Relation between systemic arteriosclerosis and choroidal blood flow in patients with acute coronary syndrome Article Swipe
Yasunari Ebuchi
,
Taiji Nagaoka
,
Kushiyama Akifumi
,
Daisuke Fukamachi
,
Riku Arai
,
Kojima Keisuke
,
Yuki Saito
,
Daisuke Kitano
,
Harumasa Yokota
,
Satoru Yamagami
,
Yasuo Okumura
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-25526-y
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-25526-y
Blood flow parameters in the optic nerve head are associated with systemic atherosclerosis, early renal dysfunction, and diastolic cardiac dysfunction in patients with acute coronary syndrome (ACS). This study aimed to investigate the relationship between choroidal blood flow parameters evaluated using laser speckle flowgraphy (LSFG) and systemic atherosclerosis, cardiac function, and coronary artery disease severity in patients with acute coronary syndrome. We evaluated 44 patients admitted to the coronary care unit of Nihon University Itabashi Hospital for ACS between April 2019 and September 2020. Laser speckle flowgraphy was used to measure the mean blur rate (MBR) in three regions; the optic disc, and the choroidal region 1 disc diameter from the disc choroid temporally and nasally. Significant correlations were observed between the choroid MBR and systemic parameters in patients with ACS, including brachial-ankle pulse-wave velocity ( r = 0.33, P = 0.029) and left ventricular diastolic diameter ( r = − 0.30, P = 0.045). The choroidal MBR in the nasal region was significantly lower in the multivessel disease group than in the single vessel disease group (6.6 ± 1.6 vs. 8.5 ± 2.6, P = 0.006). The choroidal MBR was associated with systemic atherosclerosis, left ventricular remodeling, and coronary artery disease severity in patients with ACS, suggesting that it could be a useful non-invasive comprehensive arteriosclerotic marker.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-025-25526-y
- https://www.nature.com/articles/s41598-025-25526-y.pdf
- OA Status
- gold
- References
- 30
- OpenAlex ID
- https://openalex.org/W7106576401
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106576401Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-025-25526-yDigital Object Identifier
- Title
-
Relation between systemic arteriosclerosis and choroidal blood flow in patients with acute coronary syndromeWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-11-24Full publication date if available
- Authors
-
Yasunari Ebuchi, Taiji Nagaoka, Kushiyama Akifumi, Daisuke Fukamachi, Riku Arai, Kojima Keisuke, Yuki Saito, Daisuke Kitano, Harumasa Yokota, Satoru Yamagami, Yasuo OkumuraList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-025-25526-yPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-025-25526-y.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41598-025-25526-y.pdfDirect OA link when available
- Concepts
-
Medicine, Cardiology, Internal medicine, Blood flow, Choroid, Coronary artery disease, Acute coronary syndrome, Diastole, Artery, Hemodynamics, Laser Doppler velocimetry, Coronary arteriosclerosis, Cardiac catheterization, Optic nerve, Central retinal artery, Vascular resistanceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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30Number of works referenced by this work
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