Repair of Critical‐Sized Long Bone Defects Using Dipyridamole‐Augmented 3D‐Printed Bioactive Ceramic Scaffolds Article Swipe
Lukasz Witek
,
Adham M. Alifarag
,
Nick Tovar
,
Christopher D. Lopez
,
Bruce N. Cronstein
,
Eduardo D. Rodriguez
,
Paulo G. Coelho
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/jor.24424
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/jor.24424
There are over two million long bone defects treated in the United States annually, of which ~5% will not heal without significant surgical intervention. While autogenous grafting is the standard of care in simple defects, a customized scaffold for large defects in unlimited quantities is not available. Recently, a three‐dimensionally (3D)‐printed bioactive ceramic (3DPBC) scaffold has been successfully utilized in the of repair critical‐sized (CSD) long bone defects in vivo. In this study, 3DPBC scaffolds were augmented with dipyridamole (DIPY), an adenosine A2A receptor (A 2A R) indirect agonist, because of its known effect to enhance bone formation. CSD full thickness segmental defects (~11 mm × full thickness) defects were created in the radial diaphysis in New Zealand white rabbits ( n = 24). A customized 3DPBC scaffold composed of β‐tricalcium phosphate was placed into the defect site. Groups included scaffolds that were collagen‐coated (COLL), or immersed in 10, 100, or 1,000 μM DIPY solution. Animals were euthanized 8 weeks post‐operatively and the radii/ulna‐scaffold complex retrieved en bloc, for micro‐CT, histological, and mechanical analysis. Bone growth was assessed exclusively within scaffold pores and evaluated by microCT and advanced reconstruction software. Biomechanical properties were evaluated utilizing nanoindentation to assess the newly regenerated bone for elastic modulus ( E ) and hardness ( H ). MicroCT reconstructions illustrated bone in‐growth throughout the scaffold, with an increase in bone volume dependent on the DIPY dosage. The histological evaluation did not indicate any adverse immune response while revealing progressive remodeling of bone. These customized biologic 3DPBC scaffolds have the potential of repairing and regenerating bone. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2499–2507, 2019
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jor.24424
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24424
- OA Status
- bronze
- Cited By
- 50
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2963953143
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2963953143Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/jor.24424Digital Object Identifier
- Title
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Repair of Critical‐Sized Long Bone Defects Using Dipyridamole‐Augmented 3D‐Printed Bioactive Ceramic ScaffoldsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
-
2019-07-23Full publication date if available
- Authors
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Lukasz Witek, Adham M. Alifarag, Nick Tovar, Christopher D. Lopez, Bruce N. Cronstein, Eduardo D. Rodriguez, Paulo G. CoelhoList of authors in order
- Landing page
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https://doi.org/10.1002/jor.24424Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24424Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jor.24424Direct OA link when available
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3d printed, Dipyridamole, Materials science, Ceramic, 3D printing, Biomedical engineering, Composite material, Dentistry, Medicine, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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50Total citation count in OpenAlex
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2025: 3, 2024: 15, 2023: 13, 2022: 6, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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49Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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