Research Square (Research Square)
Residues in HLA class I that Account for Variation of the HIV Host Response Distinctly Modulate Interactions with TCR and KIRs
September 2022 • Rhoda Tano-Menka, Nishant K. Singh, Itai Muzhingi, Xiaolong Li, Michael V Mandanas, Clarety Kaseke, Angela Zhang, Funsho Ogunshola, Liza Vecchiarello…
Abstract Polymorphisms in human leukocyte antigen ( HLA ) genes strongly influence outcomes to HIV infection. However, the underlying mechanisms by which certain alleles mediate protection is not well understood. Here we systematically investigate residues within HLA class I molecules (at positions 67, 70, 97 and 156) that have been demonstrated by genetic studies to explain the observed variation of HLA class I alleles on HIV infection. Through a detailed assessment of the protective HLA-B*5701 allele, we find th…