Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virus Article Swipe
Chengfei Ge
,
Hangqiong Lu
,
Jinze Han
,
Guorong Sun
,
Shihao Li
,
Xingge Lan
,
Yongzhen Liu
,
Mengmeng Yu
,
Xinyun Hu
,
Mingxue Hu
,
Xiaole Qi
,
Hongyu Cui
,
Yulu Duan
,
Suyan Wang
,
Yuntong Chen
,
Xiaomei Wang
,
Yanping Zhang
,
Yulong Gao
,
Changjun Liu
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2024.1515415
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2024.1515415
Chicken infectious anemia (CIA) is a highly contagious disease caused by the chicken infectious anemia virus (CIAV), and it poses a serious threat to the poultry industry. However, effective control measures and strategies have not been identified. In this study, a recombinant Marek’s disease virus (rMDV) expressing the VP1 and VP2 proteins of CIAV was successfully constructed using CRISPR/Cas9, and a commercial Marek’s disease virus (MDV) vaccine strain was used as the vector. VP1 and VP2 expression by rMDV was confirmed by immunofluorescence assay and western blot analysis, which revealed robust in vitro expression. Further analysis showed that the VP1 and VP2 genes integrated into the MDV genome did not alter the growth kinetics of the virus and remained stable even after 20 passages, indicating the genetic stability of the recombinant virus. In animal studies, vaccination of one-day-old specific-pathogen-free chickens with rMDV induced high levels of CIAV-specific antibodies (1 × 10 5 ) and neutralizing antibodies (1:2 5 ) and a potent cellular immune response. Moreover, rMDV vaccination conferred an 85% protective index against challenge with a highly virulent strain of CIAV, significantly reducing the occurrence of anemia and thymic atrophy caused by CIAV infection and dramatically suppressing CIAV replication in the thymus. Collectively, these results highlight the potential of rMDV as a vaccine candidate for preventing and controlling CIAV infection, thus offering a new avenue for mitigating the impact of CIA on the poultry industry.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2024.1515415
- OA Status
- gold
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406083070
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4406083070Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2024.1515415Digital Object Identifier
- Title
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Recombinant Marek’s disease virus expressing VP1 and VP2 proteins provides robust immune protection against chicken infectious anemia virusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-01-06Full publication date if available
- Authors
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Chengfei Ge, Hangqiong Lu, Jinze Han, Guorong Sun, Shihao Li, Xingge Lan, Yongzhen Liu, Mengmeng Yu, Xinyun Hu, Mingxue Hu, Xiaole Qi, Hongyu Cui, Yulu Duan, Suyan Wang, Yuntong Chen, Xiaomei Wang, Yanping Zhang, Yulong Gao, Changjun LiuList of authors in order
- Landing page
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https://doi.org/10.3389/fmicb.2024.1515415Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fmicb.2024.1515415Direct OA link when available
- Concepts
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Virology, Virus, Immune system, Biology, Recombinant DNA, Marek's disease, Antibody, Infectious disease (medical specialty), Anemia, Disease, Immunology, Medicine, Gene, Genetics, Internal medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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