Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex Virus Article Swipe
Sharon Baum
,
Itai Atar
,
Dan Coster
,
Sara Dovrat
,
Michal Solomon
,
Eli Sprecher
,
Tal Zeeli
,
Aviv Barzilai
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.2340/actadv.v102.917
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.2340/actadv.v102.917
Pemphigus vulgaris is a rare autoimmune skin disease. Although herpes simplex virus has been associated with autoimmune diseases, evidence regarding its association with pemphigus vulgaris exacerbations is scarce. This retrospective cohort study aimed to characterize the epidemiological and clinical features of patients with pemphigus vulgaris who were herpes simplex-positive, compared with those who were herpes simplex-negative, during disease onset. Of 62 patients with pemphigus vulgaris who underwent PCR testing for herpes simplex virus, 25 (40.3%) were positive, with a mean age of 56.1 ± 15.5 years; 35.5% were male. The herpes-positive group had significantly elevated levels of C-reactive protein, Pemphigus Disease Activity Index score, and shorter time to relapse. The time to remission, number of exacerbations per year, and remission status were non-significantly elevated in the herpes-positive group. Thus, routine testing lesions from patients with pemphigus for herpes simplex virus should be performed. If positive, antiviral treatment should be initiated; and preventive antiviral treatment should be considered in severe cases.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2340/actadv.v102.917
- https://medicaljournalssweden.se/actadv/article/download/917/4101
- OA Status
- gold
- Cited By
- 10
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4225693615
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4225693615Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2340/actadv.v102.917Digital Object Identifier
- Title
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Relationship Between Pemphigus Vulgaris Severity and PCR-positive Herpes Simplex VirusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-04-08Full publication date if available
- Authors
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Sharon Baum, Itai Atar, Dan Coster, Sara Dovrat, Michal Solomon, Eli Sprecher, Tal Zeeli, Aviv BarzilaiList of authors in order
- Landing page
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https://doi.org/10.2340/actadv.v102.917Publisher landing page
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https://medicaljournalssweden.se/actadv/article/download/917/4101Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://medicaljournalssweden.se/actadv/article/download/917/4101Direct OA link when available
- Concepts
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Pemphigus vulgaris, Pemphigus, Herpes simplex virus, Medicine, Immunology, Disease, Epidemiology, Internal medicine, VirusTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
- Citations by year (recent)
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2024: 6, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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