Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritis Article Swipe
Nésrine Elloumi
,
R. Fakhfakh
,
Olfa Abida
,
Lobna Ayadi
,
S. Marzouk
,
H. Hachicha
,
M Fourati
,
Z. Bahloul
,
Mohamed Nabil Mhiri
,
K. Kammoun
,
Hatem Masmoudi
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1111/cei.13022
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1111/cei.13022
Summary Toll-like receptor (TLR) genetic polymorphisms may modify their expression causing inflammatory disorders and influencing both susceptibility and severity of lupus erythematosus. We aim to determine whether TLR-5 and TLR-9 gene polymorphisms are implicated in the susceptibility to systemic lupus erythematosus (SLE) and lupus nephritis (LN) and to evaluate their expressions and distributions in renal LN patients' biopsies. The frequencies of two SNP in the TLR-9 gene and one in the TLR-5 gene was examined in 106 SLE patients (among them 37 LN patients) and in 200 matched controls by polymerase chain reaction–restriction fragment-length polymorphisms (PCR–RFLP) analysis. TLR-9 and TLR-5 expressions were assessed by reverse transcription (RT)–PCR and immunohistochemistry carried on LN renal biopsies compared to healthy renal tissue. A significant genotypic and allelic association was revealed between TLR-9-rs352140 and both SLE and LN (P < 0·05). The TLR-9 transcript level was significantly higher in LN biopsies compared to control (P < 0·05). This increase was observed histochemically in the tubulointerstitial compartment. TLR-9 was detectable in LN glomeruli patients but not in normal control glomeruli. No allelic nor genotype association was found with TLR-5-rs5744168 in SLE. but the T allele and the TT genotype were raised significantly in the LN group (P < 0·05). A significant increase in TLR-5 gene expression in LN biopsies, which contrasted with normal kidneys (P < 0·05), was confirmed by an intense and diffuse staining for TLR-5 only in LN tubules (P < 0·05). Our data show that TLR-5 and TLR-9 are susceptible genes to LN and that their expression is dysregulated in LN patients' kidneys, supporting a role of these mediators in the pathogenesis of LN.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/cei.13022
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cei.13022
- OA Status
- bronze
- Cited By
- 38
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2765857895
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- OpenAlex ID
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https://openalex.org/W2765857895Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/cei.13022Digital Object Identifier
- Title
-
Relevant genetic polymorphisms and kidney expression of Toll-like receptor (TLR)-5 and TLR-9 in lupus nephritisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-08-01Full publication date if available
- Authors
-
Nésrine Elloumi, R. Fakhfakh, Olfa Abida, Lobna Ayadi, S. Marzouk, H. Hachicha, M Fourati, Z. Bahloul, Mohamed Nabil Mhiri, K. Kammoun, Hatem MasmoudiList of authors in order
- Landing page
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https://doi.org/10.1111/cei.13022Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cei.13022Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cei.13022Direct OA link when available
- Concepts
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Lupus nephritis, Genotype, Allele, Immunology, Nephritis, Toll-like receptor, Biology, Kidney, Gene, Pathology, Medicine, Innate immune system, Endocrinology, Immune system, Genetics, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
38Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 5, 2023: 7, 2022: 7, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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54Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W2023138787, https://openalex.org/W1999321827, https://openalex.org/W2036427666, https://openalex.org/W2041185490, https://openalex.org/W6676939465, https://openalex.org/W1988104967, https://openalex.org/W2416310626, https://openalex.org/W2132497375, https://openalex.org/W6682332981, https://openalex.org/W1982224693, https://openalex.org/W2004465286, https://openalex.org/W2119985244, https://openalex.org/W1546746061, https://openalex.org/W1975988748, https://openalex.org/W2148555790, https://openalex.org/W2154887345, https://openalex.org/W1984338572, https://openalex.org/W6674883744, https://openalex.org/W2134106169, https://openalex.org/W2143642734, https://openalex.org/W2154280240, https://openalex.org/W2162154761, https://openalex.org/W1905977298, https://openalex.org/W2074290635, https://openalex.org/W2144309235, https://openalex.org/W1519633296, https://openalex.org/W2001921163, https://openalex.org/W2089877898, https://openalex.org/W2070527591, https://openalex.org/W2111940985, https://openalex.org/W2030447006, https://openalex.org/W2099371883, https://openalex.org/W6606102178, https://openalex.org/W1994496207, https://openalex.org/W2108196440, https://openalex.org/W2116339069, https://openalex.org/W2095927374, https://openalex.org/W2265000059, https://openalex.org/W2057872394, https://openalex.org/W2110926522, https://openalex.org/W2313854867, https://openalex.org/W6716395410, https://openalex.org/W2010802065, https://openalex.org/W2039820433, https://openalex.org/W1606251248, https://openalex.org/W6693278353, https://openalex.org/W6632686904, https://openalex.org/W2043263210, https://openalex.org/W2107674270, https://openalex.org/W2149641211, https://openalex.org/W2032484538, https://openalex.org/W2090590136, https://openalex.org/W150114464, https://openalex.org/W2511456449 |
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