Recombinant Methioninase Selectively Eliminates Cancer Cells Co-cultured With Normal Fibroblasts Indicating the High-Precision Efficacy of Targeting Methionine Addiction of Cancer Article Swipe
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Byung Mo Kang
,
Qinghong Han
,
SHUKUAN LI
,
Jin-Soo Kim
,
KOHEI MIZUTA
,
Yohei Asano
,
YUTA MIYASHI
,
Michael Bouvet
,
Robert M. Hoffman
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21873/anticanres.17771
· OA: W4414542626
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21873/anticanres.17771
· OA: W4414542626
The differential sensitivity of cancer and normal cells to rMETase at 0.46 U/ml was so extensive that cancer cells were essentially eliminated from the co-cultures while the normal cells remained viable and proliferating. The difference in sensitivity of normal and cancer cells growing together suggests that rMETase selectively and precisely targets methionine addiction of cancer and can be a safe and effective clinical anti-cancer agent.
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