Response to Biologics in Patients With Early-Onset Treatment-Naïve Metastatic Colorectal Cancer—An Aide et Recherche en Cancérologie Digestive Database Analysis Article Swipe
Zhaohui Jin
,
Jesse G. Dixon
,
Joleen M. Hubbard
,
Cathy Eng
,
Christopher H. Lieu
,
Jean‐Yves Douillard
,
Richard Adams
,
Tim Maughan
,
Eric Van Cutsem
,
Alan P. Venook
,
Heinz‐Josef Lenz
,
Volker Heinemann
,
Sebastian Stintzing
,
Leonard B. Saltz
,
H.J.E-V. Schmoll
,
Charles S. Fuchs
,
J. Randolph Hecht
,
Alfredo Falcone
,
Eduardo Díaz‐Rubio
,
Cornelis J. A. Punt
,
Niall C. Tebbutt
,
Carsten Bokemeyer
,
Benoist Chibaudel
,
John Zalcberg
,
Takayuki Yoshino
,
Aimery de Gramont
,
Qian Shi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1200/oa-24-00080
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1200/oa-24-00080
PURPOSE Colorectal cancer (CRC) incidence and mortality have decreased since the 1970s, but the incidence in young adults (<50 years, named early-onset CRC [eoCRC]) has been increasing. PATIENTS AND METHODS Individual patient data on 13,365 patients with metastatic CRC enrolled between 2000 and 2012 in 17 first-line randomized trials in the Aide et Recherche en Cancérologie Digestive database were pooled. The distribution of demographics, clinicopathologic features, biomarkers, and outcome data were summarized and compared by age groups. Progression-free survival (PFS) and overall survival (OS) were assessed by Kaplan-Meier curves and Cox models stratified by treatment arms within studies, adjusting for potential confounders. Predictive value of age group on clinical outcomes was evaluated by testing interaction effect between treatment and age variables. RESULTS Overall, 2,045 patients with eoCRC (median age, 42.5) and 11,320 patients with average-onset CRC (aoCRC; median age, 63.8) were included in this analysis. Within the eoCRC population, treatment with bevacizumab in addition to chemotherapy improved PFS (9.9 v 6.8 months; hazard ratio [HR], 0.66 [95% CI, 0.54 to 0.80]; P < .0001), which was similar to the findings in aoCRC population (9.4 v 7.3 months; HR, 0.73 [95% CI, 0.67 to 0.80]; P < .001; interaction P = .5415). However, epithelial growth factor receptor inhibitor (EGFRi) did not improve PFS in RAS wild-type (WT) patients with eoCRC who had left-sided primary tumors (8.3 v 8.9 months; HR, 1.20 [95% CI, 0.81 to 1.77]; P = .36), whereas EGFRi significantly improved PFS in the aoCRC population (9.9 v 8.5 months; HR, 0.74 [95% CI, 0.64 to 0.86]; P < .0001; interaction P = .083). CONCLUSION Treatment-naïve patients with metastatic eoCRC appear to derive similar benefit from bevacizumab as patients with aoCRC. However, patients with eoCRC with left-sided RAS/RAF WT tumors did not appear to derive benefit from first-line EGFRi.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1200/oa-24-00080
- OA Status
- diamond
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412125712
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412125712Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1200/oa-24-00080Digital Object Identifier
- Title
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Response to Biologics in Patients With Early-Onset Treatment-Naïve Metastatic Colorectal Cancer—An Aide et Recherche en Cancérologie Digestive Database AnalysisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-07-01Full publication date if available
- Authors
-
Zhaohui Jin, Jesse G. Dixon, Joleen M. Hubbard, Cathy Eng, Christopher H. Lieu, Jean‐Yves Douillard, Richard Adams, Tim Maughan, Eric Van Cutsem, Alan P. Venook, Heinz‐Josef Lenz, Volker Heinemann, Sebastian Stintzing, Leonard B. Saltz, H.J.E-V. Schmoll, Charles S. Fuchs, J. Randolph Hecht, Alfredo Falcone, Eduardo Díaz‐Rubio, Cornelis J. A. Punt, Niall C. Tebbutt, Carsten Bokemeyer, Benoist Chibaudel, John Zalcberg, Takayuki Yoshino, Aimery de Gramont, Qian ShiList of authors in order
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https://doi.org/10.1200/oa-24-00080Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://doi.org/10.1200/oa-24-00080Direct OA link when available
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Medicine, Colorectal cancer, Cancer, Internal medicine, Oncology, Database, Computer scienceTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| publication_date | 2025-07-01 |
| publication_year | 2025 |
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