Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation. Article Swipe
Glenn Mortimore
,
Bernard Lardeux
,
Clay Adams
·
YOU?
·
· 1988
· Open Access
·
· DOI: https://doi.org/10.1016/s0021-9258(18)69235-x
YOU?
·
· 1988
· Open Access
·
· DOI: https://doi.org/10.1016/s0021-9258(18)69235-x
Basal rates of long-lived (resident) protein degradation in rat liver, measured during perfusion after amino acid suppression of macroautophagy, were shown to be strongly regulated by caloric deprivation, decreasing 70% over 48 h in animals fed a high protein diet and 50% in normal controls. Intralysosomal pools of degradable protein correlated directly with basal turnover over this range, yielding a slope (0.09 min-1) that was virtually identical with previous estimates of macroautophagic turnover. The specific radioactivity of valine released from lysosomes in previously labeled livers was the same as that in plasma in both basal and deprivation-induced states. Quantitative electron microscopy revealed a significant decrease with starvation in the absolute volume of a class of secondary lysosome (type A) previously associated with basal or microautophagy. By contrast, the volumes of other microautophagic forms, which comprised roughly 10% of the total, did not change. Taking 0.087 min-1 as the turnover constant of degradable intralysosomal protein and assuming that the concentration of sequestered protein was the same in all vacuoles as that in cytoplasm, we obtained close agreement between predicted and observed rates of basal protein turnover over the range of regulation. The results support the view that the lysosomal system is the final step in the basal degradation of long-lived proteins in the hepatocyte and that a specific class of secondary lysosome (type A) plays a direct role in its regulation during caloric starvation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/s0021-9258(18)69235-x
- OA Status
- hybrid
- Cited By
- 148
- References
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- OpenAlex ID
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All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W1507759123Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/s0021-9258(18)69235-xDigital Object Identifier
- Title
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Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation.Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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1988Year of publication
- Publication date
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1988-02-01Full publication date if available
- Authors
-
Glenn Mortimore, Bernard Lardeux, Clay AdamsList of authors in order
- Landing page
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https://doi.org/10.1016/s0021-9258(18)69235-xPublisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/s0021-9258(18)69235-xDirect OA link when available
- Concepts
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Starvation, Protein turnover, Term (time), Basal (medicine), Chemistry, Liver metabolism, Cell biology, Biochemistry, Internal medicine, Biology, Endocrinology, Protein biosynthesis, Medicine, Diabetes mellitus, Physics, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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148Total citation count in OpenAlex
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2025: 1, 2024: 3, 2023: 1, 2022: 5, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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39Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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