Repurposing of Berbamine Hydrochloride to Inhibit Ebola Virus by Targeting Viral Glycoprotein Article Swipe
Shan Cen
,
Dongrong Yi
,
Quanjie Li
,
Xiangguo Qiu
,
Han Wang
,
Zhenlong Liu
,
Shihua He
,
Wenjun Zhu
,
Kai Lv
,
Xiangyang Chi
,
Ling Ma
,
Yujia Wang
,
Jing Wang
,
Yongxin Zhang
,
Cong Zeng
,
Mingliang Liu
,
Shanlv Liu
,
Chen Liang
,
Xiaoyu Li
,
Logan Banadyga
,
Yi Shi
,
George F. Gao
,
Rongtuan Lin
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-111854/v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-111854/v1
Ebola virus (EBOV) infection leads to staggeringly high mortality rates. Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa. In this study, we report that a natural compound called berbamine hydrochloride strongly inhibits EBOV replication in vitro and in vivo. Our work further showed that berbamine hydrochloride acts by direct binding to the cleaved EBOV glycoprotein (GPcl), disrupting GPcl interaction with viral receptor NPC1, thus blocking the fusion of viral and cellular membranes. Our data support the probability of developing anti-EBOV small molecule drugs by targeting viral GPcl. More importantly, since berbamine hydrochloride has been used in clinic to treat leukopenia, it holds great promise of being quickly repurposed as an anti-EBOV drug.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-111854/v1
- https://www.researchsquare.com/article/rs-111854/v1.pdf?c=1606960441000
- OA Status
- green
- Cited By
- 1
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3125573301
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3125573301Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-111854/v1Digital Object Identifier
- Title
-
Repurposing of Berbamine Hydrochloride to Inhibit Ebola Virus by Targeting Viral GlycoproteinWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-12-02Full publication date if available
- Authors
-
Shan Cen, Dongrong Yi, Quanjie Li, Xiangguo Qiu, Han Wang, Zhenlong Liu, Shihua He, Wenjun Zhu, Kai Lv, Xiangyang Chi, Ling Ma, Yujia Wang, Jing Wang, Yongxin Zhang, Cong Zeng, Mingliang Liu, Shanlv Liu, Chen Liang, Xiaoyu Li, Logan Banadyga, Yi Shi, George F. Gao, Rongtuan LinList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-111854/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-111854/v1.pdf?c=1606960441000Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-111854/v1.pdf?c=1606960441000Direct OA link when available
- Concepts
-
Ebola virus, Repurposing, Virology, Glycoprotein, Ebolavirus, Virus, Chemistry, Biology, Biochemistry, EcologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2023: 1Per-year citation counts (last 5 years)
- References (count)
-
35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3125573301 |
|---|---|
| doi | https://doi.org/10.21203/rs.3.rs-111854/v1 |
| ids.doi | https://doi.org/10.21203/rs.3.rs-111854/v1 |
| ids.mag | 3125573301 |
| ids.openalex | https://openalex.org/W3125573301 |
| fwci | 0.02868689 |
| type | preprint |
| title | Repurposing of Berbamine Hydrochloride to Inhibit Ebola Virus by Targeting Viral Glycoprotein |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11581 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | Viral Infections and Outbreaks Research |
| topics[1].id | https://openalex.org/T10976 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9818999767303467 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | Viral gastroenteritis research and epidemiology |
| topics[2].id | https://openalex.org/T10118 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.980400025844574 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2725 |
| topics[2].subfield.display_name | Infectious Diseases |
| topics[2].display_name | SARS-CoV-2 and COVID-19 Research |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2777469322 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8694330453872681 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q8064876 |
| concepts[0].display_name | Ebola virus |
| concepts[1].id | https://openalex.org/C519536355 |
| concepts[1].level | 2 |
| concepts[1].score | 0.8428542017936707 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q21021151 |
| concepts[1].display_name | Repurposing |
| concepts[2].id | https://openalex.org/C159047783 |
| concepts[2].level | 1 |
| concepts[2].score | 0.6910676956176758 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[2].display_name | Virology |
| concepts[3].id | https://openalex.org/C108625454 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5198929309844971 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q187126 |
| concepts[3].display_name | Glycoprotein |
| concepts[4].id | https://openalex.org/C2909623084 |
| concepts[4].level | 4 |
| concepts[4].score | 0.47566741704940796 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q5331908 |
| concepts[4].display_name | Ebolavirus |
| concepts[5].id | https://openalex.org/C2522874641 |
| concepts[5].level | 2 |
| concepts[5].score | 0.47165170311927795 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[5].display_name | Virus |
| concepts[6].id | https://openalex.org/C185592680 |
| concepts[6].level | 0 |
| concepts[6].score | 0.39546269178390503 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[6].display_name | Chemistry |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.28305643796920776 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C55493867 |
| concepts[8].level | 1 |
| concepts[8].score | 0.1256117820739746 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[8].display_name | Biochemistry |
| concepts[9].id | https://openalex.org/C18903297 |
| concepts[9].level | 1 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7150 |
| concepts[9].display_name | Ecology |
| keywords[0].id | https://openalex.org/keywords/ebola-virus |
| keywords[0].score | 0.8694330453872681 |
| keywords[0].display_name | Ebola virus |
| keywords[1].id | https://openalex.org/keywords/repurposing |
| keywords[1].score | 0.8428542017936707 |
| keywords[1].display_name | Repurposing |
| keywords[2].id | https://openalex.org/keywords/virology |
| keywords[2].score | 0.6910676956176758 |
| keywords[2].display_name | Virology |
| keywords[3].id | https://openalex.org/keywords/glycoprotein |
| keywords[3].score | 0.5198929309844971 |
| keywords[3].display_name | Glycoprotein |
| keywords[4].id | https://openalex.org/keywords/ebolavirus |
| keywords[4].score | 0.47566741704940796 |
| keywords[4].display_name | Ebolavirus |
| keywords[5].id | https://openalex.org/keywords/virus |
| keywords[5].score | 0.47165170311927795 |
| keywords[5].display_name | Virus |
| keywords[6].id | https://openalex.org/keywords/chemistry |
| keywords[6].score | 0.39546269178390503 |
| keywords[6].display_name | Chemistry |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.28305643796920776 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/biochemistry |
| keywords[8].score | 0.1256117820739746 |
| keywords[8].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.21203/rs.3.rs-111854/v1 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402450 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Research Square (Research Square) |
| locations[0].source.host_organization | https://openalex.org/I4210096694 |
| locations[0].source.host_organization_name | Research Square (United States) |
| locations[0].source.host_organization_lineage | https://openalex.org/I4210096694 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-111854/v1.pdf?c=1606960441000 |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.3.rs-111854/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5025785786 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Shan Cen |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I200296433 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School |
| authorships[0].institutions[0].id | https://openalex.org/I200296433 |
| authorships[0].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Shan Cen |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School |
| authorships[1].author.id | https://openalex.org/A5007419462 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Dongrong Yi |
| authorships[1].countries | CN, GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I1302978242, https://openalex.org/I200296433 |
| authorships[1].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[1].institutions[0].id | https://openalex.org/I200296433 |
| authorships[1].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[1].institutions[1].id | https://openalex.org/I1302978242 |
| authorships[1].institutions[1].ror | https://ror.org/00c489v88 |
| authorships[1].institutions[1].type | nonprofit |
| authorships[1].institutions[1].lineage | https://openalex.org/I1302978242 |
| authorships[1].institutions[1].country_code | GB |
| authorships[1].institutions[1].display_name | Academy of Medical Sciences |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Dongrong Yi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[2].author.id | https://openalex.org/A5007387330 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-4151-0627 |
| authorships[2].author.display_name | Quanjie Li |
| authorships[2].countries | CN, GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1302978242, https://openalex.org/I200296433 |
| authorships[2].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[2].institutions[0].id | https://openalex.org/I200296433 |
| authorships[2].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[2].institutions[1].id | https://openalex.org/I1302978242 |
| authorships[2].institutions[1].ror | https://ror.org/00c489v88 |
| authorships[2].institutions[1].type | nonprofit |
| authorships[2].institutions[1].lineage | https://openalex.org/I1302978242 |
| authorships[2].institutions[1].country_code | GB |
| authorships[2].institutions[1].display_name | Academy of Medical Sciences |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Quanjie Li |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[3].author.id | https://openalex.org/A5041265645 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-5578-9999 |
| authorships[3].author.display_name | Xiangguo Qiu |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210125885 |
| authorships[3].affiliations[0].raw_affiliation_string | Public Health Agency |
| authorships[3].institutions[0].id | https://openalex.org/I4210125885 |
| authorships[3].institutions[0].ror | https://ror.org/03ek62e72 |
| authorships[3].institutions[0].type | other |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210125885 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | Public Health Agency |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Xiangguo Qiu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Public Health Agency |
| authorships[4].author.id | https://openalex.org/A5100452698 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-4086-5928 |
| authorships[4].author.display_name | Han Wang |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I19820366 |
| authorships[4].affiliations[0].raw_affiliation_string | Beijing Institutes of Life Science, Chinese Academy of Sciences |
| authorships[4].institutions[0].id | https://openalex.org/I19820366 |
| authorships[4].institutions[0].ror | https://ror.org/034t30j35 |
| authorships[4].institutions[0].type | government |
| authorships[4].institutions[0].lineage | https://openalex.org/I19820366 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Chinese Academy of Sciences |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Han Wang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Beijing Institutes of Life Science, Chinese Academy of Sciences |
| authorships[5].author.id | https://openalex.org/A5079652468 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-9149-7179 |
| authorships[5].author.display_name | Zhenlong Liu |
| authorships[5].countries | CA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2801824472 |
| authorships[5].affiliations[0].raw_affiliation_string | Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital |
| authorships[5].institutions[0].id | https://openalex.org/I2801824472 |
| authorships[5].institutions[0].ror | https://ror.org/056jjra10 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I2801824472 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | Jewish General Hospital |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Zhenlong Liu |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Lady Davis Institute for Medical Research and McGill AIDS Centre, Jewish General Hospital |
| authorships[6].author.id | https://openalex.org/A5003556936 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Shihua He |
| authorships[6].countries | CA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I177235860 |
| authorships[6].affiliations[0].raw_affiliation_string | Public Health Agency of Canada |
| authorships[6].institutions[0].id | https://openalex.org/I177235860 |
| authorships[6].institutions[0].ror | https://ror.org/023xf2a37 |
| authorships[6].institutions[0].type | government |
| authorships[6].institutions[0].lineage | https://openalex.org/I1288894424, https://openalex.org/I177235860 |
| authorships[6].institutions[0].country_code | CA |
| authorships[6].institutions[0].display_name | Public Health Agency of Canada |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Shihua He |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Public Health Agency of Canada |
| authorships[7].author.id | https://openalex.org/A5090865109 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6579-9891 |
| authorships[7].author.display_name | Wenjun Zhu |
| authorships[7].countries | CA |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I177235860 |
| authorships[7].affiliations[0].raw_affiliation_string | Public Health Agency of Canada |
| authorships[7].institutions[0].id | https://openalex.org/I177235860 |
| authorships[7].institutions[0].ror | https://ror.org/023xf2a37 |
| authorships[7].institutions[0].type | government |
| authorships[7].institutions[0].lineage | https://openalex.org/I1288894424, https://openalex.org/I177235860 |
| authorships[7].institutions[0].country_code | CA |
| authorships[7].institutions[0].display_name | Public Health Agency of Canada |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Wenjun Zhu |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Public Health Agency of Canada |
| authorships[8].author.id | https://openalex.org/A5016783413 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-6534-3627 |
| authorships[8].author.display_name | Kai Lv |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I200296433 |
| authorships[8].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School |
| authorships[8].institutions[0].id | https://openalex.org/I200296433 |
| authorships[8].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Kai Lv Lv |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School |
| authorships[9].author.id | https://openalex.org/A5072229255 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-0580-5997 |
| authorships[9].author.display_name | Xiangyang Chi |
| authorships[9].countries | CA |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I177235860 |
| authorships[9].affiliations[0].raw_affiliation_string | Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada |
| authorships[9].institutions[0].id | https://openalex.org/I177235860 |
| authorships[9].institutions[0].ror | https://ror.org/023xf2a37 |
| authorships[9].institutions[0].type | government |
| authorships[9].institutions[0].lineage | https://openalex.org/I1288894424, https://openalex.org/I177235860 |
| authorships[9].institutions[0].country_code | CA |
| authorships[9].institutions[0].display_name | Public Health Agency of Canada |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Xiangyang Chi |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada |
| authorships[10].author.id | https://openalex.org/A5091351581 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Ling Ma |
| authorships[10].countries | CN, GB |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I1302978242, https://openalex.org/I200296433 |
| authorships[10].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[10].institutions[0].id | https://openalex.org/I200296433 |
| authorships[10].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[10].institutions[1].id | https://openalex.org/I1302978242 |
| authorships[10].institutions[1].ror | https://ror.org/00c489v88 |
| authorships[10].institutions[1].type | nonprofit |
| authorships[10].institutions[1].lineage | https://openalex.org/I1302978242 |
| authorships[10].institutions[1].country_code | GB |
| authorships[10].institutions[1].display_name | Academy of Medical Sciences |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Ling Ma |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[11].author.id | https://openalex.org/A5100767797 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-9716-1115 |
| authorships[11].author.display_name | Yujia Wang |
| authorships[11].countries | CN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I200296433 |
| authorships[11].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School |
| authorships[11].institutions[0].id | https://openalex.org/I200296433 |
| authorships[11].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[11].institutions[0].country_code | CN |
| authorships[11].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Yujia Wang |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School |
| authorships[12].author.id | https://openalex.org/A5115694897 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-7431-8925 |
| authorships[12].author.display_name | Jing Wang |
| authorships[12].countries | CN, GB |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I1302978242, https://openalex.org/I200296433 |
| authorships[12].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[12].institutions[0].id | https://openalex.org/I200296433 |
| authorships[12].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[12].institutions[0].country_code | CN |
| authorships[12].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[12].institutions[1].id | https://openalex.org/I1302978242 |
| authorships[12].institutions[1].ror | https://ror.org/00c489v88 |
| authorships[12].institutions[1].type | nonprofit |
| authorships[12].institutions[1].lineage | https://openalex.org/I1302978242 |
| authorships[12].institutions[1].country_code | GB |
| authorships[12].institutions[1].display_name | Academy of Medical Sciences |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Jing Wang |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[13].author.id | https://openalex.org/A5100768240 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-8300-7659 |
| authorships[13].author.display_name | Yongxin Zhang |
| authorships[13].countries | CN, GB |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I1302978242, https://openalex.org/I200296433 |
| authorships[13].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[13].institutions[0].id | https://openalex.org/I200296433 |
| authorships[13].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[13].institutions[0].country_code | CN |
| authorships[13].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[13].institutions[1].id | https://openalex.org/I1302978242 |
| authorships[13].institutions[1].ror | https://ror.org/00c489v88 |
| authorships[13].institutions[1].type | nonprofit |
| authorships[13].institutions[1].lineage | https://openalex.org/I1302978242 |
| authorships[13].institutions[1].country_code | GB |
| authorships[13].institutions[1].display_name | Academy of Medical Sciences |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Yongxin Zhang |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[14].author.id | https://openalex.org/A5039431143 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-4423-3634 |
| authorships[14].author.display_name | Cong Zeng |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I52357470 |
| authorships[14].affiliations[0].raw_affiliation_string | Center for Retrovirus Research, The Ohio State University |
| authorships[14].institutions[0].id | https://openalex.org/I52357470 |
| authorships[14].institutions[0].ror | https://ror.org/00rs6vg23 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I52357470 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | The Ohio State University |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Cong Zeng |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Center for Retrovirus Research, The Ohio State University |
| authorships[15].author.id | https://openalex.org/A5100616088 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-8491-8115 |
| authorships[15].author.display_name | Mingliang Liu |
| authorships[15].countries | CN |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I200296433 |
| authorships[15].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School |
| authorships[15].institutions[0].id | https://openalex.org/I200296433 |
| authorships[15].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[15].institutions[0].country_code | CN |
| authorships[15].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Mingliang Liu |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical School |
| authorships[16].author.id | https://openalex.org/A5051784418 |
| authorships[16].author.orcid | |
| authorships[16].author.display_name | Shanlv Liu |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I52357470 |
| authorships[16].affiliations[0].raw_affiliation_string | Center for Retrovirus Research, The Ohio State University; |
| authorships[16].institutions[0].id | https://openalex.org/I52357470 |
| authorships[16].institutions[0].ror | https://ror.org/00rs6vg23 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I52357470 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | The Ohio State University |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Shanlv Liu |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Center for Retrovirus Research, The Ohio State University; |
| authorships[17].author.id | https://openalex.org/A5044530218 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-1552-2077 |
| authorships[17].author.display_name | Chen Liang |
| authorships[17].countries | CA |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I2801824472 |
| authorships[17].affiliations[0].raw_affiliation_string | Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University |
| authorships[17].institutions[0].id | https://openalex.org/I2801824472 |
| authorships[17].institutions[0].ror | https://ror.org/056jjra10 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I2801824472 |
| authorships[17].institutions[0].country_code | CA |
| authorships[17].institutions[0].display_name | Jewish General Hospital |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Chen Liang |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University |
| authorships[18].author.id | https://openalex.org/A5100449141 |
| authorships[18].author.orcid | https://orcid.org/0000-0002-0241-6152 |
| authorships[18].author.display_name | Xiaoyu Li |
| authorships[18].countries | CN, GB |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I1302978242, https://openalex.org/I200296433 |
| authorships[18].affiliations[0].raw_affiliation_string | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[18].institutions[0].id | https://openalex.org/I200296433 |
| authorships[18].institutions[0].ror | https://ror.org/02drdmm93 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I200296433 |
| authorships[18].institutions[0].country_code | CN |
| authorships[18].institutions[0].display_name | Chinese Academy of Medical Sciences & Peking Union Medical College |
| authorships[18].institutions[1].id | https://openalex.org/I1302978242 |
| authorships[18].institutions[1].ror | https://ror.org/00c489v88 |
| authorships[18].institutions[1].type | nonprofit |
| authorships[18].institutions[1].lineage | https://openalex.org/I1302978242 |
| authorships[18].institutions[1].country_code | GB |
| authorships[18].institutions[1].display_name | Academy of Medical Sciences |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Xiaoyu Li |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences |
| authorships[19].author.id | https://openalex.org/A5085318497 |
| authorships[19].author.orcid | https://orcid.org/0000-0001-8390-2648 |
| authorships[19].author.display_name | Logan Banadyga |
| authorships[19].countries | US |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I4210142152 |
| authorships[19].affiliations[0].raw_affiliation_string | ORCiD: https://orcid.org/0000-0001-8390-2648 |
| authorships[19].institutions[0].id | https://openalex.org/I4210142152 |
| authorships[19].institutions[0].ror | https://ror.org/04fa4r544 |
| authorships[19].institutions[0].type | nonprofit |
| authorships[19].institutions[0].lineage | https://openalex.org/I4210142152 |
| authorships[19].institutions[0].country_code | US |
| authorships[19].institutions[0].display_name | ORCID |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Logan Banadyga |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | ORCiD: https://orcid.org/0000-0001-8390-2648 |
| authorships[20].author.id | https://openalex.org/A5074385201 |
| authorships[20].author.orcid | https://orcid.org/0000-0002-3053-2687 |
| authorships[20].author.display_name | Yi Shi |
| authorships[20].countries | CN, CZ, US |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I4210142152 |
| authorships[20].affiliations[0].raw_affiliation_string | ORCiD: https://orcid.org/0000-0002-3053-2687 |
| authorships[20].affiliations[1].institution_ids | https://openalex.org/I19820366, https://openalex.org/I4210122847 |
| authorships[20].affiliations[1].raw_affiliation_string | Institute of Microbiology, Chinese Academy of Sciences |
| authorships[20].institutions[0].id | https://openalex.org/I19820366 |
| authorships[20].institutions[0].ror | https://ror.org/034t30j35 |
| authorships[20].institutions[0].type | government |
| authorships[20].institutions[0].lineage | https://openalex.org/I19820366 |
| authorships[20].institutions[0].country_code | CN |
| authorships[20].institutions[0].display_name | Chinese Academy of Sciences |
| authorships[20].institutions[1].id | https://openalex.org/I4210122847 |
| authorships[20].institutions[1].ror | https://ror.org/02p1jz666 |
| authorships[20].institutions[1].type | facility |
| authorships[20].institutions[1].lineage | https://openalex.org/I202391551, https://openalex.org/I4210122847 |
| authorships[20].institutions[1].country_code | CZ |
| authorships[20].institutions[1].display_name | Czech Academy of Sciences, Institute of Microbiology |
| authorships[20].institutions[2].id | https://openalex.org/I4210142152 |
| authorships[20].institutions[2].ror | https://ror.org/04fa4r544 |
| authorships[20].institutions[2].type | nonprofit |
| authorships[20].institutions[2].lineage | https://openalex.org/I4210142152 |
| authorships[20].institutions[2].country_code | US |
| authorships[20].institutions[2].display_name | ORCID |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Yi Shi |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Institute of Microbiology, Chinese Academy of Sciences, ORCiD: https://orcid.org/0000-0002-3053-2687 |
| authorships[21].author.id | https://openalex.org/A5015873777 |
| authorships[21].author.orcid | https://orcid.org/0000-0002-3869-615X |
| authorships[21].author.display_name | George F. Gao |
| authorships[21].countries | CN, TW, US |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I4210140459, https://openalex.org/I4210140986 |
| authorships[21].affiliations[0].raw_affiliation_string | NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention |
| authorships[21].affiliations[1].institution_ids | https://openalex.org/I4210142152 |
| authorships[21].affiliations[1].raw_affiliation_string | ORCiD: https://orcid.org/0000-0002-3869-615X |
| authorships[21].institutions[0].id | https://openalex.org/I4210140986 |
| authorships[21].institutions[0].ror | https://ror.org/04b1sh213 |
| authorships[21].institutions[0].type | government |
| authorships[21].institutions[0].lineage | https://openalex.org/I184490438, https://openalex.org/I4210127390, https://openalex.org/I4210140986, https://openalex.org/I4210151987 |
| authorships[21].institutions[0].country_code | CN |
| authorships[21].institutions[0].display_name | National Institute for Viral Disease Control and Prevention |
| authorships[21].institutions[1].id | https://openalex.org/I4210140459 |
| authorships[21].institutions[1].ror | https://ror.org/04hsdam77 |
| authorships[21].institutions[1].type | facility |
| authorships[21].institutions[1].lineage | https://openalex.org/I4210140459 |
| authorships[21].institutions[1].country_code | TW |
| authorships[21].institutions[1].display_name | Center for Disease Control |
| authorships[21].institutions[2].id | https://openalex.org/I4210142152 |
| authorships[21].institutions[2].ror | https://ror.org/04fa4r544 |
| authorships[21].institutions[2].type | nonprofit |
| authorships[21].institutions[2].lineage | https://openalex.org/I4210142152 |
| authorships[21].institutions[2].country_code | US |
| authorships[21].institutions[2].display_name | ORCID |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | George Fu Gao |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, ORCiD: https://orcid.org/0000-0002-3869-615X |
| authorships[22].author.id | https://openalex.org/A5003682597 |
| authorships[22].author.orcid | https://orcid.org/0000-0002-2238-3503 |
| authorships[22].author.display_name | Rongtuan Lin |
| authorships[22].countries | CA |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[22].affiliations[0].raw_affiliation_string | McGill University |
| authorships[22].institutions[0].id | https://openalex.org/I5023651 |
| authorships[22].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[22].institutions[0].type | education |
| authorships[22].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[22].institutions[0].country_code | CA |
| authorships[22].institutions[0].display_name | McGill University |
| authorships[22].author_position | last |
| authorships[22].raw_author_name | Rongtuan Lin |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | McGill University |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-111854/v1.pdf?c=1606960441000 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Repurposing of Berbamine Hydrochloride to Inhibit Ebola Virus by Targeting Viral Glycoprotein |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11581 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | Viral Infections and Outbreaks Research |
| related_works | https://openalex.org/W2625387716, https://openalex.org/W2051802868, https://openalex.org/W2056946199, https://openalex.org/W2968139870, https://openalex.org/W4200430107, https://openalex.org/W1491619488, https://openalex.org/W2016869562, https://openalex.org/W2579764090, https://openalex.org/W2588428923, https://openalex.org/W2932598530 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2023 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.3.rs-111854/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402450 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Research Square (Research Square) |
| best_oa_location.source.host_organization | https://openalex.org/I4210096694 |
| best_oa_location.source.host_organization_name | Research Square (United States) |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-111854/v1.pdf?c=1606960441000 |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-111854/v1 |
| primary_location.id | doi:10.21203/rs.3.rs-111854/v1 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402450 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Research Square (Research Square) |
| primary_location.source.host_organization | https://openalex.org/I4210096694 |
| primary_location.source.host_organization_name | Research Square (United States) |
| primary_location.source.host_organization_lineage | https://openalex.org/I4210096694 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-111854/v1.pdf?c=1606960441000 |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-111854/v1 |
| publication_date | 2020-12-02 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W6808133917, https://openalex.org/W1984322059, https://openalex.org/W2080374377, https://openalex.org/W2110951885, https://openalex.org/W2396636851, https://openalex.org/W1760776415, https://openalex.org/W2001327611, https://openalex.org/W2274478712, https://openalex.org/W2346830803, https://openalex.org/W2555975000, https://openalex.org/W2138289533, https://openalex.org/W2166553704, https://openalex.org/W2238087249, https://openalex.org/W2466466163, https://openalex.org/W2043829974, https://openalex.org/W2802879487, https://openalex.org/W2405499254, https://openalex.org/W2105513391, https://openalex.org/W2016230098, https://openalex.org/W2079526653, https://openalex.org/W2237639303, https://openalex.org/W6638963510, https://openalex.org/W2029379203, https://openalex.org/W2107717338, https://openalex.org/W2150451731, https://openalex.org/W2169678694, https://openalex.org/W2962765467, https://openalex.org/W1996037007, https://openalex.org/W2022339063, https://openalex.org/W2043620814, https://openalex.org/W2102286438, https://openalex.org/W4320995993, https://openalex.org/W2777797644, https://openalex.org/W2134967712, https://openalex.org/W2142868265 |
| referenced_works_count | 35 |
| abstract_inverted_index.a | 31 |
| abstract_inverted_index.In | 25 |
| abstract_inverted_index.an | 116 |
| abstract_inverted_index.as | 115 |
| abstract_inverted_index.by | 54, 90 |
| abstract_inverted_index.in | 23, 41, 44, 102 |
| abstract_inverted_index.it | 107 |
| abstract_inverted_index.of | 74, 84, 111 |
| abstract_inverted_index.to | 6, 18, 57, 104 |
| abstract_inverted_index.we | 28 |
| abstract_inverted_index.Our | 46, 79 |
| abstract_inverted_index.and | 12, 43, 76 |
| abstract_inverted_index.are | 15 |
| abstract_inverted_index.has | 99 |
| abstract_inverted_index.the | 58, 72, 82 |
| abstract_inverted_index.EBOV | 21, 39, 60 |
| abstract_inverted_index.GPcl | 64 |
| abstract_inverted_index.More | 94 |
| abstract_inverted_index.acts | 53 |
| abstract_inverted_index.been | 100 |
| abstract_inverted_index.data | 80 |
| abstract_inverted_index.high | 8 |
| abstract_inverted_index.that | 30, 50 |
| abstract_inverted_index.this | 26 |
| abstract_inverted_index.thus | 70 |
| abstract_inverted_index.used | 101 |
| abstract_inverted_index.with | 66 |
| abstract_inverted_index.work | 47 |
| abstract_inverted_index.Ebola | 1 |
| abstract_inverted_index.GPcl. | 93 |
| abstract_inverted_index.NPC1, | 69 |
| abstract_inverted_index.being | 112 |
| abstract_inverted_index.drug. | 118 |
| abstract_inverted_index.drugs | 89 |
| abstract_inverted_index.great | 109 |
| abstract_inverted_index.holds | 108 |
| abstract_inverted_index.leads | 5 |
| abstract_inverted_index.since | 96 |
| abstract_inverted_index.small | 87 |
| abstract_inverted_index.treat | 105 |
| abstract_inverted_index.viral | 67, 75, 92 |
| abstract_inverted_index.virus | 2 |
| abstract_inverted_index.vitro | 42 |
| abstract_inverted_index.vivo. | 45 |
| abstract_inverted_index.(EBOV) | 3 |
| abstract_inverted_index.called | 34 |
| abstract_inverted_index.clinic | 103 |
| abstract_inverted_index.direct | 55 |
| abstract_inverted_index.fusion | 73 |
| abstract_inverted_index.needed | 17 |
| abstract_inverted_index.rates. | 10 |
| abstract_inverted_index.report | 29 |
| abstract_inverted_index.showed | 49 |
| abstract_inverted_index.study, | 27 |
| abstract_inverted_index.(GPcl), | 62 |
| abstract_inverted_index.Africa. | 24 |
| abstract_inverted_index.binding | 56 |
| abstract_inverted_index.cleaved | 59 |
| abstract_inverted_index.control | 19 |
| abstract_inverted_index.further | 48 |
| abstract_inverted_index.natural | 32 |
| abstract_inverted_index.promise | 110 |
| abstract_inverted_index.quickly | 113 |
| abstract_inverted_index.support | 81 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.blocking | 71 |
| abstract_inverted_index.cellular | 77 |
| abstract_inverted_index.compound | 33 |
| abstract_inverted_index.frequent | 20 |
| abstract_inverted_index.inhibits | 38 |
| abstract_inverted_index.low-cost | 13 |
| abstract_inverted_index.molecule | 88 |
| abstract_inverted_index.receptor | 68 |
| abstract_inverted_index.strongly | 37 |
| abstract_inverted_index.urgently | 16 |
| abstract_inverted_index.Effective | 11 |
| abstract_inverted_index.anti-EBOV | 86, 117 |
| abstract_inverted_index.berbamine | 35, 51, 97 |
| abstract_inverted_index.infection | 4 |
| abstract_inverted_index.mortality | 9 |
| abstract_inverted_index.outbreaks | 22 |
| abstract_inverted_index.targeting | 91 |
| abstract_inverted_index.developing | 85 |
| abstract_inverted_index.disrupting | 63 |
| abstract_inverted_index.membranes. | 78 |
| abstract_inverted_index.repurposed | 114 |
| abstract_inverted_index.treatments | 14 |
| abstract_inverted_index.interaction | 65 |
| abstract_inverted_index.leukopenia, | 106 |
| abstract_inverted_index.probability | 83 |
| abstract_inverted_index.replication | 40 |
| abstract_inverted_index.glycoprotein | 61 |
| abstract_inverted_index.importantly, | 95 |
| abstract_inverted_index.staggeringly | 7 |
| abstract_inverted_index.hydrochloride | 36, 52, 98 |
| cited_by_percentile_year.max | 94 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5025785786 |
| countries_distinct_count | 6 |
| institutions_distinct_count | 23 |
| corresponding_institution_ids | https://openalex.org/I200296433 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.41294182 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |