Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy: a case report Article Swipe
Daniel S. Kluger
,
Tim Erdbrügger
,
Christina Stier
,
Malte B. Höltershinken
,
Omid Abbasi
,
Martina Saltafossi
,
Kanjana Unnwongse
,
Tim Wehner
,
Jörg Wellmer
,
Joachim Groß
,
Carsten H. Wolters
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s43856-025-00811-z
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s43856-025-00811-z
Background Brain activity in focal epilepsy is marked by a pronounced excitation-inhibition (E:I) imbalance and interictal epileptiform discharges (IEDs) observed in periods between recurrent seizures. As a marker of E:I balance, aperiodic neural activity and its underlying 1/f characteristic reflect the dynamic interplay of excitatory and inhibitory currents. Recent studies have independently assessed 1/f changes both in epilepsy and in the context of body-brain interactions in neurotypical individuals where the respiratory rhythm has emerged as a potential modulator of excitability states in the brain. Methods Here, we investigate respiration phase-locked modulations of E:I balance and their involvement in the timing of spike discharges in a case report of a 25 year-old focal epilepsy patient using magnetoencephalography (MEG). Results We show that i) respiration differentially modulates E:I balance in focal epilepsy compared to N = 40 neurotypical controls and ii) IED timing depends on both excitability and respiratory states. Conclusions These findings overall suggest an intricate interplay of respiration phase-locked changes in excitation and the consequential susceptibility for IED generation and we hope they will spark interest in subsequent work on body-brain coupling and E:I balance in epilepsy.
Related Topics
Concepts
Epilepsy
Magnetoencephalography
Ictal
Neurotypical
Neuroscience
Context (archaeology)
Balance (ability)
Excitatory postsynaptic potential
Epileptogenesis
Electroencephalography
Psychology
Medicine
Inhibitory postsynaptic potential
Biology
Autism
Developmental psychology
Autism spectrum disorder
Paleontology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s43856-025-00811-z
- https://www.nature.com/articles/s43856-025-00811-z.pdf
- OA Status
- gold
- Cited By
- 4
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409318275
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409318275Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s43856-025-00811-zDigital Object Identifier
- Title
-
Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy: a case reportWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-04-10Full publication date if available
- Authors
-
Daniel S. Kluger, Tim Erdbrügger, Christina Stier, Malte B. Höltershinken, Omid Abbasi, Martina Saltafossi, Kanjana Unnwongse, Tim Wehner, Jörg Wellmer, Joachim Groß, Carsten H. WoltersList of authors in order
- Landing page
-
https://doi.org/10.1038/s43856-025-00811-zPublisher landing page
- PDF URL
-
https://www.nature.com/articles/s43856-025-00811-z.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s43856-025-00811-z.pdfDirect OA link when available
- Concepts
-
Epilepsy, Magnetoencephalography, Ictal, Neurotypical, Neuroscience, Context (archaeology), Balance (ability), Excitatory postsynaptic potential, Epileptogenesis, Electroencephalography, Psychology, Medicine, Inhibitory postsynaptic potential, Biology, Autism, Developmental psychology, Autism spectrum disorder, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
- References (count)
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43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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