Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell culture Article Swipe
Simona Serratì
,
Chiara Martinelli
,
Antonio J. Palazzo
,
Rosa Maria Iacobazzi
,
Mara Perrone
,
Quy K. Ong
,
Zhi Luo
,
Ahmet Bekdemir
,
Giulia Pinto
,
Ornella Cavalleri
,
Annalisa Cutrignelli
,
Valentino Laquintana
,
Nunzio Denora
,
Francesco Stellacci
,
Silke Krol
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0224002
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0224002
Reproducibility of results is essential for a well-designed and conducted experiment. Several reasons may originate failure in reproducing data, such as selective reporting, low statistical power, or poor analysis. In this study, we used PEG6000 samples from different distributors and tested their capability inducing spheroid formation upon surface coating. MALDI-MS, NMR, FTIR, and Triple SEC analysis of the different PEG60000s showed nearly identical physicochemical properties different, with only minor differences in mass and hydrodynamic radius, and AFM analysis showed no significant differences in the surface coatings obtained with the available PEG6000s. Despite these similarities, just one showed a highly reproducible formation of spheroids with different cell lines, such as HT-29, HeLa, Caco2, and PANC-1. Using the peculiar PEG6000 sample and a reference PEG6000 chosen amongst the others as control, we tested the effect of the cell/PEG interaction by incubating cells in the PEG solution prior to cell plating. These experiments indicate that the spheroid formation is due to direct interaction of the polymer with the cells rather than by interaction of cells with the coated surfaces. The experiments point out that for biological entities, such as cells or tissues, even very small differences in impurities or minimal variations in the starting product can have a very strong impact on the reproducibility of data.
Related Topics
Concepts
Spheroid
Reproducibility
PEG ratio
Polyethylene glycol
Polymer
Coating
HeLa
Materials science
Chemistry
Analytical Chemistry (journal)
Biophysics
Biomedical engineering
Chemical engineering
Nanotechnology
Cell
Chromatography
In vitro
Biology
Biochemistry
Composite material
Finance
Engineering
Economics
Medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0224002
- https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0224002&type=printable
- OA Status
- gold
- Cited By
- 7
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3011577531
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3011577531Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1371/journal.pone.0224002Digital Object Identifier
- Title
-
Reproducibility warning: The curious case of polyethylene glycol 6000 and spheroid cell cultureWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-03-19Full publication date if available
- Authors
-
Simona Serratì, Chiara Martinelli, Antonio J. Palazzo, Rosa Maria Iacobazzi, Mara Perrone, Quy K. Ong, Zhi Luo, Ahmet Bekdemir, Giulia Pinto, Ornella Cavalleri, Annalisa Cutrignelli, Valentino Laquintana, Nunzio Denora, Francesco Stellacci, Silke KrolList of authors in order
- Landing page
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https://doi.org/10.1371/journal.pone.0224002Publisher landing page
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0224002&type=printableDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0224002&type=printableDirect OA link when available
- Concepts
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Spheroid, Reproducibility, PEG ratio, Polyethylene glycol, Polymer, Coating, HeLa, Materials science, Chemistry, Analytical Chemistry (journal), Biophysics, Biomedical engineering, Chemical engineering, Nanotechnology, Cell, Chromatography, In vitro, Biology, Biochemistry, Composite material, Finance, Engineering, Economics, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 3, 2021: 3Per-year citation counts (last 5 years)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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