REST-dependent glioma progression occurs independently of the repression of the long non-coding RNA HAR1A Article Swipe
Ella V. Waters
,
Perla Pucci
,
Ruman Rahman
,
Anna P. Yatsyshyna
,
Harry Porter
,
Mark C. Hirst
,
Radka Gromnicova
,
Igor Kraev
,
Vera Mongiardini
,
Benedetto Grimaldi
,
Jon P. Golding
,
Helen L. Fillmore
,
Balázs Győrffy
,
Priyadarsini Gangadharannambiar
,
Christos N. Velanis
,
Christopher J. Heath
,
Francesco Crea
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0312237
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0312237
The long non-coding RNA (lncRNA), HAR1A is emerging as a putative tumour suppressor. In non-neoplastic brain cells, REST suppresses HAR1A expression. In gliomas REST acts as an oncogene and is a potential therapeutic target. It is therefore conceivable that REST promotes glioma progression by down-regulating HAR1A . To test this hypothesis, glioma clinical databases were analysed to study: (I) HAR1A / REST correlation; (II) HAR1A and REST prognostic role; (III) molecular pathways associated with these genes. HAR1A expression and subcellular localization were studied in glioblastoma and paediatric glioma cells. REST function was also studied in these cells, by observing the effects of gene silencing on: (I) HAR1A expression; (II) cancer cell proliferation, apoptosis, migration; (III) expression of neural differentiation genes. The same phenotypes (and cell morphology) were studied in HAR1A overexpressing cells. Our results show that REST and HAR1A are negatively correlated in gliomas. Higher REST expression predicts worse prognosis in low-grade gliomas (the opposite is true for HAR1A ). REST -silencing induces HAR1A upregulation. HAR1A is primarily detected in the nucleus. REST -silencing dramatically reduces cell proliferation and induces apoptosis, but HAR1A overexpression has no major effect on investigated cell phenotypes. We also show that REST regulates the expression of neural differentiation genes and that its oncogenic function is primarily HAR1A -independent.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0312237
- OA Status
- gold
- References
- 29
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4404790176Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0312237Digital Object Identifier
- Title
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REST-dependent glioma progression occurs independently of the repression of the long non-coding RNA HAR1AWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-27Full publication date if available
- Authors
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Ella V. Waters, Perla Pucci, Ruman Rahman, Anna P. Yatsyshyna, Harry Porter, Mark C. Hirst, Radka Gromnicova, Igor Kraev, Vera Mongiardini, Benedetto Grimaldi, Jon P. Golding, Helen L. Fillmore, Balázs Győrffy, Priyadarsini Gangadharannambiar, Christos N. Velanis, Christopher J. Heath, Francesco CreaList of authors in order
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https://doi.org/10.1371/journal.pone.0312237Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1371/journal.pone.0312237Direct OA link when available
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Gene silencing, Rest (music), Glioma, Biology, Cancer research, Oncogene, Phenotype, Cell growth, Gene, Cell, Apoptosis, Gene expression, Cell cycle, Genetics, Medicine, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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