Repulsive interactions instruct synaptic partner matching in an olfactory circuit Article Swipe
Zhuoran Li
,
Cheng Lyu
,
Chuanyun Xu
,
Ying Hu
,
David J. Luginbuhl
,
Asaf B. Caspi-Lebovic
,
James E. Priest
,
Engin Özkan
,
Liqun Luo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.03.01.640985
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1101/2025.03.01.640985
Neurons exhibit extraordinary precision in selecting synaptic partners. Although cell-surface proteins (CSPs) mediating attractive interactions between developing axons and dendrites have been shown to instruct synaptic partner matching 1,2 , the degree to which repulsive interactions play a role is less clear. Here, using a genetic screen guided by single-cell transcriptomes 3,4 , we identified three CSP pairs—Toll2–Ptp10D, Fili–Kek1, and Hbs/Sns– Kirre—in mediating repulsive interactions between non-partner olfactory receptor neuron (ORN) axons and projection neuron (PN) dendrites in the developing Drosophila olfactory circuit. Each CSP pair exhibits inverse expression patterns in the select ORN-PN partners. Loss of each CSP in ORNs led to similar synaptic partner matching deficits as the loss of its partner CSP in PNs, and mistargeting phenotypes caused by overexpressing one CSP could be suppressed by loss of its partner CSP. All CSP pairs are also differentially expressed in other brain regions. Together, our data reveal that multiple repulsive CSP pairs work together to ensure precise synaptic partner matching during development by preventing neurons from forming connections with non-cognate partners.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2025.03.01.640985
- https://www.biorxiv.org/content/biorxiv/early/2025/03/02/2025.03.01.640985.full.pdf
- OA Status
- green
- Cited By
- 4
- References
- 83
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408084786
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Raw OpenAlex JSON
- OpenAlex ID
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- DOI
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https://doi.org/10.1101/2025.03.01.640985Digital Object Identifier
- Title
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Repulsive interactions instruct synaptic partner matching in an olfactory circuitWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-03-02Full publication date if available
- Authors
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Zhuoran Li, Cheng Lyu, Chuanyun Xu, Ying Hu, David J. Luginbuhl, Asaf B. Caspi-Lebovic, James E. Priest, Engin Özkan, Liqun LuoList of authors in order
- Landing page
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https://doi.org/10.1101/2025.03.01.640985Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2025/03/02/2025.03.01.640985.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2025/03/02/2025.03.01.640985.full.pdfDirect OA link when available
- Concepts
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Neuroscience, Matching (statistics), Olfactory system, Computer science, Psychology, Medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 4Per-year citation counts (last 5 years)
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83Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2025.03.01.640985 |
| primary_location.id | doi:10.1101/2025.03.01.640985 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2025/03/02/2025.03.01.640985.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2025.03.01.640985 |
| publication_date | 2025-03-02 |
| publication_year | 2025 |
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| referenced_works_count | 83 |
| abstract_inverted_index., | 30, 53 |
| abstract_inverted_index.a | 38, 45 |
| abstract_inverted_index.as | 109 |
| abstract_inverted_index.be | 127 |
| abstract_inverted_index.by | 49, 122, 129, 165 |
| abstract_inverted_index.in | 5, 78, 91, 100, 116, 142 |
| abstract_inverted_index.is | 40 |
| abstract_inverted_index.of | 97, 112, 131 |
| abstract_inverted_index.to | 24, 33, 103, 157 |
| abstract_inverted_index.we | 54 |
| abstract_inverted_index.1,2 | 29 |
| abstract_inverted_index.3,4 | 52 |
| abstract_inverted_index.All | 135 |
| abstract_inverted_index.CSP | 57, 85, 99, 115, 125, 136, 153 |
| abstract_inverted_index.and | 19, 60, 73, 118 |
| abstract_inverted_index.are | 138 |
| abstract_inverted_index.its | 113, 132 |
| abstract_inverted_index.led | 102 |
| abstract_inverted_index.one | 124 |
| abstract_inverted_index.our | 147 |
| abstract_inverted_index.the | 31, 79, 92, 110 |
| abstract_inverted_index.(PN) | 76 |
| abstract_inverted_index.CSP. | 134 |
| abstract_inverted_index.Each | 84 |
| abstract_inverted_index.Loss | 96 |
| abstract_inverted_index.ORNs | 101 |
| abstract_inverted_index.PNs, | 117 |
| abstract_inverted_index.also | 139 |
| abstract_inverted_index.been | 22 |
| abstract_inverted_index.data | 148 |
| abstract_inverted_index.each | 98 |
| abstract_inverted_index.from | 168 |
| abstract_inverted_index.have | 21 |
| abstract_inverted_index.less | 41 |
| abstract_inverted_index.loss | 111, 130 |
| abstract_inverted_index.pair | 86 |
| abstract_inverted_index.play | 37 |
| abstract_inverted_index.role | 39 |
| abstract_inverted_index.that | 150 |
| abstract_inverted_index.with | 171 |
| abstract_inverted_index.work | 155 |
| abstract_inverted_index.(ORN) | 71 |
| abstract_inverted_index.Here, | 43 |
| abstract_inverted_index.axons | 18, 72 |
| abstract_inverted_index.brain | 144 |
| abstract_inverted_index.could | 126 |
| abstract_inverted_index.other | 143 |
| abstract_inverted_index.pairs | 137, 154 |
| abstract_inverted_index.shown | 23 |
| abstract_inverted_index.three | 56 |
| abstract_inverted_index.using | 44 |
| abstract_inverted_index.which | 34 |
| abstract_inverted_index.(CSPs) | 12 |
| abstract_inverted_index.ORN-PN | 94 |
| abstract_inverted_index.caused | 121 |
| abstract_inverted_index.clear. | 42 |
| abstract_inverted_index.degree | 32 |
| abstract_inverted_index.during | 163 |
| abstract_inverted_index.ensure | 158 |
| abstract_inverted_index.guided | 48 |
| abstract_inverted_index.neuron | 70, 75 |
| abstract_inverted_index.reveal | 149 |
| abstract_inverted_index.screen | 47 |
| abstract_inverted_index.select | 93 |
| abstract_inverted_index.Neurons | 1 |
| abstract_inverted_index.between | 16, 66 |
| abstract_inverted_index.exhibit | 2 |
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| abstract_inverted_index.genetic | 46 |
| abstract_inverted_index.inverse | 88 |
| abstract_inverted_index.neurons | 167 |
| abstract_inverted_index.partner | 27, 106, 114, 133, 161 |
| abstract_inverted_index.precise | 159 |
| abstract_inverted_index.similar | 104 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Although | 9 |
| abstract_inverted_index.circuit. | 83 |
| abstract_inverted_index.deficits | 108 |
| abstract_inverted_index.exhibits | 87 |
| abstract_inverted_index.instruct | 25 |
| abstract_inverted_index.matching | 28, 107, 162 |
| abstract_inverted_index.multiple | 151 |
| abstract_inverted_index.patterns | 90 |
| abstract_inverted_index.proteins | 11 |
| abstract_inverted_index.receptor | 69 |
| abstract_inverted_index.regions. | 145 |
| abstract_inverted_index.synaptic | 7, 26, 105, 160 |
| abstract_inverted_index.together | 156 |
| abstract_inverted_index.Together, | 146 |
| abstract_inverted_index.dendrites | 20, 77 |
| abstract_inverted_index.expressed | 141 |
| abstract_inverted_index.mediating | 13, 63 |
| abstract_inverted_index.olfactory | 68, 82 |
| abstract_inverted_index.partners. | 8, 95, 173 |
| abstract_inverted_index.precision | 4 |
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| abstract_inverted_index.selecting | 6 |
| abstract_inverted_index.Drosophila | 81 |
| abstract_inverted_index.Hbs/Sns– | 61 |
| abstract_inverted_index.Kirre—in | 62 |
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| abstract_inverted_index.developing | 17, 80 |
| abstract_inverted_index.expression | 89 |
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| abstract_inverted_index.single-cell | 50 |
| abstract_inverted_index.Fili–Kek1, | 59 |
| abstract_inverted_index.cell-surface | 10 |
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| abstract_inverted_index.transcriptomes | 51 |
| abstract_inverted_index.pairs—Toll2–Ptp10D, | 58 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5019791073 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I1344073410 |
| citation_normalized_percentile.value | 0.9773022 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |