Repetitive extragenic palindromic DNA sequences from Brucella melitensis stimulate Toll-like receptor 9 signaling in macrophages Article Swipe
Hui Yu
,
Liyun Bai
,
Yaxian Zhang
,
Zhanli Wang
,
Yongchun Yu
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3892/mmr.2016.5990
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.3892/mmr.2016.5990
Brucella DNA activates the host innate immune system via the intracellular Toll-like receptor 9 (TLR9). However, the Brucella DNA sequences which are responsible for these immunostimulatory effects remain to be elucidated. The present study demonstrated that repetitive extragenic palindromic (REPs) sequences present in Brucella DNA were able to stimulate macrophages through TLR9. The induction of interferon-α (IFN-α) production by Brucella REPs was detected in cultured RAW264.7 mouse macrophages as well as in Wistar rats. Knockdown of TLR9 expression by siRNA in macrophages led to a reduction in IFN-α production following REPs stimulation. In addition, it was confirmed that the activating capacity of Brucella REPs is CpG dependent. Induction of IFN-α by Brucella REPs was completely abrogated when REP sequences were transformed into non-CpG sequences or by C-methylated modifications. Furthermore, it was observed that REPs-initiated TLR9/NF-κB and TLR9/MAPK signaling pathways contributed to the production of IFN-α. The identification of Brucella REPs as natural TLR9 agonists may be useful for the development of novel therapeutic applications.
Related Topics
Concepts
TLR9
Brucella
Toll-Like Receptor 9
Biology
Brucella melitensis
Innate immune system
Gene knockdown
CpG site
Cell biology
Immune system
Microbiology
Immunology
Gene
Genetics
Gene expression
DNA methylation
Brucellosis
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/mmr.2016.5990
- http://www.spandidos-publications.com/10.3892/mmr.2016.5990/download
- OA Status
- bronze
- Cited By
- 1
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2559901556
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2559901556Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/mmr.2016.5990Digital Object Identifier
- Title
-
Repetitive extragenic palindromic DNA sequences from Brucella melitensis stimulate Toll-like receptor 9 signaling in macrophagesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-12-06Full publication date if available
- Authors
-
Hui Yu, Liyun Bai, Yaxian Zhang, Zhanli Wang, Yongchun YuList of authors in order
- Landing page
-
https://doi.org/10.3892/mmr.2016.5990Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/mmr.2016.5990/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.spandidos-publications.com/10.3892/mmr.2016.5990/downloadDirect OA link when available
- Concepts
-
TLR9, Brucella, Toll-Like Receptor 9, Biology, Brucella melitensis, Innate immune system, Gene knockdown, CpG site, Cell biology, Immune system, Microbiology, Immunology, Gene, Genetics, Gene expression, DNA methylation, BrucellosisTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 1Per-year citation counts (last 5 years)
- References (count)
-
19Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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