REcovery from DEXmedetomidine-Induced Unresponsiveness (REDEX): A Study Protocol for a Single Center, Parallel Arm, Non-Randomized, Controlled Pilot Trial in Healthy Volunteers Article Swipe
David R. Schreier
,
Matteo Fecchio
,
Christian S. Guay
,
Reid Kovacs
,
Mark Olchanyi
,
Ariel Mueller
,
Timothy T. Houle
,
Brian L. Edlow
,
Emery N. Brown
,
Ken Solt
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2147/nss.s523111
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2147/nss.s523111
This pilot trial will report on the effect of repeated DEX exposure on the recovery period, and the investigation of state transitions will advance our scientific understanding of altered states of consciousness. REDEX will provide valuable insights and data for designing future DEX sedation studies. Moreover, we will report on the potential of biological sex as a confounding factor and the feasibility of TMS-EEG under DEX.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2147/nss.s523111
- https://www.dovepress.com/article/download/103834
- OA Status
- gold
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411204081
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411204081Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2147/nss.s523111Digital Object Identifier
- Title
-
REcovery from DEXmedetomidine-Induced Unresponsiveness (REDEX): A Study Protocol for a Single Center, Parallel Arm, Non-Randomized, Controlled Pilot Trial in Healthy VolunteersWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-06-01Full publication date if available
- Authors
-
David R. Schreier, Matteo Fecchio, Christian S. Guay, Reid Kovacs, Mark Olchanyi, Ariel Mueller, Timothy T. Houle, Brian L. Edlow, Emery N. Brown, Ken SoltList of authors in order
- Landing page
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https://doi.org/10.2147/nss.s523111Publisher landing page
- PDF URL
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https://www.dovepress.com/article/download/103834Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.dovepress.com/article/download/103834Direct OA link when available
- Concepts
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Medicine, Dexmedetomidine, Protocol (science), Randomized controlled trial, Single Center, Pilot trial, Anesthesia, Surgery, Alternative medicine, Pathology, SedationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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40Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.DEX. | 65 |
| abstract_inverted_index.This | 0 |
| abstract_inverted_index.data | 38 |
| abstract_inverted_index.will | 3, 22, 33, 47 |
| abstract_inverted_index.REDEX | 32 |
| abstract_inverted_index.pilot | 1 |
| abstract_inverted_index.state | 20 |
| abstract_inverted_index.trial | 2 |
| abstract_inverted_index.under | 64 |
| abstract_inverted_index.effect | 7 |
| abstract_inverted_index.factor | 58 |
| abstract_inverted_index.future | 41 |
| abstract_inverted_index.report | 4, 48 |
| abstract_inverted_index.states | 29 |
| abstract_inverted_index.TMS-EEG | 63 |
| abstract_inverted_index.advance | 23 |
| abstract_inverted_index.altered | 28 |
| abstract_inverted_index.period, | 15 |
| abstract_inverted_index.provide | 34 |
| abstract_inverted_index.exposure | 11 |
| abstract_inverted_index.insights | 36 |
| abstract_inverted_index.recovery | 14 |
| abstract_inverted_index.repeated | 9 |
| abstract_inverted_index.sedation | 43 |
| abstract_inverted_index.studies. | 44 |
| abstract_inverted_index.valuable | 35 |
| abstract_inverted_index.Moreover, | 45 |
| abstract_inverted_index.designing | 40 |
| abstract_inverted_index.potential | 51 |
| abstract_inverted_index.biological | 53 |
| abstract_inverted_index.scientific | 25 |
| abstract_inverted_index.confounding | 57 |
| abstract_inverted_index.feasibility | 61 |
| abstract_inverted_index.transitions | 21 |
| abstract_inverted_index.investigation | 18 |
| abstract_inverted_index.understanding | 26 |
| abstract_inverted_index.consciousness. | 31 |
| cited_by_percentile_year | |
| countries_distinct_count | 2 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.5400000214576721 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.35232155 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |