Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneity Article Swipe
Marija Markicevic
,
Francesca Mandino
,
Takuya Toyonaga
,
Zhengxin Cai
,
Arman Fesharaki‐Zadeh
,
Xilin Shen
,
Stephen M. Strittmatter
,
Evelyn Lake
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.05.24.595651
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.05.24.595651
Repeated mild head injuries due to sports, or domestic violence and military service are increasingly linked to debilitating symptoms in the long term. Although symptoms may take decades to manifest, potentially treatable neurobiological alterations must begin shortly after injury. Better means to diagnose and treat traumatic brain injuries, requires an improved understanding of the mechanisms underlying progression and means through which they can be measured. Here, we employ a repetitive mild closed-head injury (rmTBI) and chronic variable stress (CVS) mouse model to investigate emergent structural and functional brain abnormalities. Brain imaging is achieved with [ 18 F]SynVesT-1 positron emission tomography, with the synaptic vesicle glycoprotein 2A ligand marking synapse density and BOLD (blood-oxygen-level-dependent) functional magnetic resonance imaging (fMRI). Animals were scanned six weeks after concluding rmTBI/Stress procedures. Injured mice showed widespread decreases in synaptic density coupled with an i ncrease in local BOLD-fMRI synchrony detected as regional homogeneity. Injury-affected regions with higher synapse density showed a greater increase in fMRI regional homogeneity. Taken together, these observations may reflect compensatory mechanisms following injury. Multimodal studies are needed to provide deeper insights into these observations.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.05.24.595651
- OA Status
- green
- References
- 93
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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- DOI
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https://doi.org/10.1101/2024.05.24.595651Digital Object Identifier
- Title
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Repetitive mild closed-head injury induced synapse loss and increased local BOLD-fMRI signal homogeneityWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-27Full publication date if available
- Authors
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Marija Markicevic, Francesca Mandino, Takuya Toyonaga, Zhengxin Cai, Arman Fesharaki‐Zadeh, Xilin Shen, Stephen M. Strittmatter, Evelyn LakeList of authors in order
- Landing page
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https://doi.org/10.1101/2024.05.24.595651Publisher landing page
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/11142233Direct OA link when available
- Concepts
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Homogeneity (statistics), Neuroscience, Synapse, Psychology, Physical medicine and rehabilitation, Medicine, Computer science, Machine learningTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| publication_date | 2024-05-27 |
| publication_year | 2024 |
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