Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability Article Swipe

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Marian H. Hettiaratchi , Matthew J. O’Meara , Teresa R. O’Meara , Andrew Pickering , Nitzan Letko-Khait , Molly S. Shoichet ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.1126/sciadv.abc6378

Computational redesign of chondroitinase ABC introduces 37 point mutations to improve enzyme stability and activity.

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Business Process Re-Engineering

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Business process reengineering Biochemical engineering Computer science Biotechnology Chemistry Biology Engineering Organic chemistry Oil refinery

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Type: article
Language: en
Landing Page: https://doi.org/10.1126/sciadv.abc6378
OA Status: gold
Cited By: 48
References: 53
Related Works: 10
OpenAlex ID: https://openalex.org/W3061328166

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DOI: https://doi.org/10.1126/sciadv.abc6378

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Title: Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability

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Type: article

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Language: en

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Publication year: 2020

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Publication date: 2020-08-19

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Authors: Marian H. Hettiaratchi, Matthew J. O’Meara, Teresa R. O’Meara, Andrew Pickering, Nitzan Letko-Khait, Molly S. Shoichet

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Landing page: https://doi.org/10.1126/sciadv.abc6378

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OA status: gold

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Concepts: Business process reengineering, Biochemical engineering, Computer science, Biotechnology, Chemistry, Biology, Engineering, Organic chemistry, Oil refinery

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Cited by: 48

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References (count): 53

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referenced_works	https://openalex.org/W2090000200, https://openalex.org/W2145775566, https://openalex.org/W2913211528, https://openalex.org/W2116378996, https://openalex.org/W1964919865, https://openalex.org/W2901741366, https://openalex.org/W2901405426, https://openalex.org/W2012928251, https://openalex.org/W1983891257, https://openalex.org/W2951581350, https://openalex.org/W2052561315, https://openalex.org/W2034289055, https://openalex.org/W2151887741, https://openalex.org/W2473135273, https://openalex.org/W2903887467, https://openalex.org/W2060194574, https://openalex.org/W2081421232, https://openalex.org/W2017636720, https://openalex.org/W2078340394, https://openalex.org/W1987032391, https://openalex.org/W2015746898, https://openalex.org/W2570705548, https://openalex.org/W2001210310, https://openalex.org/W2165026145, https://openalex.org/W1967181972, https://openalex.org/W2066612220, https://openalex.org/W2415067039, https://openalex.org/W2605779242, https://openalex.org/W1986172952, https://openalex.org/W2430718227, https://openalex.org/W1983410669, https://openalex.org/W2089089729, https://openalex.org/W3016142056, https://openalex.org/W2898402099, https://openalex.org/W2158714788, https://openalex.org/W2132926880, https://openalex.org/W2123850444, https://openalex.org/W2140260269, https://openalex.org/W2112504441, https://openalex.org/W2008708467, https://openalex.org/W4254687493, https://openalex.org/W2026853280, https://openalex.org/W1957571292, https://openalex.org/W2336269502, https://openalex.org/W2750122912, https://openalex.org/W2625271746, https://openalex.org/W2796011323, https://openalex.org/W2768438172, https://openalex.org/W2804499844, https://openalex.org/W2945312610, https://openalex.org/W2938574745, https://openalex.org/W255996521, https://openalex.org/W1587026990
referenced_works_count	53
abstract_inverted_index.37	6
abstract_inverted_index.of	2
abstract_inverted_index.to	9
abstract_inverted_index.ABC	4
abstract_inverted_index.and	13
abstract_inverted_index.point	7
abstract_inverted_index.enzyme	11
abstract_inverted_index.improve	10
abstract_inverted_index.redesign	1
abstract_inverted_index.activity.	14
abstract_inverted_index.mutations	8
abstract_inverted_index.stability	12
abstract_inverted_index.introduces	5
abstract_inverted_index.Computational	0
abstract_inverted_index.chondroitinase	3
cited_by_percentile_year.max	100
cited_by_percentile_year.min	98
corresponding_author_ids	https://openalex.org/A5045900479, https://openalex.org/A5002654936, https://openalex.org/A5028705544
countries_distinct_count	2
institutions_distinct_count	6
corresponding_institution_ids	https://openalex.org/I185261750, https://openalex.org/I199037182, https://openalex.org/I27837315
citation_normalized_percentile.value	0.90071207
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True