Resolution in cryogenic solid state NMR : Challenges and solutions
Article Swipe
Ivan V. Sergeyev
,
Keith J. Fritzsching
,
Rivkah Rogawski
,
Ann E. McDermott
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/pro.4803
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/pro.4803
NMR at cryogenic temperatures has the potential to provide rich site‐specific details regarding biopolymer structure, function, and mechanistic intermediates. Broad spectral lines compared with room temperature NMR can sometimes present practical challenges. A number of hypotheses regarding the origins of line broadening are explored. One frequently considered explanation is the presence of inhomogeneous conformational distributions. Possibly these arise when the facile characteristic motions that occur near room temperature become dramatically slower or “frozen out” at temperatures below the solvent phase change. Recent studies of low temperature spectra harness the distributions in properties in these low temperature spectra to uncover information regarding the conformational ensembles that drive biological function.
Related Topics
Concepts
Cryogenic temperature
Biopolymer
Spectral line
NMR spectra database
Chemical physics
Function (biology)
Resolution (logic)
Chemistry
Line width
Materials science
Polymer
Physics
Computer science
Organic chemistry
Optics
Biology
Evolutionary biology
Astronomy
Artificial intelligence
Composite material
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/pro.4803
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4803
- OA Status
- bronze
- Cited By
- 8
- References
- 65
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387692248
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4387692248Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/pro.4803Digital Object Identifier
- Title
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Resolution in cryogenic solid state
NMR : Challenges and solutionsWork title - Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-10-17Full publication date if available
- Authors
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Ivan V. Sergeyev, Keith J. Fritzsching, Rivkah Rogawski, Ann E. McDermottList of authors in order
- Landing page
-
https://doi.org/10.1002/pro.4803Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4803Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4803Direct OA link when available
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Cryogenic temperature, Biopolymer, Spectral line, NMR spectra database, Chemical physics, Function (biology), Resolution (logic), Chemistry, Line width, Materials science, Polymer, Physics, Computer science, Organic chemistry, Optics, Biology, Evolutionary biology, Astronomy, Artificial intelligence, Composite materialTop concepts (fields/topics) attached by OpenAlex
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8Total citation count in OpenAlex
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2025: 5, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
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65Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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