Red Blood Cell Partitioning Using a Microfluidic Channel with Ladder Structure Article Swipe
Toru HYAKUTAKE
,
Yuya Tsutsumi
,
Yohei Miyoshi
,
Manabu Yasui
,
Tomoki Mizuno
,
Mizuki Tateno
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/mi14071421
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/mi14071421
This study investigated the partitioning characteristics of red blood cells (RBCs) within capillaries, with a specific focus on ladder structures observed near the end of the capillaries. In vitro experiments were conducted using microfluidic channels with a ladder structure model comprising six bifurcating channels that exhibited an anti-parallel flow configuration. The effects of various factors, such as the parent channel width, distance between branches, and hematocrit, on RBC partitioning in bifurcating channels were evaluated. A decrease in the parent channel width resulted in an increase in the heterogeneity in the hematocrit distribution and a bias in the fractional RBC flux. Additionally, variations in the distance between branches affected the RBC distribution, with smaller distances resulting in greater heterogeneity. The bias of the RBC distribution in the microchannel cross section had a major effect on the RBC partitioning characteristics. The influence of hematocrit variations on the RBC distribution was also investigated, with lower hematocrit values leading to a more pronounced bias in the RBC distribution. Overall, this study provides valuable insights into RBC distribution characteristics in capillary networks, contributing to our understanding of the physiological mechanisms of RBC phase separation in the microcirculatory system. These findings have implications for predicting oxygen heterogeneity in tissues and could aid in the study of diseases associated with impaired microcirculation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/mi14071421
- https://www.mdpi.com/2072-666X/14/7/1421/pdf?version=1689581587
- OA Status
- gold
- Cited By
- 1
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384557418
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4384557418Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/mi14071421Digital Object Identifier
- Title
-
Red Blood Cell Partitioning Using a Microfluidic Channel with Ladder StructureWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-14Full publication date if available
- Authors
-
Toru HYAKUTAKE, Yuya Tsutsumi, Yohei Miyoshi, Manabu Yasui, Tomoki Mizuno, Mizuki TatenoList of authors in order
- Landing page
-
https://doi.org/10.3390/mi14071421Publisher landing page
- PDF URL
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https://www.mdpi.com/2072-666X/14/7/1421/pdf?version=1689581587Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2072-666X/14/7/1421/pdf?version=1689581587Direct OA link when available
- Concepts
-
Hematocrit, Microchannel, Microcirculation, Red blood cell distribution width, Microfluidics, Red blood cell, Chemistry, Biophysics, Distribution (mathematics), Blood cell, Blood flow, Materials science, Nanotechnology, Internal medicine, Mathematics, Biology, Immunology, Biochemistry, Medicine, Mathematical analysisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
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35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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