Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia Article Swipe
Tobias Weinberger
,
Denise Messerer
,
Markus Joppich
,
Maximilian Fischer
,
Clarisabel Garcia
,
Konda Kumaraswami
,
Vanessa Wimmler
,
Sonja Ablinger
,
Saskia Räuber
,
Jiahui Fang
,
Lulu Liu
,
Wing Han Liu
,
Julia Winterhalter
,
Johannes Lichti
,
Lukas Tomas
,
Dena Esfandyari
,
Guelce Percin
,
Sandra Martin Salamanca
,
Andrés Hidalgo
,
Claudia Waskow
,
Stefan Engelhardt
,
Andrei Todica
,
Ralf Zimmer
,
Clare Pridans
,
Elisa Gomez Perdiguero
,
Christian Schulz
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.05.08.539799
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.05.08.539799
Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion injury remains incomplete. We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. Genomic deletion of a fms-intronic regulatory element (FIRE) in the Csf1r locus resulted in specific absence of resident homeostatic and antigen-presenting macrophages, without affecting the recruitment of monocyte-derived macrophages to the infarcted heart. Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodelling without influencing infarct size. In contrast, continuous CSF1R inhibition led to depletion of both resident and recruited macrophage populations. This augmented adverse remodelling after I/R and led to an increased infarct size and deterioration of cardiac function. In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodelling, while recruited macrophages determine infarct size after I/R injury. These findings attribute distinct beneficial effects to different macrophage populations in the context of myocardial infarction. GRAPHICAL ABSTRACT
Related Topics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.05.08.539799
- https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.05.08.539799.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 69
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4377115374
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4377115374Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.05.08.539799Digital Object Identifier
- Title
-
Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemiaWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-05-09Full publication date if available
- Authors
-
Tobias Weinberger, Denise Messerer, Markus Joppich, Maximilian Fischer, Clarisabel Garcia, Konda Kumaraswami, Vanessa Wimmler, Sonja Ablinger, Saskia Räuber, Jiahui Fang, Lulu Liu, Wing Han Liu, Julia Winterhalter, Johannes Lichti, Lukas Tomas, Dena Esfandyari, Guelce Percin, Sandra Martin Salamanca, Andrés Hidalgo, Claudia Waskow, Stefan Engelhardt, Andrei Todica, Ralf Zimmer, Clare Pridans, Elisa Gomez Perdiguero, Christian SchulzList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.05.08.539799Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.05.08.539799.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.05.08.539799.full.pdfDirect OA link when available
- Concepts
-
Myocardial ischemia, Medicine, Ischemia, Cardiology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
69Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4377115374 |
|---|---|
| doi | https://doi.org/10.1101/2023.05.08.539799 |
| ids.doi | https://doi.org/10.1101/2023.05.08.539799 |
| ids.openalex | https://openalex.org/W4377115374 |
| fwci | 0.67143376 |
| type | preprint |
| title | Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T11962 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9988999962806702 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2705 |
| topics[0].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[0].display_name | Cardiac Fibrosis and Remodeling |
| topics[1].id | https://openalex.org/T11055 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9926999807357788 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2746 |
| topics[1].subfield.display_name | Surgery |
| topics[1].display_name | Cardiac and Coronary Surgery Techniques |
| topics[2].id | https://openalex.org/T13254 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9918000102043152 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Macrophage Migration Inhibitory Factor |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C3017461755 |
| concepts[0].level | 3 |
| concepts[0].score | 0.6761556267738342 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q844935 |
| concepts[0].display_name | Myocardial ischemia |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.5844261050224304 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C541997718 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5591722726821899 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q188151 |
| concepts[2].display_name | Ischemia |
| concepts[3].id | https://openalex.org/C164705383 |
| concepts[3].level | 1 |
| concepts[3].score | 0.5288580060005188 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q10379 |
| concepts[3].display_name | Cardiology |
| concepts[4].id | https://openalex.org/C126322002 |
| concepts[4].level | 1 |
| concepts[4].score | 0.4454779624938965 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[4].display_name | Internal medicine |
| keywords[0].id | https://openalex.org/keywords/myocardial-ischemia |
| keywords[0].score | 0.6761556267738342 |
| keywords[0].display_name | Myocardial ischemia |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.5844261050224304 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/ischemia |
| keywords[2].score | 0.5591722726821899 |
| keywords[2].display_name | Ischemia |
| keywords[3].id | https://openalex.org/keywords/cardiology |
| keywords[3].score | 0.5288580060005188 |
| keywords[3].display_name | Cardiology |
| keywords[4].id | https://openalex.org/keywords/internal-medicine |
| keywords[4].score | 0.4454779624938965 |
| keywords[4].display_name | Internal medicine |
| language | en |
| locations[0].id | doi:10.1101/2023.05.08.539799 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.05.08.539799.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2023.05.08.539799 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5088761449 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-0024-020X |
| authorships[0].author.display_name | Tobias Weinberger |
| authorships[0].countries | DE, FR |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I157536573, https://openalex.org/I4387153797 |
| authorships[0].affiliations[0].raw_affiliation_string | Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[0].affiliations[1].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I8204097 |
| authorships[0].affiliations[2].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[0].affiliations[3].institution_ids | https://openalex.org/I4210127591 |
| authorships[0].affiliations[3].raw_affiliation_string | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany |
| authorships[0].institutions[0].id | https://openalex.org/I4387153797 |
| authorships[0].institutions[0].ror | https://ror.org/02af93v77 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I1294671590, https://openalex.org/I157536573, https://openalex.org/I4387153797 |
| authorships[0].institutions[0].country_code | |
| authorships[0].institutions[0].display_name | Biologie du Développement et Cellules Souches |
| authorships[0].institutions[1].id | https://openalex.org/I4210127591 |
| authorships[0].institutions[1].ror | https://ror.org/031t5w623 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210127591, https://openalex.org/I4411590659 |
| authorships[0].institutions[1].country_code | DE |
| authorships[0].institutions[1].display_name | German Centre for Cardiovascular Research |
| authorships[0].institutions[2].id | https://openalex.org/I8204097 |
| authorships[0].institutions[2].ror | https://ror.org/05591te55 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I8204097 |
| authorships[0].institutions[2].country_code | DE |
| authorships[0].institutions[2].display_name | Ludwig-Maximilians-Universität München |
| authorships[0].institutions[3].id | https://openalex.org/I157536573 |
| authorships[0].institutions[3].ror | https://ror.org/0495fxg12 |
| authorships[0].institutions[3].type | nonprofit |
| authorships[0].institutions[3].lineage | https://openalex.org/I157536573 |
| authorships[0].institutions[3].country_code | FR |
| authorships[0].institutions[3].display_name | Institut Pasteur |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Tobias Weinberger |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany, Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France, Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[1].author.id | https://openalex.org/A5054211070 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Denise Messerer |
| authorships[1].countries | DE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[1].affiliations[0].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[1].affiliations[1].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[1].institutions[0].id | https://openalex.org/I8204097 |
| authorships[1].institutions[0].ror | https://ror.org/05591te55 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[1].institutions[0].country_code | DE |
| authorships[1].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Denise Messerer |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[2].author.id | https://openalex.org/A5054104640 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6665-8951 |
| authorships[2].author.display_name | Markus Joppich |
| authorships[2].countries | DE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[2].affiliations[0].raw_affiliation_string | LFE Bioinformatik, Department of Informatics, Ludwig Maximilian University, 80333 Munich, Germany |
| authorships[2].institutions[0].id | https://openalex.org/I8204097 |
| authorships[2].institutions[0].ror | https://ror.org/05591te55 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[2].institutions[0].country_code | DE |
| authorships[2].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Markus Joppich |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | LFE Bioinformatik, Department of Informatics, Ludwig Maximilian University, 80333 Munich, Germany |
| authorships[3].author.id | https://openalex.org/A5011939577 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9172-3316 |
| authorships[3].author.display_name | Maximilian Fischer |
| authorships[3].countries | DE |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[3].affiliations[0].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[3].affiliations[1].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[3].affiliations[2].institution_ids | https://openalex.org/I4210127591 |
| authorships[3].affiliations[2].raw_affiliation_string | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany |
| authorships[3].institutions[0].id | https://openalex.org/I4210127591 |
| authorships[3].institutions[0].ror | https://ror.org/031t5w623 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210127591, https://openalex.org/I4411590659 |
| authorships[3].institutions[0].country_code | DE |
| authorships[3].institutions[0].display_name | German Centre for Cardiovascular Research |
| authorships[3].institutions[1].id | https://openalex.org/I8204097 |
| authorships[3].institutions[1].ror | https://ror.org/05591te55 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[3].institutions[1].country_code | DE |
| authorships[3].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Max Fischer |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany, Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[4].author.id | https://openalex.org/A5102541257 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Clarisabel Garcia |
| authorships[4].countries | FR |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I157536573, https://openalex.org/I4387153797 |
| authorships[4].affiliations[0].raw_affiliation_string | Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France |
| authorships[4].institutions[0].id | https://openalex.org/I4387153797 |
| authorships[4].institutions[0].ror | https://ror.org/02af93v77 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I1294671590, https://openalex.org/I157536573, https://openalex.org/I4387153797 |
| authorships[4].institutions[0].country_code | |
| authorships[4].institutions[0].display_name | Biologie du Développement et Cellules Souches |
| authorships[4].institutions[1].id | https://openalex.org/I157536573 |
| authorships[4].institutions[1].ror | https://ror.org/0495fxg12 |
| authorships[4].institutions[1].type | nonprofit |
| authorships[4].institutions[1].lineage | https://openalex.org/I157536573 |
| authorships[4].institutions[1].country_code | FR |
| authorships[4].institutions[1].display_name | Institut Pasteur |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Clarisabel Garcia |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France |
| authorships[5].author.id | https://openalex.org/A5018031002 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-3984-7295 |
| authorships[5].author.display_name | Konda Kumaraswami |
| authorships[5].countries | DE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[5].affiliations[1].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[5].institutions[0].id | https://openalex.org/I8204097 |
| authorships[5].institutions[0].ror | https://ror.org/05591te55 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[5].institutions[0].country_code | DE |
| authorships[5].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Konda Kumaraswami |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[6].author.id | https://openalex.org/A5037659352 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Vanessa Wimmler |
| authorships[6].countries | DE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[6].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[6].affiliations[1].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[6].institutions[0].id | https://openalex.org/I8204097 |
| authorships[6].institutions[0].ror | https://ror.org/05591te55 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[6].institutions[0].country_code | DE |
| authorships[6].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Vanessa Wimmler |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[7].author.id | https://openalex.org/A5091982778 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Sonja Ablinger |
| authorships[7].countries | DE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[7].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[7].affiliations[1].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[7].institutions[0].id | https://openalex.org/I8204097 |
| authorships[7].institutions[0].ror | https://ror.org/05591te55 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[7].institutions[0].country_code | DE |
| authorships[7].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Sonja Ablinger |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[8].author.id | https://openalex.org/A5038485888 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-8901-5572 |
| authorships[8].author.display_name | Saskia Räuber |
| authorships[8].countries | DE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[8].affiliations[0].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I44260953 |
| authorships[8].affiliations[1].raw_affiliation_string | Department of Neurology, Medical Faculty, Heinrich Heine University of Düsseldorf, 40225 Düsseldorf, Germany |
| authorships[8].affiliations[2].institution_ids | https://openalex.org/I8204097 |
| authorships[8].affiliations[2].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[8].institutions[0].id | https://openalex.org/I44260953 |
| authorships[8].institutions[0].ror | https://ror.org/024z2rq82 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I44260953 |
| authorships[8].institutions[0].country_code | DE |
| authorships[8].institutions[0].display_name | Heinrich Heine University Düsseldorf |
| authorships[8].institutions[1].id | https://openalex.org/I8204097 |
| authorships[8].institutions[1].ror | https://ror.org/05591te55 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[8].institutions[1].country_code | DE |
| authorships[8].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Saskia Räuber |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Neurology, Medical Faculty, Heinrich Heine University of Düsseldorf, 40225 Düsseldorf, Germany, Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[9].author.id | https://openalex.org/A5101504464 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-9382-9341 |
| authorships[9].author.display_name | Jiahui Fang |
| authorships[9].countries | DE |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[9].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[9].affiliations[1].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[9].institutions[0].id | https://openalex.org/I8204097 |
| authorships[9].institutions[0].ror | https://ror.org/05591te55 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[9].institutions[0].country_code | DE |
| authorships[9].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Jiahui Fang |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[10].author.id | https://openalex.org/A5100404455 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-4016-0431 |
| authorships[10].author.display_name | Lulu Liu |
| authorships[10].countries | DE |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[10].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[10].affiliations[1].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[10].institutions[0].id | https://openalex.org/I8204097 |
| authorships[10].institutions[0].ror | https://ror.org/05591te55 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[10].institutions[0].country_code | DE |
| authorships[10].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Lulu Liu |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[11].author.id | https://openalex.org/A5071196336 |
| authorships[11].author.orcid | https://orcid.org/0009-0005-0246-6925 |
| authorships[11].author.display_name | Wing Han Liu |
| authorships[11].countries | DE |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[11].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[11].institutions[0].id | https://openalex.org/I8204097 |
| authorships[11].institutions[0].ror | https://ror.org/05591te55 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[11].institutions[0].country_code | DE |
| authorships[11].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Wing Han Liu |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[12].author.id | https://openalex.org/A5062575666 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Julia Winterhalter |
| authorships[12].countries | DE |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[12].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I8204097 |
| authorships[12].affiliations[1].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[12].institutions[0].id | https://openalex.org/I8204097 |
| authorships[12].institutions[0].ror | https://ror.org/05591te55 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[12].institutions[0].country_code | DE |
| authorships[12].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Julia Winterhalter |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[13].author.id | https://openalex.org/A5088533813 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Johannes Lichti |
| authorships[13].countries | DE |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[13].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[13].institutions[0].id | https://openalex.org/I8204097 |
| authorships[13].institutions[0].ror | https://ror.org/05591te55 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[13].institutions[0].country_code | DE |
| authorships[13].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Johannes Lichti |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[14].author.id | https://openalex.org/A5090894244 |
| authorships[14].author.orcid | https://orcid.org/0000-0001-9371-8721 |
| authorships[14].author.display_name | Lukas Tomas |
| authorships[14].countries | DE |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[14].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I4210127591 |
| authorships[14].affiliations[1].raw_affiliation_string | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I8204097 |
| authorships[14].affiliations[2].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[14].institutions[0].id | https://openalex.org/I4210127591 |
| authorships[14].institutions[0].ror | https://ror.org/031t5w623 |
| authorships[14].institutions[0].type | facility |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210127591, https://openalex.org/I4411590659 |
| authorships[14].institutions[0].country_code | DE |
| authorships[14].institutions[0].display_name | German Centre for Cardiovascular Research |
| authorships[14].institutions[1].id | https://openalex.org/I8204097 |
| authorships[14].institutions[1].ror | https://ror.org/05591te55 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[14].institutions[1].country_code | DE |
| authorships[14].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Lukas Tomas |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany, Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[15].author.id | https://openalex.org/A5006760628 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-8732-1461 |
| authorships[15].author.display_name | Dena Esfandyari |
| authorships[15].countries | DE |
| authorships[15].affiliations[0].raw_affiliation_string | Institute of Pharmacology and Toxicology, Technical University Munich, 80802 Munich, Germany |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I4210127591 |
| authorships[15].affiliations[1].raw_affiliation_string | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany |
| authorships[15].institutions[0].id | https://openalex.org/I4210127591 |
| authorships[15].institutions[0].ror | https://ror.org/031t5w623 |
| authorships[15].institutions[0].type | facility |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210127591, https://openalex.org/I4411590659 |
| authorships[15].institutions[0].country_code | DE |
| authorships[15].institutions[0].display_name | German Centre for Cardiovascular Research |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Dena Esfandyari |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany, Institute of Pharmacology and Toxicology, Technical University Munich, 80802 Munich, Germany |
| authorships[16].author.id | https://openalex.org/A5091982777 |
| authorships[16].author.orcid | |
| authorships[16].author.display_name | Guelce Percin |
| authorships[16].countries | DE |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I4210127789 |
| authorships[16].affiliations[0].raw_affiliation_string | Immunology of Aging, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), 07745 Jena, Germany |
| authorships[16].institutions[0].id | https://openalex.org/I4210127789 |
| authorships[16].institutions[0].ror | https://ror.org/039a53269 |
| authorships[16].institutions[0].type | facility |
| authorships[16].institutions[0].lineage | https://openalex.org/I315704651, https://openalex.org/I4210127789 |
| authorships[16].institutions[0].country_code | DE |
| authorships[16].institutions[0].display_name | Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Guelce Percin |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Immunology of Aging, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), 07745 Jena, Germany |
| authorships[17].author.id | https://openalex.org/A5113131954 |
| authorships[17].author.orcid | |
| authorships[17].author.display_name | Sandra Martin Salamanca |
| authorships[17].countries | ES |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I2809107791 |
| authorships[17].affiliations[0].raw_affiliation_string | Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain |
| authorships[17].institutions[0].id | https://openalex.org/I2809107791 |
| authorships[17].institutions[0].ror | https://ror.org/02qs1a797 |
| authorships[17].institutions[0].type | facility |
| authorships[17].institutions[0].lineage | https://openalex.org/I2809107791, https://openalex.org/I4210098440 |
| authorships[17].institutions[0].country_code | ES |
| authorships[17].institutions[0].display_name | Spanish National Centre for Cardiovascular Research |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Sandra Martin Salamanca |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain |
| authorships[18].author.id | https://openalex.org/A5085568242 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-5513-555X |
| authorships[18].author.display_name | Andrés Hidalgo |
| authorships[18].countries | ES, US |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I32971472 |
| authorships[18].affiliations[0].raw_affiliation_string | Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA |
| authorships[18].affiliations[1].institution_ids | https://openalex.org/I2809107791 |
| authorships[18].affiliations[1].raw_affiliation_string | Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain |
| authorships[18].institutions[0].id | https://openalex.org/I2809107791 |
| authorships[18].institutions[0].ror | https://ror.org/02qs1a797 |
| authorships[18].institutions[0].type | facility |
| authorships[18].institutions[0].lineage | https://openalex.org/I2809107791, https://openalex.org/I4210098440 |
| authorships[18].institutions[0].country_code | ES |
| authorships[18].institutions[0].display_name | Spanish National Centre for Cardiovascular Research |
| authorships[18].institutions[1].id | https://openalex.org/I32971472 |
| authorships[18].institutions[1].ror | https://ror.org/03v76x132 |
| authorships[18].institutions[1].type | education |
| authorships[18].institutions[1].lineage | https://openalex.org/I32971472 |
| authorships[18].institutions[1].country_code | US |
| authorships[18].institutions[1].display_name | Yale University |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Andres Hidalgo |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Area of Cell & Developmental Biology, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain, Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA |
| authorships[19].author.id | https://openalex.org/A5091669415 |
| authorships[19].author.orcid | https://orcid.org/0000-0003-3261-0922 |
| authorships[19].author.display_name | Claudia Waskow |
| authorships[19].countries | DE |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I76198965 |
| authorships[19].affiliations[0].raw_affiliation_string | Faculty of Biological Sciences, Friedrich-Schiller-University, 07737 Jena, Germany |
| authorships[19].affiliations[1].institution_ids | https://openalex.org/I4210127789 |
| authorships[19].affiliations[1].raw_affiliation_string | Immunology of Aging, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), 07745 Jena, Germany |
| authorships[19].institutions[0].id | https://openalex.org/I76198965 |
| authorships[19].institutions[0].ror | https://ror.org/05qpz1x62 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I76198965 |
| authorships[19].institutions[0].country_code | DE |
| authorships[19].institutions[0].display_name | Friedrich Schiller University Jena |
| authorships[19].institutions[1].id | https://openalex.org/I4210127789 |
| authorships[19].institutions[1].ror | https://ror.org/039a53269 |
| authorships[19].institutions[1].type | facility |
| authorships[19].institutions[1].lineage | https://openalex.org/I315704651, https://openalex.org/I4210127789 |
| authorships[19].institutions[1].country_code | DE |
| authorships[19].institutions[1].display_name | Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Claudia Waskow |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Faculty of Biological Sciences, Friedrich-Schiller-University, 07737 Jena, Germany, Immunology of Aging, Leibniz-Institute on Aging - Fritz-Lipmann-Institute (FLI), 07745 Jena, Germany |
| authorships[20].author.id | https://openalex.org/A5073084904 |
| authorships[20].author.orcid | https://orcid.org/0000-0001-5378-8661 |
| authorships[20].author.display_name | Stefan Engelhardt |
| authorships[20].countries | DE |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I4210127591 |
| authorships[20].affiliations[0].raw_affiliation_string | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany |
| authorships[20].affiliations[1].raw_affiliation_string | Institute of Pharmacology and Toxicology, Technical University Munich, 80802 Munich, Germany |
| authorships[20].institutions[0].id | https://openalex.org/I4210127591 |
| authorships[20].institutions[0].ror | https://ror.org/031t5w623 |
| authorships[20].institutions[0].type | facility |
| authorships[20].institutions[0].lineage | https://openalex.org/I4210127591, https://openalex.org/I4411590659 |
| authorships[20].institutions[0].country_code | DE |
| authorships[20].institutions[0].display_name | German Centre for Cardiovascular Research |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Stefan Engelhardt |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany, Institute of Pharmacology and Toxicology, Technical University Munich, 80802 Munich, Germany |
| authorships[21].author.id | https://openalex.org/A5002308372 |
| authorships[21].author.orcid | https://orcid.org/0000-0003-1504-6565 |
| authorships[21].author.display_name | Andrei Todica |
| authorships[21].countries | DE |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[21].affiliations[0].raw_affiliation_string | Department of Nuclear Medicine, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[21].institutions[0].id | https://openalex.org/I8204097 |
| authorships[21].institutions[0].ror | https://ror.org/05591te55 |
| authorships[21].institutions[0].type | education |
| authorships[21].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[21].institutions[0].country_code | DE |
| authorships[21].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Andrei Todica |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Department of Nuclear Medicine, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[22].author.id | https://openalex.org/A5068859428 |
| authorships[22].author.orcid | https://orcid.org/0000-0003-1439-2327 |
| authorships[22].author.display_name | Ralf Zimmer |
| authorships[22].countries | DE |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[22].affiliations[0].raw_affiliation_string | LFE Bioinformatik, Department of Informatics, Ludwig Maximilian University, 80333 Munich, Germany |
| authorships[22].institutions[0].id | https://openalex.org/I8204097 |
| authorships[22].institutions[0].ror | https://ror.org/05591te55 |
| authorships[22].institutions[0].type | education |
| authorships[22].institutions[0].lineage | https://openalex.org/I8204097 |
| authorships[22].institutions[0].country_code | DE |
| authorships[22].institutions[0].display_name | Ludwig-Maximilians-Universität München |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Ralf Zimmer |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | LFE Bioinformatik, Department of Informatics, Ludwig Maximilian University, 80333 Munich, Germany |
| authorships[23].author.id | https://openalex.org/A5040837932 |
| authorships[23].author.orcid | https://orcid.org/0000-0001-9423-557X |
| authorships[23].author.display_name | Clare Pridans |
| authorships[23].countries | GB |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I4210151647, https://openalex.org/I4210164624, https://openalex.org/I98677209 |
| authorships[23].affiliations[0].raw_affiliation_string | University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom |
| authorships[23].affiliations[1].institution_ids | https://openalex.org/I98677209 |
| authorships[23].affiliations[1].raw_affiliation_string | Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom |
| authorships[23].institutions[0].id | https://openalex.org/I4210151647 |
| authorships[23].institutions[0].ror | https://ror.org/05wcr1b38 |
| authorships[23].institutions[0].type | facility |
| authorships[23].institutions[0].lineage | https://openalex.org/I4210087105, https://openalex.org/I4210151647, https://openalex.org/I90344618, https://openalex.org/I98677209 |
| authorships[23].institutions[0].country_code | GB |
| authorships[23].institutions[0].display_name | Centre for Inflammation Research |
| authorships[23].institutions[1].id | https://openalex.org/I4210164624 |
| authorships[23].institutions[1].ror | https://ror.org/059zxg644 |
| authorships[23].institutions[1].type | government |
| authorships[23].institutions[1].lineage | https://openalex.org/I4210164624, https://openalex.org/I98677209 |
| authorships[23].institutions[1].country_code | GB |
| authorships[23].institutions[1].display_name | The Queen's Medical Research Institute |
| authorships[23].institutions[2].id | https://openalex.org/I98677209 |
| authorships[23].institutions[2].ror | https://ror.org/01nrxwf90 |
| authorships[23].institutions[2].type | education |
| authorships[23].institutions[2].lineage | https://openalex.org/I98677209 |
| authorships[23].institutions[2].country_code | GB |
| authorships[23].institutions[2].display_name | University of Edinburgh |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Clare Pridans |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom, University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom |
| authorships[24].author.id | https://openalex.org/A5052531911 |
| authorships[24].author.orcid | https://orcid.org/0000-0002-7717-7897 |
| authorships[24].author.display_name | Elisa Gomez Perdiguero |
| authorships[24].countries | FR |
| authorships[24].affiliations[0].institution_ids | https://openalex.org/I157536573, https://openalex.org/I4387153797 |
| authorships[24].affiliations[0].raw_affiliation_string | Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France |
| authorships[24].institutions[0].id | https://openalex.org/I4387153797 |
| authorships[24].institutions[0].ror | https://ror.org/02af93v77 |
| authorships[24].institutions[0].type | facility |
| authorships[24].institutions[0].lineage | https://openalex.org/I1294671590, https://openalex.org/I157536573, https://openalex.org/I4387153797 |
| authorships[24].institutions[0].country_code | |
| authorships[24].institutions[0].display_name | Biologie du Développement et Cellules Souches |
| authorships[24].institutions[1].id | https://openalex.org/I157536573 |
| authorships[24].institutions[1].ror | https://ror.org/0495fxg12 |
| authorships[24].institutions[1].type | nonprofit |
| authorships[24].institutions[1].lineage | https://openalex.org/I157536573 |
| authorships[24].institutions[1].country_code | FR |
| authorships[24].institutions[1].display_name | Institut Pasteur |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Elisa Gomez-Perdiguero |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | Institut Pasteur, Unité Macrophages et Développement de l'Immunité, Département de Biologie du Développement et Cellules Souches, Paris, France |
| authorships[25].author.id | https://openalex.org/A5101948097 |
| authorships[25].author.orcid | https://orcid.org/0000-0002-8149-0747 |
| authorships[25].author.display_name | Christian Schulz |
| authorships[25].countries | DE |
| authorships[25].affiliations[0].institution_ids | https://openalex.org/I8204097 |
| authorships[25].affiliations[0].raw_affiliation_string | Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| authorships[25].affiliations[1].institution_ids | https://openalex.org/I4210127591 |
| authorships[25].affiliations[1].raw_affiliation_string | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany |
| authorships[25].affiliations[2].institution_ids | https://openalex.org/I8204097 |
| authorships[25].affiliations[2].raw_affiliation_string | Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany |
| authorships[25].institutions[0].id | https://openalex.org/I4210127591 |
| authorships[25].institutions[0].ror | https://ror.org/031t5w623 |
| authorships[25].institutions[0].type | facility |
| authorships[25].institutions[0].lineage | https://openalex.org/I4210127591, https://openalex.org/I4411590659 |
| authorships[25].institutions[0].country_code | DE |
| authorships[25].institutions[0].display_name | German Centre for Cardiovascular Research |
| authorships[25].institutions[1].id | https://openalex.org/I8204097 |
| authorships[25].institutions[1].ror | https://ror.org/05591te55 |
| authorships[25].institutions[1].type | education |
| authorships[25].institutions[1].lineage | https://openalex.org/I8204097 |
| authorships[25].institutions[1].country_code | DE |
| authorships[25].institutions[1].display_name | Ludwig-Maximilians-Universität München |
| authorships[25].author_position | last |
| authorships[25].raw_author_name | Christian Schulz |
| authorships[25].is_corresponding | True |
| authorships[25].raw_affiliation_strings | DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 806 Munich, Germany, Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig Maximilian University, 81377 Munich, Germany, Medical Clinic I., Department of Cardiology, University Hospital, Ludwig Maximilian University, 8377 Munich, Germany |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.05.08.539799.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-23T05:10:03.516525 |
| primary_topic.id | https://openalex.org/T11962 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9988999962806702 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2705 |
| primary_topic.subfield.display_name | Cardiology and Cardiovascular Medicine |
| primary_topic.display_name | Cardiac Fibrosis and Remodeling |
| related_works | https://openalex.org/W3183948672, https://openalex.org/W3173606202, https://openalex.org/W3110381201, https://openalex.org/W2948807893, https://openalex.org/W2935909890, https://openalex.org/W2899084033, https://openalex.org/W2778153218, https://openalex.org/W2758277628, https://openalex.org/W2748952813, https://openalex.org/W1531601525 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2023.05.08.539799 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.05.08.539799.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2023.05.08.539799 |
| primary_location.id | doi:10.1101/2023.05.08.539799 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/06/19/2023.05.08.539799.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2023.05.08.539799 |
| publication_date | 2023-05-09 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W3151068974, https://openalex.org/W4210289680, https://openalex.org/W3099810371, https://openalex.org/W2904624968, https://openalex.org/W2805322110, https://openalex.org/W2102100445, https://openalex.org/W1973705669, https://openalex.org/W2132828152, https://openalex.org/W2163470859, https://openalex.org/W1893639294, https://openalex.org/W2095214727, https://openalex.org/W2902050841, https://openalex.org/W4205428045, https://openalex.org/W2160582541, https://openalex.org/W1968630647, https://openalex.org/W2010484682, https://openalex.org/W1038738783, https://openalex.org/W2547458640, https://openalex.org/W2148898943, https://openalex.org/W2529694725, https://openalex.org/W2142242761, https://openalex.org/W2065210647, https://openalex.org/W2271392345, https://openalex.org/W2141870249, https://openalex.org/W2997280954, https://openalex.org/W2107915827, https://openalex.org/W2157758580, https://openalex.org/W2781853139, https://openalex.org/W2605696370, https://openalex.org/W2936121316, https://openalex.org/W3132661792, https://openalex.org/W2937503078, https://openalex.org/W2038970416, https://openalex.org/W2182520417, https://openalex.org/W2138207763, https://openalex.org/W2179438025, https://openalex.org/W2125065061, https://openalex.org/W2506892818, https://openalex.org/W2889326414, https://openalex.org/W2146163621, https://openalex.org/W3112994859, https://openalex.org/W2104010513, https://openalex.org/W2135647797, https://openalex.org/W3086660393, https://openalex.org/W2781770015, https://openalex.org/W2734437592, https://openalex.org/W2069406253, https://openalex.org/W2795177242, https://openalex.org/W2154053567, https://openalex.org/W2902377348, https://openalex.org/W3207283439, https://openalex.org/W2964143382, https://openalex.org/W2855400427, https://openalex.org/W2479827938, https://openalex.org/W2079554961, https://openalex.org/W2010876644, https://openalex.org/W1892455321, https://openalex.org/W2109627278, https://openalex.org/W2795559730, https://openalex.org/W2103441770, https://openalex.org/W2148771210, https://openalex.org/W2752390937, https://openalex.org/W2048820188, https://openalex.org/W3086629096, https://openalex.org/W1974980613, https://openalex.org/W2998670042, https://openalex.org/W2994150660, https://openalex.org/W4295898742, https://openalex.org/W4226426895 |
| referenced_works_count | 69 |
| abstract_inverted_index.a | 53, 59 |
| abstract_inverted_index.In | 118, 151 |
| abstract_inverted_index.We | 37 |
| abstract_inverted_index.an | 142 |
| abstract_inverted_index.in | 5, 15, 32, 46, 52, 64, 69, 100, 110, 180 |
| abstract_inverted_index.of | 23, 27, 30, 58, 72, 82, 91, 126, 148, 183 |
| abstract_inverted_index.to | 85, 102, 124, 141, 176 |
| abstract_inverted_index.I/R | 50, 138, 168 |
| abstract_inverted_index.and | 7, 42, 48, 75, 104, 129, 139, 146 |
| abstract_inverted_index.are | 3 |
| abstract_inverted_index.has | 10 |
| abstract_inverted_index.led | 123, 140 |
| abstract_inverted_index.our | 21 |
| abstract_inverted_index.the | 24, 65, 80, 86, 96, 181 |
| abstract_inverted_index.This | 133 |
| abstract_inverted_index.been | 11 |
| abstract_inverted_index.both | 127 |
| abstract_inverted_index.cell | 98 |
| abstract_inverted_index.here | 38 |
| abstract_inverted_index.role | 26 |
| abstract_inverted_index.size | 145, 166 |
| abstract_inverted_index.with | 13 |
| abstract_inverted_index.CSF1R | 121 |
| abstract_inverted_index.Csf1r | 66 |
| abstract_inverted_index.These | 170 |
| abstract_inverted_index.after | 49, 137, 167 |
| abstract_inverted_index.locus | 67 |
| abstract_inverted_index.size. | 117 |
| abstract_inverted_index.their | 16 |
| abstract_inverted_index.which | 9 |
| abstract_inverted_index.while | 161 |
| abstract_inverted_index.(FIRE) | 63 |
| abstract_inverted_index.heart. | 88 |
| abstract_inverted_index.immune | 97 |
| abstract_inverted_index.injury | 34, 51, 103 |
| abstract_inverted_index.tissue | 44 |
| abstract_inverted_index.Cardiac | 1 |
| abstract_inverted_index.Despite | 18 |
| abstract_inverted_index.Genomic | 56 |
| abstract_inverted_index.ablated | 43 |
| abstract_inverted_index.absence | 71, 90 |
| abstract_inverted_index.adverse | 135 |
| abstract_inverted_index.altered | 95 |
| abstract_inverted_index.cardiac | 112, 149, 159 |
| abstract_inverted_index.context | 182 |
| abstract_inverted_index.effects | 175 |
| abstract_inverted_index.element | 62 |
| abstract_inverted_index.induced | 105 |
| abstract_inverted_index.infarct | 116, 144, 165 |
| abstract_inverted_index.injury. | 169 |
| abstract_inverted_index.manner. | 55 |
| abstract_inverted_index.precise | 25 |
| abstract_inverted_index.remains | 35 |
| abstract_inverted_index.subsets | 29 |
| abstract_inverted_index.without | 78, 114 |
| abstract_inverted_index.ABSTRACT | 0, 187 |
| abstract_inverted_index.Specific | 89 |
| abstract_inverted_index.deletion | 57 |
| abstract_inverted_index.distinct | 173 |
| abstract_inverted_index.findings | 171 |
| abstract_inverted_index.impaired | 111 |
| abstract_inverted_index.lineages | 41 |
| abstract_inverted_index.resident | 73, 128, 153 |
| abstract_inverted_index.response | 101 |
| abstract_inverted_index.resulted | 68 |
| abstract_inverted_index.specific | 70 |
| abstract_inverted_index.summary, | 152 |
| abstract_inverted_index.GRAPHICAL | 186 |
| abstract_inverted_index.affecting | 79 |
| abstract_inverted_index.attribute | 172 |
| abstract_inverted_index.augmented | 134 |
| abstract_inverted_index.contrast, | 119 |
| abstract_inverted_index.crosstalk | 99 |
| abstract_inverted_index.depletion | 125 |
| abstract_inverted_index.determine | 164 |
| abstract_inverted_index.different | 28, 177 |
| abstract_inverted_index.extensive | 19 |
| abstract_inverted_index.function. | 150 |
| abstract_inverted_index.improving | 158 |
| abstract_inverted_index.increased | 143 |
| abstract_inverted_index.infarcted | 87 |
| abstract_inverted_index.ontogeny. | 17 |
| abstract_inverted_index.phenotype | 6 |
| abstract_inverted_index.recruited | 130, 162 |
| abstract_inverted_index.research, | 20 |
| abstract_inverted_index.responses | 157 |
| abstract_inverted_index.resulting | 109 |
| abstract_inverted_index.associated | 12 |
| abstract_inverted_index.beneficial | 174 |
| abstract_inverted_index.continuous | 120 |
| abstract_inverted_index.functions, | 8 |
| abstract_inverted_index.inhibition | 122 |
| abstract_inverted_index.macrophage | 40, 131, 178 |
| abstract_inverted_index.myocardial | 184 |
| abstract_inverted_index.neutrophil | 107 |
| abstract_inverted_index.regulatory | 61 |
| abstract_inverted_index.differences | 14 |
| abstract_inverted_index.homeostasis | 47 |
| abstract_inverted_index.homeostatic | 74 |
| abstract_inverted_index.incomplete. | 36 |
| abstract_inverted_index.infarction. | 185 |
| abstract_inverted_index.influencing | 115 |
| abstract_inverted_index.macrophages | 2, 31, 45, 84, 94, 154, 163 |
| abstract_inverted_index.orchestrate | 155 |
| abstract_inverted_index.populations | 179 |
| abstract_inverted_index.recruitment | 81 |
| abstract_inverted_index.remodelling | 113, 136 |
| abstract_inverted_index.fms-intronic | 60 |
| abstract_inverted_index.heterogenous | 4 |
| abstract_inverted_index.homeostatic, | 92 |
| abstract_inverted_index.inflammatory | 156 |
| abstract_inverted_index.investigated | 39 |
| abstract_inverted_index.macrophages, | 77 |
| abstract_inverted_index.populations. | 132 |
| abstract_inverted_index.remodelling, | 160 |
| abstract_inverted_index.deterioration | 147 |
| abstract_inverted_index.polarization, | 108 |
| abstract_inverted_index.understanding | 22 |
| abstract_inverted_index.CSF1R-dependent | 54 |
| abstract_inverted_index.proinflammatory | 106 |
| abstract_inverted_index.monocyte-derived | 83 |
| abstract_inverted_index.antigen-presenting | 76 |
| abstract_inverted_index.ischemia/reperfusion | 33 |
| abstract_inverted_index.monocyte-independent | 93 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5101948097 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 26 |
| corresponding_institution_ids | https://openalex.org/I4210127591, https://openalex.org/I8204097 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.67479271 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |