Regulation of the COPII secretory machinery via focal adhesions and extracellular matrix signaling Article Swipe
Juan E. Jung
,
Muzamil Majid Khan
,
Jonathan J. M. Landry
,
Aliaksandr Halavatyi
,
Pedro Machado
,
Miriam Reiss
,
Rainer Pepperkok
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1083/jcb.202110081
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1083/jcb.202110081
Proteins that enter the secretory pathway are transported from their place of synthesis in the endoplasmic reticulum to the Golgi complex by COPII-coated carriers. The networks of proteins that regulate these components in response to extracellular cues have remained largely elusive. Using high-throughput microscopy, we comprehensively screened 378 cytoskeleton-associated and related proteins for their functional interaction with the coat protein complex II (COPII) components SEC23A and SEC23B. Among these, we identified a group of proteins associated with focal adhesions (FERMT2, MACF1, MAPK8IP2, NGEF, PIK3CA, and ROCK1) that led to the downregulation of SEC23A when depleted by siRNA. Changes in focal adhesions induced by plating cells on ECM also led to the downregulation of SEC23A and decreases in VSVG transport from ER to Golgi. Both the expression of SEC23A and the transport defect could be rescued by treatment with a focal adhesion kinase inhibitor. Altogether, our results identify a network of cytoskeleton-associated proteins connecting focal adhesions and ECM-related signaling with the gene expression of the COPII secretory machinery and trafficking.
Related Topics
Concepts
COPII
Focal adhesion
Cell biology
Biology
Extracellular matrix
Golgi apparatus
Endoplasmic reticulum
Secretory pathway
Downregulation and upregulation
Actin cytoskeleton
Cytoskeleton
Signal transduction
Biochemistry
Cell
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1083/jcb.202110081
- OA Status
- hybrid
- Cited By
- 14
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285083523
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285083523Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1083/jcb.202110081Digital Object Identifier
- Title
-
Regulation of the COPII secretory machinery via focal adhesions and extracellular matrix signalingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-25Full publication date if available
- Authors
-
Juan E. Jung, Muzamil Majid Khan, Jonathan J. M. Landry, Aliaksandr Halavatyi, Pedro Machado, Miriam Reiss, Rainer PepperkokList of authors in order
- Landing page
-
https://doi.org/10.1083/jcb.202110081Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1083/jcb.202110081Direct OA link when available
- Concepts
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COPII, Focal adhesion, Cell biology, Biology, Extracellular matrix, Golgi apparatus, Endoplasmic reticulum, Secretory pathway, Downregulation and upregulation, Actin cytoskeleton, Cytoskeleton, Signal transduction, Biochemistry, Cell, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
14Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 3, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |