Remotely Controlled Proton Generation for Neuromodulation Article Swipe
Jimin Park
,
Anthony Tabet
,
Junsang Moon
,
Po‐Han Chiang
,
Florian Koehler
,
Atharva Sahasrabudhe
,
Polina Anikeeva
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv.12369893
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.26434/chemrxiv.12369893
Understanding and modulating proton-mediated biochemical processes in living organisms have been impeded by the lack of tools to control local pH. Here, we design nanotransducers capable of converting non-invasive alternating magnetic fields (AMFs) into protons in physiological environments by combining magnetic nanoparticles (MNPs) with polymeric scaffolds. When exposed to AMFs, the heat dissipated by MNPs triggered a hydrolytic degradation of surrounding polyanhydride or polyester, releasing protons into the extracellular space. pH changes induced by these nanotransducers can be tuned by changing the polymer chemistry or AMF stimulation parameters. Remote magnetic control of local protons was shown to trigger acid-sensing ion channels and evoke intracellular calcium influx in neurons. By offering a wireless modulation of local pH, our approach can accelerate the mechanistic investigation of the role of protons in biochemical signalling in the nervous system.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.26434/chemrxiv.12369893
- OA Status
- gold
- Cited By
- 1
- References
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4249886104Canonical identifier for this work in OpenAlex
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https://doi.org/10.26434/chemrxiv.12369893Digital Object Identifier
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Remotely Controlled Proton Generation for NeuromodulationWork title
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preprintOpenAlex work type
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enPrimary language
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2020Year of publication
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2020-05-27Full publication date if available
- Authors
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Jimin Park, Anthony Tabet, Junsang Moon, Po‐Han Chiang, Florian Koehler, Atharva Sahasrabudhe, Polina AnikeevaList of authors in order
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https://doi.org/10.26434/chemrxiv.12369893Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.26434/chemrxiv.12369893Direct OA link when available
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Neuromodulation, Proton, Extracellular, Biophysics, Chemistry, Intracellular, Degradation (telecommunications), Polymer, Nanotechnology, Materials science, Biochemistry, Computer science, Physics, Biology, Organic chemistry, Quantum mechanics, Telecommunications, ReceptorTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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