Recent Progress in Synthetic and Natural Catechol-O-methyltransferase Inhibitors for Neurological Disorders Article Swipe
Sandeep Bindra
,
Ananya Datta
,
Haya Yasin
,
Riya Rachel Thomas
,
Shailesh Verma
,
Ankita Patel
,
Della Grace Thomas Parambi
,
Suraj N. Mali
,
T. M. Rangarajan
,
Bijo Mathew
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.4c06190
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acsomega.4c06190
Catechol-O-methyltransferase (COMT) inhibitors have played a crucial role in the development of potent and selective drugs for the treatment of Parkinson's disease, depression, and anxiety disorders. This review provides a comprehensive analysis of the structure-activity relationship (SAR) of COMT inhibitors, highlighting key structural features and pharmacophoric elements that govern their potency, selectivity, and pharmacokinetic properties. This review also discusses the application of SAR principles in the design and optimization of COMT inhibitors. Our analysis reveals the emergence of novel chemical scaffolds and the potential for COMT inhibitors to address unmet medical needs in neurology and psychiatry. This Perspective serves as a valuable resource for clinicians and researchers, providing insights into the rational design of COMT inhibitors and the development of next-generation therapeutics.
Related Topics
Concepts
Catechol
Natural (archaeology)
Catechol-O-methyl transferase
Methyltransferase
Chemistry
Neuroscience
Medicine
Pharmacology
Biochemistry
Psychology
Biology
Methylation
Allele
Paleontology
Gene
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsomega.4c06190
- OA Status
- gold
- Cited By
- 2
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403692878
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403692878Canonical identifier for this work in OpenAlex
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https://doi.org/10.1021/acsomega.4c06190Digital Object Identifier
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Recent Progress in Synthetic and Natural Catechol-O-methyltransferase Inhibitors for Neurological DisordersWork title
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reviewOpenAlex work type
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-10-23Full publication date if available
- Authors
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Sandeep Bindra, Ananya Datta, Haya Yasin, Riya Rachel Thomas, Shailesh Verma, Ankita Patel, Della Grace Thomas Parambi, Suraj N. Mali, T. M. Rangarajan, Bijo MathewList of authors in order
- Landing page
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https://doi.org/10.1021/acsomega.4c06190Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1021/acsomega.4c06190Direct OA link when available
- Concepts
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Catechol, Natural (archaeology), Catechol-O-methyl transferase, Methyltransferase, Chemistry, Neuroscience, Medicine, Pharmacology, Biochemistry, Psychology, Biology, Methylation, Allele, Paleontology, GeneTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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