Resolution of otitis media in a humanized mouse model Article Swipe
Ye Lin Son
,
Kwang Pak
,
Nada Muradagha
,
Kyung Wook Heo
,
Anke Leichtle
,
Arwa Kurabi
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2022.958540
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2022.958540
Otitis media (OM) is one of the largest public health problems of children and has devastating impacts in developing countries. The substantial medical and human costs involved have led to research to understand the disease and improve treatment. Animal models of OM have yielded critical information about the immune, inflammatory and genetic mechanisms of OM. However, it is important to link animal studies to human immune and inflammatory responses. In recent years, “humanized” mice have become a valuable tool to study the human immune system in an animal model. Here we describe the first use of humanized mice to study OM. We demonstrate that humanized mice with a sufficient degree of engraftment recapitulate a normal middle ear (ME) inflammatory response to bacterial infection, including the recruitment of human immune cells, and exhibit normal recovery. Moreover, these animals exhibit regulated expression of human-specific immune and inflammatory genes in the ME. In contrast, mice with insufficient engraftment fail to resolve OM. This model has many potential uses in OM research, including using hematopoietic stem cells from patients with differing degrees of OM susceptibility, to understand the role of human immune responses in proneness to this common childhood disease.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fgene.2022.958540
- https://www.frontiersin.org/articles/10.3389/fgene.2022.958540/pdf
- OA Status
- gold
- Cited By
- 4
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4308726199
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4308726199Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fgene.2022.958540Digital Object Identifier
- Title
-
Resolution of otitis media in a humanized mouse modelWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-09Full publication date if available
- Authors
-
Ye Lin Son, Kwang Pak, Nada Muradagha, Kyung Wook Heo, Anke Leichtle, Arwa KurabiList of authors in order
- Landing page
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https://doi.org/10.3389/fgene.2022.958540Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fgene.2022.958540/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fgene.2022.958540/pdfDirect OA link when available
- Concepts
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Immune system, Humanized mouse, Otitis, Immunology, Disease, Biology, Human disease, Stem cell, Inflammation, Haematopoiesis, Animal model, Medicine, Genetics, Pathology, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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61Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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