Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMI Article Swipe
Martin S. Lietzén
,
Maria Angela Guzzardi
,
Ronja Ojala
,
Jaakko Hentilä
,
Marja A. Heiskanen
,
Sanna M. Honkala
,
Riikka Läutamaki
,
Eliisa Löyttyniemi
,
Anna K. Kirjavainen
,
Johan Rajander
,
Tarja Malm
,
Leo Lahti
,
Juha O. Rinne
,
Kirsi H. Pietiläinen
,
Patricia Iozzo
,
Jarna C. Hannukainen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/nu16203554
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/nu16203554
Background/Objectives: Obesity impairs intestinal glucose uptake (GU) (intestinal uptake of circulating glucose from blood) and alters gut microbiome. Exercise improves intestinal insulin-stimulated GU and alters microbiome. Genetics influence the risk of obesity and gut microbiome. However, the role of genetics on the effects of exercise on intestinal GU and microbiome is unclear. Methods: Twelve monozygotic twin pairs discordant for BMI (age 40.4 ± 4.5 years, BMI heavier 36.7 ± 6.0, leaner 29.1 ± 5.7, 8 female pairs) performed a six-month-long training intervention. Small intestine and colonic insulin-stimulated GU was studied using [18F]FDG-PET and microbiota from fecal samples with 16s rRNA. Results: Ten pairs completed the intervention. At baseline, heavier twins had lower small intestine and colonic GU (p < 0.05). Response to exercise differed between twins (p = 0.05), with leaner twins increasing colonic GU. Alpha and beta diversity did not differ at baseline. During the intervention, beta diversity changed significantly, most prominently at the mid-point (p < 0.01). Beta diversity changes were only significant in the leaner twins when the twin groups were analyzed separately. Exercise was associated with changes at the phylum level, mainly at the mid-point (pFDR < 0.05); at the genus level, several microbes increased, such as Lactobacillus and Sellimonas (pFDR < 0.05). In type 1 analyses, many genera changes were associated with exercise, and fewer, such as Lactobacillus, were also associated with dietary sugar consumption (p < 0.05). Conclusions: Obesity impairs insulin-stimulated intestinal GU independent of genetics. Though both twin groups exhibited some microbiota changes, most changes in insulin-stimulated colon GU and microbiota were significant in the leaner twins.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu16203554
- OA Status
- gold
- Cited By
- 2
- References
- 75
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403605033
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403605033Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nu16203554Digital Object Identifier
- Title
-
Regular Exercise Training Induces More Changes on Intestinal Glucose Uptake from Blood and Microbiota Composition in Leaner Compared to Heavier Individuals in Monozygotic Twins Discordant for BMIWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-20Full publication date if available
- Authors
-
Martin S. Lietzén, Maria Angela Guzzardi, Ronja Ojala, Jaakko Hentilä, Marja A. Heiskanen, Sanna M. Honkala, Riikka Läutamaki, Eliisa Löyttyniemi, Anna K. Kirjavainen, Johan Rajander, Tarja Malm, Leo Lahti, Juha O. Rinne, Kirsi H. Pietiläinen, Patricia Iozzo, Jarna C. HannukainenList of authors in order
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https://doi.org/10.3390/nu16203554Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/nu16203554Direct OA link when available
- Concepts
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Microbiome, Obesity, Gut microbiome, Intestinal Microbiome, Endocrinology, Physiology, Internal medicine, Biology, Medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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75Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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