Regulation of BMP Signaling by O-GlcNAcylation Article Swipe
Matthew J. Moulton
,
G. O. Humphreys
,
Alexander Kim
,
Anthea Letsou
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/784629
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/784629
Summary Precise regulation of signal transduction is critical throughout organismal life, both for embryonic development and for adult homeostasis. To ensure proper spatio-temporal signal transduction, Bone Morphogenetic Protein (BMP) signaling pathways, like all other signaling pathways, are regulated by both agonists and antagonists. Here, we report identification of a previously unrecognized method of signal antagonism for Dpp (Decapentaplegic), a Drosophila BMP family member. We demonstrate that the BMP type I receptor Saxophone (Sax) functions as a Dpp receptor in the Drosophila embryonic epidermis, but that its activity is normally inhibited by the O-linked glycosyltransferase Super sex combs (Sxc). In wild-type embryos, inhibition of Saxophone (Sax) activity in the epidermis marks the BMP type I receptor Thickveins (Tkv) as the sole conduit for Dpp. In contrast, in sxc mutants, the Dpp signal is transduced by both Tkv and Sax, and elevated Dpp signaling induces errors in embryonic development that lead to embryonic death. We also demonstrate that Sax is the O-glycosylated target of Sxc and that O-glycosylation of Sax can be modulated by dietary sugar. Together, these findings link fertility to nutritive environment and point to Sax (activin receptor-like kinase 2 [ACVR1 or ALK2]) signaling as the nutrient-sensitive branch of BMP signaling. Graphical Abstract
Related Topics
Concepts
Signal transduction
Bone morphogenetic protein
Cell biology
Decapentaplegic
Biology
Noggin
Receptor
Embryonic stem cell
BMPR2
Mutant
Genetics
Gene
Imaginal disc
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/784629
- https://www.biorxiv.org/content/biorxiv/early/2020/01/16/784629.full.pdf
- OA Status
- green
- References
- 104
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2976580492
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2976580492Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/784629Digital Object Identifier
- Title
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Regulation of BMP Signaling by O-GlcNAcylationWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-09-27Full publication date if available
- Authors
-
Matthew J. Moulton, G. O. Humphreys, Alexander Kim, Anthea LetsouList of authors in order
- Landing page
-
https://doi.org/10.1101/784629Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2020/01/16/784629.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2020/01/16/784629.full.pdfDirect OA link when available
- Concepts
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Signal transduction, Bone morphogenetic protein, Cell biology, Decapentaplegic, Biology, Noggin, Receptor, Embryonic stem cell, BMPR2, Mutant, Genetics, Gene, Imaginal discTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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104Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2625396153, https://openalex.org/W2952640964, https://openalex.org/W2022781536, https://openalex.org/W2128652025, https://openalex.org/W2091318688, https://openalex.org/W2046852564, https://openalex.org/W2098757098, https://openalex.org/W2018857251, https://openalex.org/W2120036668, https://openalex.org/W2016232806, https://openalex.org/W1956617534, https://openalex.org/W2181592269, https://openalex.org/W1966116042, https://openalex.org/W1970662326, https://openalex.org/W2092439777, https://openalex.org/W2031400949, https://openalex.org/W2469664870, https://openalex.org/W107544894, https://openalex.org/W2258927423, https://openalex.org/W1968538228, https://openalex.org/W2069879083, https://openalex.org/W1975678442, https://openalex.org/W2038011324, https://openalex.org/W2079074163, https://openalex.org/W1983636721, https://openalex.org/W2183101699, https://openalex.org/W2063692873, https://openalex.org/W2089613312, https://openalex.org/W1522904209, https://openalex.org/W2140409722, https://openalex.org/W2765316290, https://openalex.org/W2065582003, https://openalex.org/W2079977692, https://openalex.org/W2069467774, https://openalex.org/W2016089890, https://openalex.org/W2026939821, https://openalex.org/W1861025206, https://openalex.org/W1972732131, https://openalex.org/W2131996545, https://openalex.org/W4211160592, https://openalex.org/W2027578698, https://openalex.org/W2117924228, https://openalex.org/W1600300638, https://openalex.org/W1980635877, https://openalex.org/W2112921913, https://openalex.org/W6745611841, https://openalex.org/W2767487493, https://openalex.org/W1927573020, https://openalex.org/W2102648383, https://openalex.org/W2747147211, https://openalex.org/W2963392371, https://openalex.org/W2113150782, https://openalex.org/W2002248474, https://openalex.org/W2097711466, https://openalex.org/W2795327269, https://openalex.org/W2103031848, https://openalex.org/W2093797314, https://openalex.org/W1637612807, https://openalex.org/W2325070411, https://openalex.org/W2035375262, https://openalex.org/W2115340713, https://openalex.org/W2137404591, https://openalex.org/W2081689397, https://openalex.org/W1973812449, https://openalex.org/W2883048904, https://openalex.org/W1979733685, https://openalex.org/W2766200583, https://openalex.org/W2024407301, https://openalex.org/W1978489579, https://openalex.org/W4229874199, https://openalex.org/W2015877043, https://openalex.org/W1974584117, https://openalex.org/W2039295111, https://openalex.org/W2036019393, https://openalex.org/W2552892604, https://openalex.org/W1993953064, https://openalex.org/W2096557906, https://openalex.org/W2028605179, https://openalex.org/W1971127837, https://openalex.org/W2114579362, https://openalex.org/W2081891357, https://openalex.org/W2469055008, https://openalex.org/W1972509609, https://openalex.org/W2154767933, https://openalex.org/W1900546667, https://openalex.org/W2099766227, https://openalex.org/W2291703909, https://openalex.org/W1978146894, https://openalex.org/W1837960509, https://openalex.org/W1980950773, https://openalex.org/W2108872824, https://openalex.org/W1968822620, https://openalex.org/W1979518793, https://openalex.org/W2046469335, https://openalex.org/W157700276, https://openalex.org/W2623343525, https://openalex.org/W1997663906, https://openalex.org/W2125655548, https://openalex.org/W2178641192, https://openalex.org/W2027899709, https://openalex.org/W2010276018, https://openalex.org/W2411776721, https://openalex.org/W2961769471, https://openalex.org/W2122841055 |
| referenced_works_count | 104 |
| abstract_inverted_index.2 | 189 |
| abstract_inverted_index.I | 69, 113 |
| abstract_inverted_index.a | 48, 58, 75 |
| abstract_inverted_index.In | 98, 123 |
| abstract_inverted_index.To | 19 |
| abstract_inverted_index.We | 63, 152 |
| abstract_inverted_index.as | 74, 117, 194 |
| abstract_inverted_index.be | 169 |
| abstract_inverted_index.by | 38, 90, 133, 171 |
| abstract_inverted_index.in | 78, 106, 125, 144 |
| abstract_inverted_index.is | 6, 87, 131, 157 |
| abstract_inverted_index.of | 3, 47, 52, 102, 161, 166, 198 |
| abstract_inverted_index.or | 191 |
| abstract_inverted_index.to | 149, 179, 184 |
| abstract_inverted_index.we | 44 |
| abstract_inverted_index.BMP | 60, 67, 111, 199 |
| abstract_inverted_index.Dpp | 56, 76, 129, 140 |
| abstract_inverted_index.Sax | 156, 167, 185 |
| abstract_inverted_index.Sxc | 162 |
| abstract_inverted_index.Tkv | 135 |
| abstract_inverted_index.all | 32 |
| abstract_inverted_index.and | 15, 41, 136, 138, 163, 182 |
| abstract_inverted_index.are | 36 |
| abstract_inverted_index.but | 83 |
| abstract_inverted_index.can | 168 |
| abstract_inverted_index.for | 12, 16, 55, 121 |
| abstract_inverted_index.its | 85 |
| abstract_inverted_index.sex | 95 |
| abstract_inverted_index.sxc | 126 |
| abstract_inverted_index.the | 66, 79, 91, 107, 110, 118, 128, 158, 195 |
| abstract_inverted_index.Bone | 25 |
| abstract_inverted_index.Dpp. | 122 |
| abstract_inverted_index.Sax, | 137 |
| abstract_inverted_index.also | 153 |
| abstract_inverted_index.both | 11, 39, 134 |
| abstract_inverted_index.lead | 148 |
| abstract_inverted_index.like | 31 |
| abstract_inverted_index.link | 177 |
| abstract_inverted_index.sole | 119 |
| abstract_inverted_index.that | 65, 84, 147, 155, 164 |
| abstract_inverted_index.type | 68, 112 |
| abstract_inverted_index.(BMP) | 28 |
| abstract_inverted_index.(Sax) | 72, 104 |
| abstract_inverted_index.(Tkv) | 116 |
| abstract_inverted_index.Here, | 43 |
| abstract_inverted_index.Super | 94 |
| abstract_inverted_index.adult | 17 |
| abstract_inverted_index.combs | 96 |
| abstract_inverted_index.life, | 10 |
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| abstract_inverted_index.other | 33 |
| abstract_inverted_index.point | 183 |
| abstract_inverted_index.these | 175 |
| abstract_inverted_index.(Sxc). | 97 |
| abstract_inverted_index.ALK2]) | 192 |
| abstract_inverted_index.[ACVR1 | 190 |
| abstract_inverted_index.branch | 197 |
| abstract_inverted_index.death. | 151 |
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| abstract_inverted_index.target | 160 |
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| abstract_inverted_index.Summary | 0 |
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| abstract_inverted_index.dietary | 172 |
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| abstract_inverted_index.mutants, | 127 |
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| abstract_inverted_index.receptor | 70, 77, 114 |
| abstract_inverted_index.Graphical | 201 |
| abstract_inverted_index.Saxophone | 71, 103 |
| abstract_inverted_index.Together, | 174 |
| abstract_inverted_index.contrast, | 124 |
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| abstract_inverted_index.Drosophila | 59, 80 |
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| abstract_inverted_index.(Decapentaplegic), | 57 |
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| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
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| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.09153913 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |