Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes Article Swipe

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Varina L. Boerwinkle , Mary A. Nowlen , Jesus E. Vazquez , Martin Arhin , William Reuther , Emilio G. Cediel , Patrick J. McCarty , Iliana Manjón , Jubran H. Jubran , Ashley Guest , Kirsten D. Gillette , Frances M. Nowlen , Andrew R. Pines , Masoomeh Kazemi , Bahjat F. Qaqish ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.17615/5sn8-3877

Resting-state functional MRI (rs-fMRI) may localize the seizure onset zone (SOZ) for epilepsy surgery, when compared to intracranial EEG and surgical outcomes, per a prior meta-analysis. Our goals were to further characterize this agreement, by broadening the queried rs-fMRI analysis subtypes, comparative modalities, and same-modality comparisons, hypothesizing SOZ-signal strength may overcome this heterogeneity. PubMed, Embase, Scopus, Web of Science, and Google Scholar between April 2010 and April 2020 via PRISMA guidelines for SOZ-to-established-modalities were screened. Odd ratios measured agreement between SOZ and other modalities. Fixed- and random-effects analyses evaluated heterogeneity of odd ratios, with the former evaluating differences in agreement across modalities and same-modality studies. In total, 9,550 of 14,384 were non-duplicative articles and 25 met inclusion criteria. Comparative modalities were EEG 7, surgical outcome 6, intracranial EEG 5, anatomical MRI 4, EEG-fMRI 2, and magnetoencephalography 1. Independent component analysis 9 and seed-based analysis 8 were top rs-fMRI methods. Study-level odds ratio heterogeneity in both the fixed- and random-effects analysis was significant (p < 0.001). Marked cross-modality and same-modality systematic differences in agreement between rs-fMRI and the comparator were present (p = 0.005 and p = 0.002), respectively, with surgical outcomes having higher agreement than EEG (p = 0.002) and iEEG (p = 0.007). The estimated population mean sensitivity and specificity were 0.91 and 0.09, with predicted values across studies ranging from 0.44 to 0.96 and 0.02 to 0.67, respectively. We evaluated centrality and heterogeneity in SOZ agreement between rs-fMRI and comparative modalities using a wider variety of rs-fMRI analyzing subtypes and comparative modalities, compared to prior. Strong evidence for between-study differences in the agreement odds ratio was shown by both the fixed- and the random-effects analyses, attributed to rs-fMRI analysis variability. Agreement with rs-fMRI differed by modality type, with surgical outcomes having higher agreement than EEG and iEEG. Overall, sensitivity was high, but specificity was low, which may be attributed in part to differences between other modalities.

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Resting state fMRI Functional connectivity Modalities Meta-analysis Psychology Neuroscience Audiology Medicine Internal medicine Sociology Social science

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Type: article
Language: en
Landing Page: https://doi.org/10.17615/5sn8-3877
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Title: Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes

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Language: en

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Publication year: 2024

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Publication date: 2024-12-17

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Authors: Varina L. Boerwinkle, Mary A. Nowlen, Jesus E. Vazquez, Martin Arhin, William Reuther, Emilio G. Cediel, Patrick J. McCarty, Iliana Manjón, Jubran H. Jubran, Ashley Guest, Kirsten D. Gillette, Frances M. Nowlen, Andrew R. Pines, Masoomeh Kazemi, Bahjat F. Qaqish

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Landing page: https://doi.org/10.17615/5sn8-3877

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Concepts: Resting state fMRI, Functional connectivity, Modalities, Meta-analysis, Psychology, Neuroscience, Audiology, Medicine, Internal medicine, Sociology, Social science

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abstract_inverted_index.anatomical	129
abstract_inverted_index.attributed	277, 310
abstract_inverted_index.broadening	35
abstract_inverted_index.centrality	232
abstract_inverted_index.comparator	177
abstract_inverted_index.evaluating	96
abstract_inverted_index.functional	1
abstract_inverted_index.guidelines	70
abstract_inverted_index.modalities	101, 119, 242
abstract_inverted_index.population	206
abstract_inverted_index.seed-based	142
abstract_inverted_index.systematic	169
abstract_inverted_index.Comparative	118
abstract_inverted_index.Independent	137
abstract_inverted_index.Study-level	149
abstract_inverted_index.comparative	41, 241, 252
abstract_inverted_index.differences	97, 170, 261, 314
abstract_inverted_index.modalities,	42, 253
abstract_inverted_index.modalities.	83, 317
abstract_inverted_index.sensitivity	208, 300
abstract_inverted_index.significant	161
abstract_inverted_index.specificity	210, 304
abstract_inverted_index.characterize	31
abstract_inverted_index.comparisons,	45
abstract_inverted_index.intracranial	17, 126
abstract_inverted_index.variability.	281
abstract_inverted_index.Resting-state	0
abstract_inverted_index.between-study	260
abstract_inverted_index.heterogeneity	89, 152, 234
abstract_inverted_index.hypothesizing	46
abstract_inverted_index.respectively,	187
abstract_inverted_index.respectively.	229
abstract_inverted_index.same-modality	44, 103, 168
abstract_inverted_index.cross-modality	166
abstract_inverted_index.heterogeneity.	52
abstract_inverted_index.meta-analysis.	25
abstract_inverted_index.random-effects	86, 158, 275
abstract_inverted_index.non-duplicative	111
abstract_inverted_index.magnetoencephalography	135
abstract_inverted_index.SOZ-to-established-modalities	72
cited_by_percentile_year
countries_distinct_count	0
institutions_distinct_count	15
citation_normalized_percentile.value	0.32644834
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False