Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2 Article Swipe
Katelin E. Ahlers‐Dannen
,
Mohammed Alqinyah
,
Christopher Bodle
,
Josephine Bou Dagher
,
Bandana Chakravarti
,
Shreoshi Pal Choudhuri
,
Kirk M. Druey
,
Rory A. Fisher
,
Kyle J. Gerber
,
John R. Hepler
,
Shelley B. Hooks
,
Havish S. Kantheti
,
Behirda Karaj
,
Somayeh Layeghi‐Ghalehsoukhteh
,
Jae‐Kyung Lee
,
Zili Luo
,
Kirill A. Martemyanov
,
Luke D. Mascarenhas
,
Harrison J. McNabb
,
Carolina Montañez‐Miranda
,
Osita W. Ogujiofor
,
H. T. Phan
,
David L. Roman
,
Vincent Shaw
,
Benita Sjögren
,
Mackenzie M. Spicer
,
Katherine E. Squires
,
Laurie P. Sutton
,
Menbere Wendimu
,
Thomas M. Wilkie
,
Keqiang Xie
,
Qian Zhang
,
Yalda Zolghadri
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.2218/gtopdb/f891/2021.2
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.2218/gtopdb/f891/2021.2
Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins stabilize the transition state for GTP hydrolysis on Gα and thus induce a conformational change in the Gα subunit that accelerates GTP hydrolysis, thereby effectively turning off signaling cascades mediated by GPCRs. This GTPase accelerating protein (GAP) activity is the canonical mechanism of action for RGS proteins, although many also possess additional functions and domains. RGS proteins are divided into four families, R4, R7, R12 and RZ based on sequence homology, domain structure as well as specificity towards Gα subunits. For reviews on RGS proteins and their potential as therapeutic targets, see e.g. [225, 529, 578, 583, 584, 742, 753, 444, 10].
Related Topics
Concepts
Heterotrimeric G protein
GTPase-activating protein
RGS2
Regulator of G protein signaling
G protein
G protein-coupled receptor
GTPase
Cell biology
GTP-binding protein regulators
G beta-gamma complex
G alpha subunit
Chemistry
Gq alpha subunit
Protein subunit
Biology
Signal transduction
Biochemistry
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2218/gtopdb/f891/2021.2
- http://journals.ed.ac.uk/gtopdb-cite/article/download/5734/7598
- OA Status
- diamond
- Cited By
- 2
- References
- 556
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3177079023
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3177079023Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2218/gtopdb/f891/2021.2Digital Object Identifier
- Title
-
Regulators of G protein Signaling (RGS) proteins in GtoPdb v.2021.2Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-25Full publication date if available
- Authors
-
Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Christopher Bodle, Josephine Bou Dagher, Bandana Chakravarti, Shreoshi Pal Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill A. Martemyanov, Luke D. Mascarenhas, Harrison J. McNabb, Carolina Montañez‐Miranda, Osita W. Ogujiofor, H. T. Phan, David L. Roman, Vincent Shaw, Benita Sjögren, Mackenzie M. Spicer, Katherine E. Squires, Laurie P. Sutton, Menbere Wendimu, Thomas M. Wilkie, Keqiang Xie, Qian Zhang, Yalda ZolghadriList of authors in order
- Landing page
-
https://doi.org/10.2218/gtopdb/f891/2021.2Publisher landing page
- PDF URL
-
https://journals.ed.ac.uk/gtopdb-cite/article/download/5734/7598Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://journals.ed.ac.uk/gtopdb-cite/article/download/5734/7598Direct OA link when available
- Concepts
-
Heterotrimeric G protein, GTPase-activating protein, RGS2, Regulator of G protein signaling, G protein, G protein-coupled receptor, GTPase, Cell biology, GTP-binding protein regulators, G beta-gamma complex, G alpha subunit, Chemistry, Gq alpha subunit, Protein subunit, Biology, Signal transduction, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2Per-year citation counts (last 5 years)
- References (count)
-
556Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.R7, | 105 |
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