daniela R. Araujo , Filipe Penteado , Raquel G. Jacob , Gelson Perin , Eder J. Lenardão ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.3390/molecules26247523 · OA: W4200251014

Oxone is a commercially available oxidant, composed of a mixture of three inorganic species, being the potassium peroxymonosulfate (KHSO5) the reactive one. Over the past few decades, this cheap and environmentally friendly oxidant has become a powerful tool in organic synthesis, being extensively employed to mediate the construction of a plethora of important compounds. This review summarizes the recent advances in the Oxone-mediated synthesis of N-, O- and chalcogen-containing heterocyclic compounds, through a wide diversity of reactions, starting from several kinds of substrate, highlighting the main synthetic differences, advantages, the scope and limitations.