Reduced glymphatic function after traumatic brain injury measured using diffusion MRI Article Swipe
Tracy Butler
,
Liangdong Zhou
,
Ilker Ozhasin
,
Xiuyuan Hugh Wang
,
Jacob Garretti
,
Henrik Zetterberg
,
Kai Blennow
,
Keith Jamison
,
Mony J. de Leon
,
Yi Li
,
Amy Kuceyeski
,
Sudhin A. Shah
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.11.05.22281969
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.11.05.22281969
The glymphatic system is a perivascular fluid clearance system, most active during sleep, considered important for clearing the brain of waste products and toxins. Glymphatic failure is hypothesized to underlie brain protein deposition in neurodegenerative disorders like Alzheimer’s Disease. Preclinical evidence suggests that a functioning glymphatic system is also essential for recovery from traumatic brain injury (TBI), which involves release of debris and toxic proteins that need to be cleared from the brain. We estimated glymphatic clearance using Diffusion Tensor Imaging Along Perivascular Spaces (DTI-ALPS), an MRI-derived measure of water diffusivity surrounding veins, in 13 non-injured controls and 37 subjects with TBI (∼5 months post). We additionally measured plasma concentrations of Neurofilament light chain (NfL), a biomarker of injury severity, in a subset of subjects. DTI-ALPS was significantly lower in TBI subjects compared to controls, after controlling for age, and significantly, negatively correlated with NfL. Glymphatic impairment after TBI could be due to mechanisms such as mis-localization of glymphatic water channels, inflammation, proteinopathy and/or sleep disruption. Additional work, including longitudinal studies, are needed to confirm results and assess glymphatic associations with outcome. Understanding post-TBI glymphatic functioning could inform novel therapies to improve short-term recovery and reduce later risk of neurodegeneration.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.11.05.22281969
- https://www.medrxiv.org/content/medrxiv/early/2022/11/10/2022.11.05.22281969.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4308713920
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4308713920Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.11.05.22281969Digital Object Identifier
- Title
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Reduced glymphatic function after traumatic brain injury measured using diffusion MRIWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-11-10Full publication date if available
- Authors
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Tracy Butler, Liangdong Zhou, Ilker Ozhasin, Xiuyuan Hugh Wang, Jacob Garretti, Henrik Zetterberg, Kai Blennow, Keith Jamison, Mony J. de Leon, Yi Li, Amy Kuceyeski, Sudhin A. ShahList of authors in order
- Landing page
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https://doi.org/10.1101/2022.11.05.22281969Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2022/11/10/2022.11.05.22281969.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2022/11/10/2022.11.05.22281969.full.pdfDirect OA link when available
- Concepts
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Glymphatic system, Traumatic brain injury, Medicine, Biomarker, Diffusion MRI, Neurodegeneration, Pathology, Neuroscience, Cerebrospinal fluid, Psychology, Magnetic resonance imaging, Disease, Chemistry, Radiology, Psychiatry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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