Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by Upconversion Article Swipe
Ivana Miletto
,
Chiara Gionco
,
Maria Cristina Paganini
,
Erik Cerrato
,
Leonardo Marchese
,
Enrica Gianotti
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms23136951
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/ijms23136951
Upconversion (UC) nanoparticles characterized by red upconversion emission, particularly interesting for biological applications, have been prepared and subsequently modified by the covalent anchoring of Verteporfin (Ver), an FDA approved photosensitizer (PS) which usually exerts its photodynamic activity upon excitation with red light. ZrO2 was chosen as the platform where Yb3+ and Er3+ were inserted as the sensitizer and activator ions, respectively. Careful control of the doping ratio, along with a detailed physico-chemical characterization, was carried out. Upon functionalization with a silica shell to covalently anchor the photosensitizer, a theranostic nanoparticle was obtained whose architecture, thanks to a favorable energy level match and a uniform distribution of the PS, allowed us to trigger the photodynamic activity of Ver by upconversion, thus paving the way to the use of Photodynamic Therapy (PDT) in deep tissues, thanks to the higher penetrating power of NIR light.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms23136951
- https://www.mdpi.com/1422-0067/23/13/6951/pdf?version=1655985651
- OA Status
- gold
- Cited By
- 4
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4283314237
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https://openalex.org/W4283314237Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms23136951Digital Object Identifier
- Title
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Red Upconverter Nanocrystals Functionalized with Verteporfin for Photodynamic Therapy Triggered by UpconversionWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-06-22Full publication date if available
- Authors
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Ivana Miletto, Chiara Gionco, Maria Cristina Paganini, Erik Cerrato, Leonardo Marchese, Enrica GianottiList of authors in order
- Landing page
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https://doi.org/10.3390/ijms23136951Publisher landing page
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https://www.mdpi.com/1422-0067/23/13/6951/pdf?version=1655985651Direct link to full text PDF
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/23/13/6951/pdf?version=1655985651Direct OA link when available
- Concepts
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Verteporfin, Photon upconversion, Photodynamic therapy, Nanocrystal, Nanotechnology, Materials science, Medicine, Optoelectronics, Chemistry, Luminescence, Macular degeneration, Ophthalmology, Organic chemistry, Choroidal neovascularizationTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 2Per-year citation counts (last 5 years)
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64Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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