Recurrent acromegaly: a systematic review on therapeutic approaches Article Swipe
Seyed Farzad Maroufi
,
Mohammadmahdi Sabahi
,
Seyed Sahab Aarabi
,
Mohammad Samadian
,
Rocco Dabecco
,
Badih Adada
,
Karla M. Arce
,
Hamid Borghei-Razavi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s12902-023-01533-w
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s12902-023-01533-w
Background and objective Management of recurrent acromegaly is challenging for both neurosurgeons and endocrinologists. Several treatment options including repeat surgery, medical therapy, and radiation are offered for such patients. The efficacy of these modalities for the treatment of recurrence has not been studied previously in the literature. In this study, we aim to systematically review the existing cases of recurrence and come to a conclusion regarding the appropriate treatment in such cases. Method A systematic review was performed through PubMed, Scopus, Web of Science, and Cochrane database to identify studies reporting the treatment outcome of recurrent acromegaly patients. Using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, the included studies were reviewed for primary and secondary treatment, complications, and outcomes of the secondary treatment. Results The systematic review retrieved 23 records with 95 cases of recurrent acromegaly. The mean time of recurrence was 4.16 years after the initial treatment. The most common primary treatment was surgery followed by radiotherapy. The remission rate was significantly higher in medical and radiotherapy compared to surgical treatment. Conclusion In cases of recurrent acromegaly, the patient may benefit more from radiotherapy and medical therapy compared to surgery. As the quality of evidence is low on this matter feature studies specifically designed for recurrent patients are needed.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12902-023-01533-w
- https://bmcendocrdisord.biomedcentral.com/counter/pdf/10.1186/s12902-023-01533-w
- OA Status
- gold
- Cited By
- 10
- References
- 67
- Related Works
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- OpenAlex ID
- https://openalex.org/W4391257882
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391257882Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12902-023-01533-wDigital Object Identifier
- Title
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Recurrent acromegaly: a systematic review on therapeutic approachesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-01-26Full publication date if available
- Authors
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Seyed Farzad Maroufi, Mohammadmahdi Sabahi, Seyed Sahab Aarabi, Mohammad Samadian, Rocco Dabecco, Badih Adada, Karla M. Arce, Hamid Borghei-RazaviList of authors in order
- Landing page
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https://doi.org/10.1186/s12902-023-01533-wPublisher landing page
- PDF URL
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https://bmcendocrdisord.biomedcentral.com/counter/pdf/10.1186/s12902-023-01533-wDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://bmcendocrdisord.biomedcentral.com/counter/pdf/10.1186/s12902-023-01533-wDirect OA link when available
- Concepts
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Medicine, Acromegaly, Radiation therapy, Systematic review, MEDLINE, Medical literature, Modalities, Pegvisomant, Surgery, Pediatrics, Internal medicine, Pathology, Growth hormone, Hormone, Law, Social science, Political science, SociologyTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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67Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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