Relating conformation to function in integrin α ₅ β ₁ Article Swipe

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Yang Su , Wei Xia , Jing Li , Thomas Walz , Martin J. Humphries , Dietmar Vestweber , Carlos Cabañas , Chafen Lu , Timothy A. Springer ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1073/pnas.1605074113

Significance β 1 integrins form the largest and most diverse integrin subfamily, with 12 distinct αβ heterodimers. Together, the seven other integrin β-subunits form an equal number of 12 heterodimers. Despite speculation that different integrin subfamilies may differ in activation mechanism or conformation, we show that α 5 β 1 , similar to β 2 and β 3 integrins, can adopt the bent-closed, extended-closed, and extended-open overall global conformational states. We characterize nine function-perturbing antibodies for the subunit and domain they bind and the conformation they stabilize. Only the extended-open α 5 β 1 conformation mediates adhesion to fibronectin. Our results enable many cell biological studies on the 12 β 1 integrins to be interpreted in terms of the integrin conformational states on cell surfaces that are stabilized.

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Integrin Fibronectin Protein subunit Subfamily Integrin alpha M Integrin, beta 6 Cell biology Cell adhesion Adhesion Function (biology) Collagen receptor CD49c Chemistry Biology Biophysics Cell Biochemistry Extracellular matrix Organic chemistry Gene

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Type: article
Language: en
Landing Page: https://doi.org/10.1073/pnas.1605074113
PDF: https://www.pnas.org/content/pnas/113/27/E3872.full.pdf
OA Status: bronze
Cited By: 135
References: 46
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DOI: https://doi.org/10.1073/pnas.1605074113

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Title: Relating conformation to function in integrin α ₅ β ₁

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Language: en

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Publication year: 2016

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Publication date: 2016-06-17

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Authors: Yang Su, Wei Xia, Jing Li, Thomas Walz, Martin J. Humphries, Dietmar Vestweber, Carlos Cabañas, Chafen Lu, Timothy A. Springer

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Landing page: https://doi.org/10.1073/pnas.1605074113

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Concepts: Integrin, Fibronectin, Protein subunit, Subfamily, Integrin alpha M, Integrin, beta 6, Cell biology, Cell adhesion, Adhesion, Function (biology), Collagen receptor, CD49c, Chemistry, Biology, Biophysics, Cell, Biochemistry, Extracellular matrix, Organic chemistry, Gene

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Cited by: 135

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Relating conformation to function in integrin α 5 β 1 Article Swipe

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