Relationship between difference in endotracheal tube cuff area and airway area with minimum cuff pressure for adequate airway sealing: a prospective observational study Article Swipe
Honglei Wu
,
Yue‐Hong Wu
,
Wang‐Qin Shen
,
Jiahai Shi
,
Yanghui Xu
,
Hongwu Shen
,
Lei Ding
,
Yan‐Ping Zhu
,
Meijuan Lan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-85355-x
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-025-85355-x
It is essential for clinicians to select the appropriate endotracheal tube to ensure effective airway management. However, an unmatched endotracheal tube cuff area to the airway area can lead to air or secretion leakage, even at the recommended cuff pressure of 20-30 cmH2O. The present multicenter prospective observational study aimed to determine the relationship between the difference in cuff area and airway area with the minimum cuff pressure to avoid airway leakage. Adult patients who underwent mechanical ventilation were assigned into three groups, with a minimum cuff pressure of < 20, 20-30, and > 30 cmH2O, respectively, in order to have adequate airway sealing. The primary outcome was the difference between the endotracheal tube cuff area and airway area (cuff-airway area difference) that was calculated for the three groups. A total of 284 patients were included, with the mean age of 65.19 (± 14.03) years old. There were 166, 63 and 55 patients who required a minimum cuff pressure of < 20, 20-30 and > 30 cmH2O, respectively. The mean cuff-airway area difference was 236.00 ± 85.26, 149.70 ± 48.34 and - 12.29 ± 113.0 mm2 in the < 20, 20-30, and > 30 cmH2O groups, respectively. In addition, the simple linear regression analysis revealed a negative linear relationship between the cuff-airway area difference and minimum cuff pressure (Y = -0.1266 × X + 46.50, F = 571.40, p < 0.001). It can be concluded that a significant number of patients require a cuff pressure out of the recommended range (< 20 or > 30 mmH2O) to have adequate airway sealing. Patients with a lower cuff-airway area difference require a higher minimum cuff pressure to seal the airway.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-025-85355-x
- OA Status
- gold
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407711397
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4407711397Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-025-85355-xDigital Object Identifier
- Title
-
Relationship between difference in endotracheal tube cuff area and airway area with minimum cuff pressure for adequate airway sealing: a prospective observational studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-02-18Full publication date if available
- Authors
-
Honglei Wu, Yue‐Hong Wu, Wang‐Qin Shen, Jiahai Shi, Yanghui Xu, Hongwu Shen, Lei Ding, Yan‐Ping Zhu, Meijuan LanList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-025-85355-xPublisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1038/s41598-025-85355-xDirect OA link when available
- Concepts
-
Cuff, Airway, Endotracheal tube, Medicine, Observational study, Tube (container), Anesthesia, Surgery, Intubation, Internal medicine, Materials science, Composite materialTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5047677683 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I4210158318 |
| citation_normalized_percentile.value | 0.10238667 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |