Regulation of coordinated muscular relaxation by a pattern-generating intersegmental circuit Article Swipe

PDF

Atsuki Hiramoto , Julius Jonaitis , Sawako Niki , Hiroshi Kohsaka , Richard D. Fetter , Albert Cardona , Stefan R. Pulver , Akinao Nose ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1101/2021.03.08.434356

Typical patterned movements in animals are achieved through combinations of contraction and delayed relaxation of groups of muscles. However, how intersegmentally coordinated patterns of muscular relaxation are regulated by the neural circuits remain poorly understood. Here, we identify Canon, a class of higher-order premotor interneurons, that regulates muscular relaxation during backward locomotion of Drosophila larvae. Canon neurons are cholinergic interneurons present in each abdominal neuromere and show wave-like activity during fictive backward locomotion. Optogenetic activation of Canon neurons induces relaxation of body wall muscles, whereas inhibition of these neurons disrupts timely muscle relaxation. Canon neurons provide excitatory outputs to inhibitory premotor interneurons. Canon neurons also connect with each other to form an intersegmental circuit and regulate their own wave-like activities. Thus, our results demonstrate how coordinated muscle relaxation can be realized by an intersegmental circuit that regulates its own patterned activity and sequentially terminates motor activities along the anterior-posterior axis.

Related Topics

Neuroscience

Excitatory Postsynaptic Potential

Concepts

Optogenetics Neuroscience Inhibitory postsynaptic potential Cholinergic Excitatory postsynaptic potential Biological neural network Relaxation (psychology) Physics Chemistry Biology

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2021.03.08.434356
PDF: https://www.biorxiv.org/content/biorxiv/early/2021/03/08/2021.03.08.434356.full.pdf
OA Status: green
Cited By: 2
References: 59
Related Works: 10
OpenAlex ID: https://openalex.org/W3135818133

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W3135818133

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1101/2021.03.08.434356

Digital Object Identifier
Title: Regulation of coordinated muscular relaxation by a pattern-generating intersegmental circuit

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2021

Year of publication
Publication date: 2021-03-08

Full publication date if available
Authors: Atsuki Hiramoto, Julius Jonaitis, Sawako Niki, Hiroshi Kohsaka, Richard D. Fetter, Albert Cardona, Stefan R. Pulver, Akinao Nose

List of authors in order
Landing page: https://doi.org/10.1101/2021.03.08.434356

Publisher landing page
PDF URL: https://www.biorxiv.org/content/biorxiv/early/2021/03/08/2021.03.08.434356.full.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://www.biorxiv.org/content/biorxiv/early/2021/03/08/2021.03.08.434356.full.pdf

Direct OA link when available
Concepts: Optogenetics, Neuroscience, Inhibitory postsynaptic potential, Cholinergic, Excitatory postsynaptic potential, Biological neural network, Relaxation (psychology), Physics, Chemistry, Biology

Top concepts (fields/topics) attached by OpenAlex
Cited by: 2

Total citation count in OpenAlex
Citations by year (recent): 2022: 1, 2021: 1

Per-year citation counts (last 5 years)
References (count): 59

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W3135818133
doi	https://doi.org/10.1101/2021.03.08.434356
ids.doi	https://doi.org/10.1101/2021.03.08.434356
ids.mag	3135818133
ids.openalex	https://openalex.org/W3135818133
fwci	0.24263765
type	preprint
title	Regulation of coordinated muscular relaxation by a pattern-generating intersegmental circuit
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T10423
topics[0].field.id	https://openalex.org/fields/28
topics[0].field.display_name	Neuroscience
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/2804
topics[0].subfield.display_name	Cellular and Molecular Neuroscience
topics[0].display_name	Neurobiology and Insect Physiology Research
topics[1].id	https://openalex.org/T10342
topics[1].field.id	https://openalex.org/fields/28
topics[1].field.display_name	Neuroscience
topics[1].score	0.9994000196456909
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/2807
topics[1].subfield.display_name	Endocrine and Autonomic Systems
topics[1].display_name	Circadian rhythm and melatonin
topics[2].id	https://openalex.org/T12236
topics[2].field.id	https://openalex.org/fields/28
topics[2].field.display_name	Neuroscience
topics[2].score	0.9976999759674072
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/2804
topics[2].subfield.display_name	Cellular and Molecular Neuroscience
topics[2].display_name	Photoreceptor and optogenetics research
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C50738837
concepts[0].level	2
concepts[0].score	0.8053488731384277
concepts[0].wikidata	https://www.wikidata.org/wiki/Q781492
concepts[0].display_name	Optogenetics
concepts[1].id	https://openalex.org/C169760540
concepts[1].level	1
concepts[1].score	0.6472549438476562
concepts[1].wikidata	https://www.wikidata.org/wiki/Q207011
concepts[1].display_name	Neuroscience
concepts[2].id	https://openalex.org/C17077164
concepts[2].level	2
concepts[2].score	0.5689154863357544
concepts[2].wikidata	https://www.wikidata.org/wiki/Q1185869
concepts[2].display_name	Inhibitory postsynaptic potential
concepts[3].id	https://openalex.org/C22885893
concepts[3].level	2
concepts[3].score	0.5250365734100342
concepts[3].wikidata	https://www.wikidata.org/wiki/Q4862743
concepts[3].display_name	Cholinergic
concepts[4].id	https://openalex.org/C112592302
concepts[4].level	3
concepts[4].score	0.5250341892242432
concepts[4].wikidata	https://www.wikidata.org/wiki/Q1207387
concepts[4].display_name	Excitatory postsynaptic potential
concepts[5].id	https://openalex.org/C118403218
concepts[5].level	2
concepts[5].score	0.4719395041465759
concepts[5].wikidata	https://www.wikidata.org/wiki/Q43283
concepts[5].display_name	Biological neural network
concepts[6].id	https://openalex.org/C2776029896
concepts[6].level	2
concepts[6].score	0.45420947670936584
concepts[6].wikidata	https://www.wikidata.org/wiki/Q3935810
concepts[6].display_name	Relaxation (psychology)
concepts[7].id	https://openalex.org/C121332964
concepts[7].level	0
concepts[7].score	0.34715336561203003
concepts[7].wikidata	https://www.wikidata.org/wiki/Q413
concepts[7].display_name	Physics
concepts[8].id	https://openalex.org/C185592680
concepts[8].level	0
concepts[8].score	0.3416893482208252
concepts[8].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[8].display_name	Chemistry
concepts[9].id	https://openalex.org/C86803240
concepts[9].level	0
concepts[9].score	0.31915581226348877
concepts[9].wikidata	https://www.wikidata.org/wiki/Q420
concepts[9].display_name	Biology
keywords[0].id	https://openalex.org/keywords/optogenetics
keywords[0].score	0.8053488731384277
keywords[0].display_name	Optogenetics
keywords[1].id	https://openalex.org/keywords/neuroscience
keywords[1].score	0.6472549438476562
keywords[1].display_name	Neuroscience
keywords[2].id	https://openalex.org/keywords/inhibitory-postsynaptic-potential
keywords[2].score	0.5689154863357544
keywords[2].display_name	Inhibitory postsynaptic potential
keywords[3].id	https://openalex.org/keywords/cholinergic
keywords[3].score	0.5250365734100342
keywords[3].display_name	Cholinergic
keywords[4].id	https://openalex.org/keywords/excitatory-postsynaptic-potential
keywords[4].score	0.5250341892242432
keywords[4].display_name	Excitatory postsynaptic potential
keywords[5].id	https://openalex.org/keywords/biological-neural-network
keywords[5].score	0.4719395041465759
keywords[5].display_name	Biological neural network
keywords[6].id	https://openalex.org/keywords/relaxation
keywords[6].score	0.45420947670936584
keywords[6].display_name	Relaxation (psychology)
keywords[7].id	https://openalex.org/keywords/physics
keywords[7].score	0.34715336561203003
keywords[7].display_name	Physics
keywords[8].id	https://openalex.org/keywords/chemistry
keywords[8].score	0.3416893482208252
keywords[8].display_name	Chemistry
keywords[9].id	https://openalex.org/keywords/biology
keywords[9].score	0.31915581226348877
keywords[9].display_name	Biology
language	en
locations[0].id	doi:10.1101/2021.03.08.434356
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4306402567
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	False
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
locations[0].source.host_organization	https://openalex.org/I2750212522
locations[0].source.host_organization_name	Cold Spring Harbor Laboratory
locations[0].source.host_organization_lineage	https://openalex.org/I2750212522
locations[0].license
locations[0].pdf_url	https://www.biorxiv.org/content/biorxiv/early/2021/03/08/2021.03.08.434356.full.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1101/2021.03.08.434356
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5008547746
authorships[0].author.orcid	https://orcid.org/0000-0003-4005-927X
authorships[0].author.display_name	Atsuki Hiramoto
authorships[0].countries	JP
authorships[0].affiliations[0].institution_ids	https://openalex.org/I74801974
authorships[0].affiliations[0].raw_affiliation_string	Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, 5--5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan
authorships[0].institutions[0].id	https://openalex.org/I74801974
authorships[0].institutions[0].ror	https://ror.org/057zh3y96
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I74801974
authorships[0].institutions[0].country_code	JP
authorships[0].institutions[0].display_name	The University of Tokyo
authorships[0].author_position	first
authorships[0].raw_author_name	Atsuki Hiramoto
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, 5--5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan
authorships[1].author.id	https://openalex.org/A5051952739
authorships[1].author.orcid	https://orcid.org/0000-0002-1703-9396
authorships[1].author.display_name	Julius Jonaitis
authorships[1].countries	GB
authorships[1].affiliations[0].institution_ids	https://openalex.org/I16835326
authorships[1].affiliations[0].raw_affiliation_string	School of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, South Street, St Andrews, KY16 9JP, UK
authorships[1].institutions[0].id	https://openalex.org/I16835326
authorships[1].institutions[0].ror	https://ror.org/02wn5qz54
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I16835326
authorships[1].institutions[0].country_code	GB
authorships[1].institutions[0].display_name	University of St Andrews
authorships[1].author_position	middle
authorships[1].raw_author_name	Julius Jonaitis
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	School of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, South Street, St Andrews, KY16 9JP, UK
authorships[2].author.id	https://openalex.org/A5073839754
authorships[2].author.orcid
authorships[2].author.display_name	Sawako Niki
authorships[2].countries	JP
authorships[2].affiliations[0].institution_ids	https://openalex.org/I74801974
authorships[2].affiliations[0].raw_affiliation_string	Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 15-8904, Japan
authorships[2].affiliations[1].institution_ids	https://openalex.org/I74801974
authorships[2].affiliations[1].raw_affiliation_string	Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, 5--5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan
authorships[2].institutions[0].id	https://openalex.org/I74801974
authorships[2].institutions[0].ror	https://ror.org/057zh3y96
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I74801974
authorships[2].institutions[0].country_code	JP
authorships[2].institutions[0].display_name	The University of Tokyo
authorships[2].author_position	middle
authorships[2].raw_author_name	Sawako Niki
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, 5--5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 15-8904, Japan
authorships[3].author.id	https://openalex.org/A5089463605
authorships[3].author.orcid	https://orcid.org/0000-0003-1087-9680
authorships[3].author.display_name	Hiroshi Kohsaka
authorships[3].countries	JP
authorships[3].affiliations[0].institution_ids	https://openalex.org/I74801974
authorships[3].affiliations[0].raw_affiliation_string	Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, 5--5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan
authorships[3].institutions[0].id	https://openalex.org/I74801974
authorships[3].institutions[0].ror	https://ror.org/057zh3y96
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I74801974
authorships[3].institutions[0].country_code	JP
authorships[3].institutions[0].display_name	The University of Tokyo
authorships[3].author_position	middle
authorships[3].raw_author_name	Hiroshi Kohsaka
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, 5--5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan
authorships[4].author.id	https://openalex.org/A5018040690
authorships[4].author.orcid	https://orcid.org/0000-0002-1558-100X
authorships[4].author.display_name	Richard D. Fetter
authorships[4].countries	US
authorships[4].affiliations[0].institution_ids	https://openalex.org/I195573530
authorships[4].affiliations[0].raw_affiliation_string	HHMI Janelia Research Campus, Ashburn, VA 2017, USA
authorships[4].institutions[0].id	https://openalex.org/I195573530
authorships[4].institutions[0].ror	https://ror.org/013sk6x84
authorships[4].institutions[0].type	facility
authorships[4].institutions[0].lineage	https://openalex.org/I1344073410, https://openalex.org/I195573530
authorships[4].institutions[0].country_code	US
authorships[4].institutions[0].display_name	Janelia Research Campus
authorships[4].author_position	middle
authorships[4].raw_author_name	Richard Fetter
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	HHMI Janelia Research Campus, Ashburn, VA 2017, USA
authorships[5].author.id	https://openalex.org/A5042603640
authorships[5].author.orcid	https://orcid.org/0000-0003-4941-6536
authorships[5].author.display_name	Albert Cardona
authorships[5].countries	GB, US
authorships[5].affiliations[0].institution_ids	https://openalex.org/I195573530
authorships[5].affiliations[0].raw_affiliation_string	HHMI Janelia Research Campus, Ashburn, VA 2017, USA
authorships[5].affiliations[1].institution_ids	https://openalex.org/I241749
authorships[5].affiliations[1].raw_affiliation_string	Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK
authorships[5].institutions[0].id	https://openalex.org/I241749
authorships[5].institutions[0].ror	https://ror.org/013meh722
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I241749
authorships[5].institutions[0].country_code	GB
authorships[5].institutions[0].display_name	University of Cambridge
authorships[5].institutions[1].id	https://openalex.org/I195573530
authorships[5].institutions[1].ror	https://ror.org/013sk6x84
authorships[5].institutions[1].type	facility
authorships[5].institutions[1].lineage	https://openalex.org/I1344073410, https://openalex.org/I195573530
authorships[5].institutions[1].country_code	US
authorships[5].institutions[1].display_name	Janelia Research Campus
authorships[5].author_position	middle
authorships[5].raw_author_name	Albert Cardona
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK, HHMI Janelia Research Campus, Ashburn, VA 2017, USA
authorships[6].author.id	https://openalex.org/A5090090741
authorships[6].author.orcid	https://orcid.org/0000-0001-5170-7522
authorships[6].author.display_name	Stefan R. Pulver
authorships[6].countries	GB
authorships[6].affiliations[0].institution_ids	https://openalex.org/I16835326
authorships[6].affiliations[0].raw_affiliation_string	School of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, South Street, St Andrews, KY16 9JP, UK
authorships[6].institutions[0].id	https://openalex.org/I16835326
authorships[6].institutions[0].ror	https://ror.org/02wn5qz54
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I16835326
authorships[6].institutions[0].country_code	GB
authorships[6].institutions[0].display_name	University of St Andrews
authorships[6].author_position	middle
authorships[6].raw_author_name	Stefan Pulver
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	School of Psychology and Neuroscience, University of St Andrews, St Mary's Quad, South Street, St Andrews, KY16 9JP, UK
authorships[7].author.id	https://openalex.org/A5033107831
authorships[7].author.orcid	https://orcid.org/0000-0002-0526-2128
authorships[7].author.display_name	Akinao Nose
authorships[7].countries	JP
authorships[7].affiliations[0].institution_ids	https://openalex.org/I74801974
authorships[7].affiliations[0].raw_affiliation_string	Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, 5--5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan
authorships[7].affiliations[1].institution_ids	https://openalex.org/I74801974
authorships[7].affiliations[1].raw_affiliation_string	Department of Physics, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
authorships[7].institutions[0].id	https://openalex.org/I74801974
authorships[7].institutions[0].ror	https://ror.org/057zh3y96
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I74801974
authorships[7].institutions[0].country_code	JP
authorships[7].institutions[0].display_name	The University of Tokyo
authorships[7].author_position	last
authorships[7].raw_author_name	Akinao Nose
authorships[7].is_corresponding	True
authorships[7].raw_affiliation_strings	Department of Complexity Science and Engineering, Graduate School of Frontier Sciences, The University of Tokyo, 5--5 Kashiwanoha, Kashiwa, Chiba 277-856, Japan, Department of Physics, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.biorxiv.org/content/biorxiv/early/2021/03/08/2021.03.08.434356.full.pdf
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Regulation of coordinated muscular relaxation by a pattern-generating intersegmental circuit
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10423
primary_topic.field.id	https://openalex.org/fields/28
primary_topic.field.display_name	Neuroscience
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2804
primary_topic.subfield.display_name	Cellular and Molecular Neuroscience
primary_topic.display_name	Neurobiology and Insect Physiology Research
related_works	https://openalex.org/W2791883561, https://openalex.org/W2950596497, https://openalex.org/W2436760910, https://openalex.org/W4303432678, https://openalex.org/W2043066229, https://openalex.org/W2082329602, https://openalex.org/W2023878078, https://openalex.org/W2142526561, https://openalex.org/W2974163011, https://openalex.org/W2106951973
cited_by_count	2
counts_by_year[0].year	2022
counts_by_year[0].cited_by_count	1
counts_by_year[1].year	2021
counts_by_year[1].cited_by_count	1
locations_count	1
best_oa_location.id	doi:10.1101/2021.03.08.434356
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4306402567
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
best_oa_location.source.host_organization	https://openalex.org/I2750212522
best_oa_location.source.host_organization_name	Cold Spring Harbor Laboratory
best_oa_location.source.host_organization_lineage	https://openalex.org/I2750212522
best_oa_location.license
best_oa_location.pdf_url	https://www.biorxiv.org/content/biorxiv/early/2021/03/08/2021.03.08.434356.full.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1101/2021.03.08.434356
primary_location.id	doi:10.1101/2021.03.08.434356
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4306402567
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	False
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
primary_location.source.host_organization	https://openalex.org/I2750212522
primary_location.source.host_organization_name	Cold Spring Harbor Laboratory
primary_location.source.host_organization_lineage	https://openalex.org/I2750212522
primary_location.license
primary_location.pdf_url	https://www.biorxiv.org/content/biorxiv/early/2021/03/08/2021.03.08.434356.full.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1101/2021.03.08.434356
publication_date	2021-03-08
publication_year	2021
referenced_works	https://openalex.org/W2168071184, https://openalex.org/W1824021067, https://openalex.org/W1982508615, https://openalex.org/W2952571917, https://openalex.org/W2009452670, https://openalex.org/W2097869916, https://openalex.org/W2161093157, https://openalex.org/W2991847699, https://openalex.org/W2041330532, https://openalex.org/W2074716800, https://openalex.org/W2039207264, https://openalex.org/W2135445303, https://openalex.org/W2055435981, https://openalex.org/W2002015872, https://openalex.org/W2289996588, https://openalex.org/W2586994217, https://openalex.org/W2800560189, https://openalex.org/W2043210246, https://openalex.org/W2051077990, https://openalex.org/W2775091018, https://openalex.org/W2029648185, https://openalex.org/W2171884247, https://openalex.org/W2191239308, https://openalex.org/W2924530200, https://openalex.org/W2288271511, https://openalex.org/W2087543137, https://openalex.org/W2181199607, https://openalex.org/W2950585494, https://openalex.org/W1491075702, https://openalex.org/W1968358311, https://openalex.org/W2006805865, https://openalex.org/W2058082904, https://openalex.org/W2111531146, https://openalex.org/W1975012692, https://openalex.org/W2163314583, https://openalex.org/W2885496356, https://openalex.org/W2950681580, https://openalex.org/W1577451703, https://openalex.org/W2934064607, https://openalex.org/W2580319655, https://openalex.org/W2070083683, https://openalex.org/W4238183212, https://openalex.org/W2910271382, https://openalex.org/W1892652257, https://openalex.org/W2472629575, https://openalex.org/W1969271050, https://openalex.org/W2952067902, https://openalex.org/W2015832139, https://openalex.org/W2037183937, https://openalex.org/W2171332611, https://openalex.org/W1990943845, https://openalex.org/W2045387875, https://openalex.org/W2151381548, https://openalex.org/W2952402891, https://openalex.org/W2347019179, https://openalex.org/W2900563061, https://openalex.org/W2261263381, https://openalex.org/W3013824869, https://openalex.org/W1881455529
referenced_works_count	59
abstract_inverted_index.a	40
abstract_inverted_index.an	112, 133
abstract_inverted_index.be	130
abstract_inverted_index.by	29, 132
abstract_inverted_index.in	4, 62
abstract_inverted_index.of	10, 15, 17, 24, 42, 53, 76, 81, 87
abstract_inverted_index.to	99, 110
abstract_inverted_index.we	37
abstract_inverted_index.and	12, 66, 115, 142
abstract_inverted_index.are	6, 27, 58
abstract_inverted_index.can	129
abstract_inverted_index.how	20, 125
abstract_inverted_index.its	138
abstract_inverted_index.our	122
abstract_inverted_index.own	118, 139
abstract_inverted_index.the	30, 148
abstract_inverted_index.also	105
abstract_inverted_index.body	82
abstract_inverted_index.each	63, 108
abstract_inverted_index.form	111
abstract_inverted_index.show	67
abstract_inverted_index.that	46, 136
abstract_inverted_index.wall	83
abstract_inverted_index.with	107
abstract_inverted_index.Canon	56, 77, 94, 103
abstract_inverted_index.Here,	36
abstract_inverted_index.Thus,	121
abstract_inverted_index.along	147
abstract_inverted_index.axis.	150
abstract_inverted_index.class	41
abstract_inverted_index.motor	145
abstract_inverted_index.other	109
abstract_inverted_index.their	117
abstract_inverted_index.these	88
abstract_inverted_index.Canon,	39
abstract_inverted_index.during	50, 70
abstract_inverted_index.groups	16
abstract_inverted_index.muscle	92, 127
abstract_inverted_index.neural	31
abstract_inverted_index.poorly	34
abstract_inverted_index.remain	33
abstract_inverted_index.timely	91
abstract_inverted_index.Typical	1
abstract_inverted_index.animals	5
abstract_inverted_index.circuit	114, 135
abstract_inverted_index.connect	106
abstract_inverted_index.delayed	13
abstract_inverted_index.fictive	71
abstract_inverted_index.induces	79
abstract_inverted_index.larvae.	55
abstract_inverted_index.neurons	57, 78, 89, 95, 104
abstract_inverted_index.outputs	98
abstract_inverted_index.present	61
abstract_inverted_index.provide	96
abstract_inverted_index.results	123
abstract_inverted_index.through	8
abstract_inverted_index.whereas	85
abstract_inverted_index.Abstract	0
abstract_inverted_index.However,	19
abstract_inverted_index.achieved	7
abstract_inverted_index.activity	69, 141
abstract_inverted_index.backward	51, 72
abstract_inverted_index.circuits	32
abstract_inverted_index.disrupts	90
abstract_inverted_index.identify	38
abstract_inverted_index.muscles,	84
abstract_inverted_index.muscles.	18
abstract_inverted_index.muscular	25, 48
abstract_inverted_index.patterns	23
abstract_inverted_index.premotor	44, 101
abstract_inverted_index.realized	131
abstract_inverted_index.regulate	116
abstract_inverted_index.abdominal	64
abstract_inverted_index.movements	3
abstract_inverted_index.neuromere	65
abstract_inverted_index.patterned	2, 140
abstract_inverted_index.regulated	28
abstract_inverted_index.regulates	47, 137
abstract_inverted_index.wave-like	68, 119
abstract_inverted_index.Drosophila	54
abstract_inverted_index.activation	75
abstract_inverted_index.activities	146
abstract_inverted_index.excitatory	97
abstract_inverted_index.inhibition	86
abstract_inverted_index.inhibitory	100
abstract_inverted_index.locomotion	52
abstract_inverted_index.relaxation	14, 26, 49, 80, 128
abstract_inverted_index.terminates	144
abstract_inverted_index.Optogenetic	74
abstract_inverted_index.activities.	120
abstract_inverted_index.cholinergic	59
abstract_inverted_index.contraction	11
abstract_inverted_index.coordinated	22, 126
abstract_inverted_index.demonstrate	124
abstract_inverted_index.locomotion.	73
abstract_inverted_index.relaxation.	93
abstract_inverted_index.understood.	35
abstract_inverted_index.combinations	9
abstract_inverted_index.higher-order	43
abstract_inverted_index.interneurons	60
abstract_inverted_index.sequentially	143
abstract_inverted_index.interneurons,	45
abstract_inverted_index.interneurons.	102
abstract_inverted_index.intersegmental	113, 134
abstract_inverted_index.intersegmentally	21
abstract_inverted_index.anterior-posterior	149
cited_by_percentile_year.max	94
cited_by_percentile_year.min	89
corresponding_author_ids	https://openalex.org/A5033107831
countries_distinct_count	3
institutions_distinct_count	8
corresponding_institution_ids	https://openalex.org/I74801974
citation_normalized_percentile.value	0.45738178
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False