Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation Article Swipe
Gavin Pharaoh
,
Jacob L. Brown
,
Rojina Ranjit
,
Zoltán Ungvári
,
Holly Van Remmen
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/rco2.29
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/rco2.29
Background Mitochondrial bioenergetics are sensitive to adenosine diphosphate (ADP) concentration. Reactive oxygen species (ROS) production and respiration [oxygen consumption rate (OCR)] are altered at physiological ADP concentrations (i.e. ADP insensitivity) in aged human muscle. Here, we investigate ADP sensitivity in mouse muscle mitochondria. Methods We measured OCR and ROS production in permeabilized gastrocnemius fibres using an ADP titration protocol and the Oroboros O2k respirometer and fluorometer. We measured changes in ADP sensitivity in muscle from mice at different ages, after sciatic nerve transection (denervation), and in response to increased oxidative stress ( Sod1 −/− mice). Further, we asked whether the mitochondrial‐targeted peptide SS‐31 can modulate ADP insensitivity and contractile function in the Sod1 −/− mouse model. Results Reduced ADP sensitivity is associated with increases in mitochondrial ROS production in aged (62%) and Sod1 −/− (33%) mice. The maximal capacity to produce ROS does not increase with age, and there is no effect of age on ADP sensitivity for OCR in mouse gastrocnemii. Denervation does not induce ADP insensitivity for either ROS generation or OCR. Treatment of Sod1 −/− mice with SS‐31 increases ADP sensitivity for both OCR and ROS, decreases maximal ROS production (~40%), and improves resistance to muscle fatigue. Conclusions Adenosine diphosphate sensitivity for ROS production decreases in aged mouse gastrocnemius muscle fibres, although aged mice do not exhibit a difference in OCR. Denervation does not induce ADP insensitivity; however, insensitivity to ADP is induced in a model of oxidative stress. ADP insensitivity could contribute to muscle fatigue, and SS‐31 may be the first drug capable of targeting this aging phenotype.
Related Topics
Concepts
Adenosine diphosphate
Reactive oxygen species
Internal medicine
Mitochondrial ROS
Oxidative stress
Mitochondrion
Endocrinology
Skeletal muscle
Denervation
Adenosine triphosphate
Chemistry
Oxidative phosphorylation
Glycolysis
Adenosine
Bioenergetics
Biology
Biochemistry
Metabolism
Medicine
Platelet
Platelet aggregation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/rco2.29
- OA Status
- gold
- Cited By
- 22
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3118156944
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3118156944Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/rco2.29Digital Object Identifier
- Title
-
Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-28Full publication date if available
- Authors
-
Gavin Pharaoh, Jacob L. Brown, Rojina Ranjit, Zoltán Ungvári, Holly Van RemmenList of authors in order
- Landing page
-
https://doi.org/10.1002/rco2.29Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1002/rco2.29Direct OA link when available
- Concepts
-
Adenosine diphosphate, Reactive oxygen species, Internal medicine, Mitochondrial ROS, Oxidative stress, Mitochondrion, Endocrinology, Skeletal muscle, Denervation, Adenosine triphosphate, Chemistry, Oxidative phosphorylation, Glycolysis, Adenosine, Bioenergetics, Biology, Biochemistry, Metabolism, Medicine, Platelet, Platelet aggregationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 9, 2023: 7, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3118156944 |
|---|---|
| doi | https://doi.org/10.1002/rco2.29 |
| ids.doi | https://doi.org/10.1002/rco2.29 |
| ids.mag | 3118156944 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/36159599 |
| ids.openalex | https://openalex.org/W3118156944 |
| fwci | 0.78021579 |
| type | article |
| title | Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation |
| awards[0].id | https://openalex.org/G8708830162 |
| awards[0].funder_id | https://openalex.org/F4320337337 |
| awards[0].display_name | |
| awards[0].funder_award_id | P01AG051442 |
| awards[0].funder_display_name | National Institute on Aging |
| awards[1].id | https://openalex.org/G8502822227 |
| awards[1].funder_id | https://openalex.org/F4320337337 |
| awards[1].display_name | |
| awards[1].funder_award_id | T32AG052363 |
| awards[1].funder_display_name | National Institute on Aging |
| awards[2].id | https://openalex.org/G7782041359 |
| awards[2].funder_id | https://openalex.org/F4320337337 |
| awards[2].display_name | |
| awards[2].funder_award_id | R01AG050676 |
| awards[2].funder_display_name | National Institute on Aging |
| biblio.issue | 1 |
| biblio.volume | 4 |
| biblio.last_page | 89 |
| biblio.first_page | 75 |
| topics[0].id | https://openalex.org/T10301 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9994999766349792 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Mitochondrial Function and Pathology |
| topics[1].id | https://openalex.org/T11457 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9990000128746033 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2737 |
| topics[1].subfield.display_name | Physiology |
| topics[1].display_name | Adipose Tissue and Metabolism |
| topics[2].id | https://openalex.org/T10587 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9983999729156494 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Autophagy in Disease and Therapy |
| funders[0].id | https://openalex.org/F4320337337 |
| funders[0].ror | https://ror.org/049v75w11 |
| funders[0].display_name | National Institute on Aging |
| is_xpac | False |
| apc_list.value | 1875 |
| apc_list.currency | USD |
| apc_list.value_usd | 1875 |
| apc_paid.value | 1875 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 1875 |
| concepts[0].id | https://openalex.org/C2777399203 |
| concepts[0].level | 4 |
| concepts[0].score | 0.6809142231941223 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q185253 |
| concepts[0].display_name | Adenosine diphosphate |
| concepts[1].id | https://openalex.org/C48349386 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6693094968795776 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q424361 |
| concepts[1].display_name | Reactive oxygen species |
| concepts[2].id | https://openalex.org/C126322002 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6441142559051514 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[2].display_name | Internal medicine |
| concepts[3].id | https://openalex.org/C2778175917 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6013994812965393 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q17125553 |
| concepts[3].display_name | Mitochondrial ROS |
| concepts[4].id | https://openalex.org/C2776151105 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6011289954185486 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q898814 |
| concepts[4].display_name | Oxidative stress |
| concepts[5].id | https://openalex.org/C28859421 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5973799228668213 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q39572 |
| concepts[5].display_name | Mitochondrion |
| concepts[6].id | https://openalex.org/C134018914 |
| concepts[6].level | 1 |
| concepts[6].score | 0.5930215716362 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[6].display_name | Endocrinology |
| concepts[7].id | https://openalex.org/C2779959927 |
| concepts[7].level | 2 |
| concepts[7].score | 0.574820876121521 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1048687 |
| concepts[7].display_name | Skeletal muscle |
| concepts[8].id | https://openalex.org/C2776805190 |
| concepts[8].level | 2 |
| concepts[8].score | 0.5424872040748596 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1187030 |
| concepts[8].display_name | Denervation |
| concepts[9].id | https://openalex.org/C2779564974 |
| concepts[9].level | 2 |
| concepts[9].score | 0.5225531458854675 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q80863 |
| concepts[9].display_name | Adenosine triphosphate |
| concepts[10].id | https://openalex.org/C185592680 |
| concepts[10].level | 0 |
| concepts[10].score | 0.45953062176704407 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[10].display_name | Chemistry |
| concepts[11].id | https://openalex.org/C57600042 |
| concepts[11].level | 2 |
| concepts[11].score | 0.4389810562133789 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q227564 |
| concepts[11].display_name | Oxidative phosphorylation |
| concepts[12].id | https://openalex.org/C20251656 |
| concepts[12].level | 3 |
| concepts[12].score | 0.4352065920829773 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q162643 |
| concepts[12].display_name | Glycolysis |
| concepts[13].id | https://openalex.org/C2776991684 |
| concepts[13].level | 2 |
| concepts[13].score | 0.4207334816455841 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q190012 |
| concepts[13].display_name | Adenosine |
| concepts[14].id | https://openalex.org/C100206155 |
| concepts[14].level | 3 |
| concepts[14].score | 0.4128114581108093 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q570714 |
| concepts[14].display_name | Bioenergetics |
| concepts[15].id | https://openalex.org/C86803240 |
| concepts[15].level | 0 |
| concepts[15].score | 0.3802282214164734 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[15].display_name | Biology |
| concepts[16].id | https://openalex.org/C55493867 |
| concepts[16].level | 1 |
| concepts[16].score | 0.36703938245773315 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[16].display_name | Biochemistry |
| concepts[17].id | https://openalex.org/C62231903 |
| concepts[17].level | 2 |
| concepts[17].score | 0.1643957495689392 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q1057 |
| concepts[17].display_name | Metabolism |
| concepts[18].id | https://openalex.org/C71924100 |
| concepts[18].level | 0 |
| concepts[18].score | 0.13503021001815796 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[18].display_name | Medicine |
| concepts[19].id | https://openalex.org/C89560881 |
| concepts[19].level | 2 |
| concepts[19].score | 0.11644354462623596 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q101026 |
| concepts[19].display_name | Platelet |
| concepts[20].id | https://openalex.org/C2993802102 |
| concepts[20].level | 3 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q101026 |
| concepts[20].display_name | Platelet aggregation |
| keywords[0].id | https://openalex.org/keywords/adenosine-diphosphate |
| keywords[0].score | 0.6809142231941223 |
| keywords[0].display_name | Adenosine diphosphate |
| keywords[1].id | https://openalex.org/keywords/reactive-oxygen-species |
| keywords[1].score | 0.6693094968795776 |
| keywords[1].display_name | Reactive oxygen species |
| keywords[2].id | https://openalex.org/keywords/internal-medicine |
| keywords[2].score | 0.6441142559051514 |
| keywords[2].display_name | Internal medicine |
| keywords[3].id | https://openalex.org/keywords/mitochondrial-ros |
| keywords[3].score | 0.6013994812965393 |
| keywords[3].display_name | Mitochondrial ROS |
| keywords[4].id | https://openalex.org/keywords/oxidative-stress |
| keywords[4].score | 0.6011289954185486 |
| keywords[4].display_name | Oxidative stress |
| keywords[5].id | https://openalex.org/keywords/mitochondrion |
| keywords[5].score | 0.5973799228668213 |
| keywords[5].display_name | Mitochondrion |
| keywords[6].id | https://openalex.org/keywords/endocrinology |
| keywords[6].score | 0.5930215716362 |
| keywords[6].display_name | Endocrinology |
| keywords[7].id | https://openalex.org/keywords/skeletal-muscle |
| keywords[7].score | 0.574820876121521 |
| keywords[7].display_name | Skeletal muscle |
| keywords[8].id | https://openalex.org/keywords/denervation |
| keywords[8].score | 0.5424872040748596 |
| keywords[8].display_name | Denervation |
| keywords[9].id | https://openalex.org/keywords/adenosine-triphosphate |
| keywords[9].score | 0.5225531458854675 |
| keywords[9].display_name | Adenosine triphosphate |
| keywords[10].id | https://openalex.org/keywords/chemistry |
| keywords[10].score | 0.45953062176704407 |
| keywords[10].display_name | Chemistry |
| keywords[11].id | https://openalex.org/keywords/oxidative-phosphorylation |
| keywords[11].score | 0.4389810562133789 |
| keywords[11].display_name | Oxidative phosphorylation |
| keywords[12].id | https://openalex.org/keywords/glycolysis |
| keywords[12].score | 0.4352065920829773 |
| keywords[12].display_name | Glycolysis |
| keywords[13].id | https://openalex.org/keywords/adenosine |
| keywords[13].score | 0.4207334816455841 |
| keywords[13].display_name | Adenosine |
| keywords[14].id | https://openalex.org/keywords/bioenergetics |
| keywords[14].score | 0.4128114581108093 |
| keywords[14].display_name | Bioenergetics |
| keywords[15].id | https://openalex.org/keywords/biology |
| keywords[15].score | 0.3802282214164734 |
| keywords[15].display_name | Biology |
| keywords[16].id | https://openalex.org/keywords/biochemistry |
| keywords[16].score | 0.36703938245773315 |
| keywords[16].display_name | Biochemistry |
| keywords[17].id | https://openalex.org/keywords/metabolism |
| keywords[17].score | 0.1643957495689392 |
| keywords[17].display_name | Metabolism |
| keywords[18].id | https://openalex.org/keywords/medicine |
| keywords[18].score | 0.13503021001815796 |
| keywords[18].display_name | Medicine |
| keywords[19].id | https://openalex.org/keywords/platelet |
| keywords[19].score | 0.11644354462623596 |
| keywords[19].display_name | Platelet |
| language | en |
| locations[0].id | doi:10.1002/rco2.29 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210235589 |
| locations[0].source.issn | 2617-1619 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2617-1619 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | JCSM Rapid Communications |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | JCSM Rapid Communications |
| locations[0].landing_page_url | https://doi.org/10.1002/rco2.29 |
| locations[1].id | pmid:36159599 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | JCSM rapid communications |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/36159599 |
| locations[2].id | pmh:oai:doaj.org/article:c9d73ee999be4822bd37c746dcd9070e |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | JCSM Rapid Communications, Vol 4, Iss 1, Pp 75-89 (2021) |
| locations[2].landing_page_url | https://doaj.org/article/c9d73ee999be4822bd37c746dcd9070e |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9503137 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | JCSM Rapid Commun |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9503137 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5084280551 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-7221-7346 |
| authorships[0].author.display_name | Gavin Pharaoh |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I49332381 |
| authorships[0].affiliations[0].raw_affiliation_string | Physiology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I30558944 |
| authorships[0].affiliations[1].raw_affiliation_string | Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA |
| authorships[0].institutions[0].id | https://openalex.org/I30558944 |
| authorships[0].institutions[0].ror | https://ror.org/035z6xf33 |
| authorships[0].institutions[0].type | nonprofit |
| authorships[0].institutions[0].lineage | https://openalex.org/I30558944 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Oklahoma Medical Research Foundation |
| authorships[0].institutions[1].id | https://openalex.org/I49332381 |
| authorships[0].institutions[1].ror | https://ror.org/0457zbj98 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I49332381 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | University of Oklahoma Health Sciences Center |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Gavin Pharaoh |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, Physiology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| authorships[1].author.id | https://openalex.org/A5031158609 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-0912-7924 |
| authorships[1].author.display_name | Jacob L. Brown |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I30558944 |
| authorships[1].affiliations[0].raw_affiliation_string | Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA |
| authorships[1].institutions[0].id | https://openalex.org/I30558944 |
| authorships[1].institutions[0].ror | https://ror.org/035z6xf33 |
| authorships[1].institutions[0].type | nonprofit |
| authorships[1].institutions[0].lineage | https://openalex.org/I30558944 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Oklahoma Medical Research Foundation |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Jacob Brown |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA |
| authorships[2].author.id | https://openalex.org/A5031766945 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Rojina Ranjit |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I30558944 |
| authorships[2].affiliations[0].raw_affiliation_string | Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA |
| authorships[2].institutions[0].id | https://openalex.org/I30558944 |
| authorships[2].institutions[0].ror | https://ror.org/035z6xf33 |
| authorships[2].institutions[0].type | nonprofit |
| authorships[2].institutions[0].lineage | https://openalex.org/I30558944 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Oklahoma Medical Research Foundation |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Rojina Ranjit |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA |
| authorships[3].author.id | https://openalex.org/A5020830848 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-6035-6039 |
| authorships[3].author.display_name | Zoltán Ungvári |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I49332381 |
| authorships[3].affiliations[0].raw_affiliation_string | Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I49332381 |
| authorships[3].affiliations[1].raw_affiliation_string | Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| authorships[3].institutions[0].id | https://openalex.org/I49332381 |
| authorships[3].institutions[0].ror | https://ror.org/0457zbj98 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I49332381 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | University of Oklahoma Health Sciences Center |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Zoltan Ungvari |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| authorships[4].author.id | https://openalex.org/A5000765673 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-0883-0642 |
| authorships[4].author.display_name | Holly Van Remmen |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I30558944 |
| authorships[4].affiliations[0].raw_affiliation_string | Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I4210099251 |
| authorships[4].affiliations[1].raw_affiliation_string | Oklahoma City VA Medical Center, Oklahoma City, OK, USA |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I49332381 |
| authorships[4].affiliations[2].raw_affiliation_string | Physiology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| authorships[4].affiliations[3].institution_ids | https://openalex.org/I49332381 |
| authorships[4].affiliations[3].raw_affiliation_string | Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| authorships[4].institutions[0].id | https://openalex.org/I4210099251 |
| authorships[4].institutions[0].ror | https://ror.org/010md9d18 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I1322918889, https://openalex.org/I2799886695, https://openalex.org/I4210099251, https://openalex.org/I4210113540, https://openalex.org/I4210133336 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Oklahoma City VA Medical Center |
| authorships[4].institutions[1].id | https://openalex.org/I30558944 |
| authorships[4].institutions[1].ror | https://ror.org/035z6xf33 |
| authorships[4].institutions[1].type | nonprofit |
| authorships[4].institutions[1].lineage | https://openalex.org/I30558944 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | Oklahoma Medical Research Foundation |
| authorships[4].institutions[2].id | https://openalex.org/I49332381 |
| authorships[4].institutions[2].ror | https://ror.org/0457zbj98 |
| authorships[4].institutions[2].type | healthcare |
| authorships[4].institutions[2].lineage | https://openalex.org/I49332381 |
| authorships[4].institutions[2].country_code | US |
| authorships[4].institutions[2].display_name | University of Oklahoma Health Sciences Center |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Holly Van Remmen |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA, Oklahoma City VA Medical Center, Oklahoma City, OK, USA, Physiology Department, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1002/rco2.29 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10301 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9994999766349792 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Mitochondrial Function and Pathology |
| related_works | https://openalex.org/W2188876885, https://openalex.org/W2043628621, https://openalex.org/W2412310545, https://openalex.org/W2082779612, https://openalex.org/W2049901117, https://openalex.org/W2045238890, https://openalex.org/W2410145676, https://openalex.org/W4235460042, https://openalex.org/W2065670690, https://openalex.org/W2063253626 |
| cited_by_count | 22 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 9 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 7 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1002/rco2.29 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210235589 |
| best_oa_location.source.issn | 2617-1619 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2617-1619 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | JCSM Rapid Communications |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_lineage_names | Wiley |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | JCSM Rapid Communications |
| best_oa_location.landing_page_url | https://doi.org/10.1002/rco2.29 |
| primary_location.id | doi:10.1002/rco2.29 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210235589 |
| primary_location.source.issn | 2617-1619 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2617-1619 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | JCSM Rapid Communications |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | JCSM Rapid Communications |
| primary_location.landing_page_url | https://doi.org/10.1002/rco2.29 |
| publication_date | 2020-12-28 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W2110839189, https://openalex.org/W1500093205, https://openalex.org/W2000448207, https://openalex.org/W2126525177, https://openalex.org/W2146350530, https://openalex.org/W2110957605, https://openalex.org/W2066734635, https://openalex.org/W2007891985, https://openalex.org/W2103083285, https://openalex.org/W1623884054, https://openalex.org/W1600619258, https://openalex.org/W2789587938, https://openalex.org/W1988744799, https://openalex.org/W2049338248, https://openalex.org/W1701470710, https://openalex.org/W2047232246, https://openalex.org/W2137182040, https://openalex.org/W2040751146, https://openalex.org/W2908316563, https://openalex.org/W2132098985, https://openalex.org/W2068395411, https://openalex.org/W2075566081, https://openalex.org/W2046854924, https://openalex.org/W2087431155, https://openalex.org/W1722845210, https://openalex.org/W2512845699, https://openalex.org/W3036525701, https://openalex.org/W1995763327, https://openalex.org/W3064388424, https://openalex.org/W1833567598, https://openalex.org/W2069867390, https://openalex.org/W2796184213, https://openalex.org/W2747213856, https://openalex.org/W2580932923, https://openalex.org/W2132285515, https://openalex.org/W1766184155, https://openalex.org/W2082798387, https://openalex.org/W2947428526, https://openalex.org/W2885127049, https://openalex.org/W2035499535, https://openalex.org/W2003811137, https://openalex.org/W2765244546, https://openalex.org/W4210476467 |
| referenced_works_count | 43 |
| abstract_inverted_index.( | 92 |
| abstract_inverted_index.a | 221, 238 |
| abstract_inverted_index.We | 45, 67 |
| abstract_inverted_index.an | 56 |
| abstract_inverted_index.at | 24, 77 |
| abstract_inverted_index.be | 253 |
| abstract_inverted_index.do | 218 |
| abstract_inverted_index.in | 31, 40, 51, 70, 73, 86, 111, 125, 129, 160, 209, 223, 237 |
| abstract_inverted_index.is | 121, 150, 235 |
| abstract_inverted_index.no | 151 |
| abstract_inverted_index.of | 153, 176, 240, 258 |
| abstract_inverted_index.on | 155 |
| abstract_inverted_index.or | 173 |
| abstract_inverted_index.to | 6, 88, 140, 198, 233, 247 |
| abstract_inverted_index.we | 36, 97 |
| abstract_inverted_index.ADP | 26, 29, 38, 57, 71, 106, 119, 156, 167, 183, 229, 234, 243 |
| abstract_inverted_index.O2k | 63 |
| abstract_inverted_index.OCR | 47, 159, 187 |
| abstract_inverted_index.ROS | 49, 127, 142, 171, 192, 206 |
| abstract_inverted_index.The | 137 |
| abstract_inverted_index.age | 154 |
| abstract_inverted_index.and | 16, 48, 60, 65, 85, 108, 132, 148, 188, 195, 250 |
| abstract_inverted_index.are | 4, 22 |
| abstract_inverted_index.can | 104 |
| abstract_inverted_index.for | 158, 169, 185, 205 |
| abstract_inverted_index.may | 252 |
| abstract_inverted_index.not | 144, 165, 219, 227 |
| abstract_inverted_index.the | 61, 100, 112, 254 |
| abstract_inverted_index.OCR. | 174, 224 |
| abstract_inverted_index.ROS, | 189 |
| abstract_inverted_index.Sod1 | 93, 113, 133, 177 |
| abstract_inverted_index.age, | 147 |
| abstract_inverted_index.aged | 32, 130, 210, 216 |
| abstract_inverted_index.both | 186 |
| abstract_inverted_index.does | 143, 164, 226 |
| abstract_inverted_index.drug | 256 |
| abstract_inverted_index.from | 75 |
| abstract_inverted_index.mice | 76, 179, 217 |
| abstract_inverted_index.rate | 20 |
| abstract_inverted_index.this | 260 |
| abstract_inverted_index.with | 123, 146, 180 |
| abstract_inverted_index.(33%) | 135 |
| abstract_inverted_index.(62%) | 131 |
| abstract_inverted_index.(ADP) | 9 |
| abstract_inverted_index.(ROS) | 14 |
| abstract_inverted_index.(i.e. | 28 |
| abstract_inverted_index.Here, | 35 |
| abstract_inverted_index.after | 80 |
| abstract_inverted_index.ages, | 79 |
| abstract_inverted_index.aging | 261 |
| abstract_inverted_index.asked | 98 |
| abstract_inverted_index.could | 245 |
| abstract_inverted_index.first | 255 |
| abstract_inverted_index.human | 33 |
| abstract_inverted_index.mice. | 136 |
| abstract_inverted_index.model | 239 |
| abstract_inverted_index.mouse | 41, 115, 161, 211 |
| abstract_inverted_index.nerve | 82 |
| abstract_inverted_index.there | 149 |
| abstract_inverted_index.using | 55 |
| abstract_inverted_index.(OCR)] | 21 |
| abstract_inverted_index.effect | 152 |
| abstract_inverted_index.either | 170 |
| abstract_inverted_index.fibres | 54 |
| abstract_inverted_index.induce | 166, 228 |
| abstract_inverted_index.mice). | 95 |
| abstract_inverted_index.model. | 116 |
| abstract_inverted_index.muscle | 42, 74, 199, 213, 248 |
| abstract_inverted_index.oxygen | 12 |
| abstract_inverted_index.stress | 91 |
| abstract_inverted_index.(~40%), | 194 |
| abstract_inverted_index.Methods | 44 |
| abstract_inverted_index.Reduced | 118 |
| abstract_inverted_index.Results | 117 |
| abstract_inverted_index.SS‐31 | 103, 181, 251 |
| abstract_inverted_index.[oxygen | 18 |
| abstract_inverted_index.altered | 23 |
| abstract_inverted_index.capable | 257 |
| abstract_inverted_index.changes | 69 |
| abstract_inverted_index.exhibit | 220 |
| abstract_inverted_index.fibres, | 214 |
| abstract_inverted_index.induced | 236 |
| abstract_inverted_index.maximal | 138, 191 |
| abstract_inverted_index.muscle. | 34 |
| abstract_inverted_index.peptide | 102 |
| abstract_inverted_index.produce | 141 |
| abstract_inverted_index.sciatic | 81 |
| abstract_inverted_index.species | 13 |
| abstract_inverted_index.stress. | 242 |
| abstract_inverted_index.whether | 99 |
| abstract_inverted_index.−/− | 94, 114, 134, 178 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Further, | 96 |
| abstract_inverted_index.Oroboros | 62 |
| abstract_inverted_index.Reactive | 11 |
| abstract_inverted_index.although | 215 |
| abstract_inverted_index.capacity | 139 |
| abstract_inverted_index.fatigue, | 249 |
| abstract_inverted_index.fatigue. | 200 |
| abstract_inverted_index.function | 110 |
| abstract_inverted_index.however, | 231 |
| abstract_inverted_index.improves | 196 |
| abstract_inverted_index.increase | 145 |
| abstract_inverted_index.measured | 46, 68 |
| abstract_inverted_index.modulate | 105 |
| abstract_inverted_index.protocol | 59 |
| abstract_inverted_index.response | 87 |
| abstract_inverted_index.Adenosine | 202 |
| abstract_inverted_index.Treatment | 175 |
| abstract_inverted_index.adenosine | 7 |
| abstract_inverted_index.decreases | 190, 208 |
| abstract_inverted_index.different | 78 |
| abstract_inverted_index.increased | 89 |
| abstract_inverted_index.increases | 124, 182 |
| abstract_inverted_index.oxidative | 90, 241 |
| abstract_inverted_index.sensitive | 5 |
| abstract_inverted_index.targeting | 259 |
| abstract_inverted_index.titration | 58 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.associated | 122 |
| abstract_inverted_index.contribute | 246 |
| abstract_inverted_index.difference | 222 |
| abstract_inverted_index.generation | 172 |
| abstract_inverted_index.phenotype. | 262 |
| abstract_inverted_index.production | 15, 50, 128, 193, 207 |
| abstract_inverted_index.resistance | 197 |
| abstract_inverted_index.Conclusions | 201 |
| abstract_inverted_index.Denervation | 163, 225 |
| abstract_inverted_index.consumption | 19 |
| abstract_inverted_index.contractile | 109 |
| abstract_inverted_index.diphosphate | 8, 203 |
| abstract_inverted_index.investigate | 37 |
| abstract_inverted_index.respiration | 17 |
| abstract_inverted_index.sensitivity | 39, 72, 120, 157, 184, 204 |
| abstract_inverted_index.transection | 83 |
| abstract_inverted_index.fluorometer. | 66 |
| abstract_inverted_index.respirometer | 64 |
| abstract_inverted_index.Mitochondrial | 2 |
| abstract_inverted_index.bioenergetics | 3 |
| abstract_inverted_index.gastrocnemii. | 162 |
| abstract_inverted_index.gastrocnemius | 53, 212 |
| abstract_inverted_index.insensitivity | 107, 168, 232, 244 |
| abstract_inverted_index.mitochondria. | 43 |
| abstract_inverted_index.mitochondrial | 126 |
| abstract_inverted_index.permeabilized | 52 |
| abstract_inverted_index.physiological | 25 |
| abstract_inverted_index.(denervation), | 84 |
| abstract_inverted_index.concentration. | 10 |
| abstract_inverted_index.concentrations | 27 |
| abstract_inverted_index.insensitivity) | 30 |
| abstract_inverted_index.insensitivity; | 230 |
| abstract_inverted_index.mitochondrial‐targeted | 101 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5000765673 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I30558944, https://openalex.org/I4210099251, https://openalex.org/I49332381 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/6 |
| sustainable_development_goals[0].score | 0.4000000059604645 |
| sustainable_development_goals[0].display_name | Clean water and sanitation |
| citation_normalized_percentile.value | 0.70268009 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |