Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity Article Swipe
Daniella C. Terenzi
,
Ehab Bakbak
,
Hwee Teoh
,
Aishwarya Krishnaraj
,
Pankaj Puar
,
Ori D. Rotstein
,
Francesco Cosentino
,
Ronald Goldenberg
,
Subodh Verma
,
David Hess
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/cvr/cvae016
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/cvr/cvae016
Ischaemic cardiovascular diseases, including peripheral and coronary artery disease, myocardial infarction, and stroke, remain major comorbidities for individuals with type 2 diabetes (T2D) and obesity. During cardiometabolic chronic disease (CMCD), hyperglycaemia and excess adiposity elevate oxidative stress and promote endothelial damage, alongside an imbalance in circulating pro-vascular progenitor cells that mediate vascular repair. Individuals with CMCD demonstrate pro-vascular ‘regenerative cell exhaustion’ (RCE) characterized by excess pro-inflammatory granulocyte precursor mobilization into the circulation, monocyte polarization towards pro-inflammatory vs. anti-inflammatory phenotype, and decreased pro-vascular progenitor cell content, impairing the capacity for vessel repair. Remarkably, targeted treatment with the sodium-glucose cotransporter-2 inhibitor (SGLT2i) empagliflozin in subjects with T2D and coronary artery disease, and gastric bypass surgery in subjects with severe obesity, has been shown to partially reverse these RCE phenotypes. SGLT2is and glucagon-like peptide-1 receptor agonists (GLP-1RAs) have reshaped the management of individuals with T2D and comorbid obesity. In addition to glucose-lowering action, both drug classes have been shown to induce weight loss and reduce mortality and adverse cardiovascular outcomes in landmark clinical trials. Furthermore, both drug families also act to reduce systemic oxidative stress through altered activity of overlapping oxidase and antioxidant pathways, providing a putative mechanism to augment circulating pro-vascular progenitor cell content. As SGLT2i and GLP-1RA combination therapies are emerging as a novel therapeutic opportunity for individuals with poorly controlled hyperglycaemia, potential additive effects in the reduction of oxidative stress may also enhance vascular repair and further reduce the ischaemic cardiovascular comorbidities associated with T2D and obesity.
Related Topics
Concepts
Medicine
Progenitor cell
Diabetes mellitus
Type 2 diabetes
Empagliflozin
Impaired glucose tolerance
Oxidative stress
Internal medicine
Endocrinology
Bioinformatics
Pharmacology
Stem cell
Biology
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/cvr/cvae016
- https://academic.oup.com/cardiovascres/article-pdf/119/18/2858/56697990/cvae016.pdf
- OA Status
- bronze
- Cited By
- 9
- References
- 165
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391894241
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391894241Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/cvr/cvae016Digital Object Identifier
- Title
-
Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-12-01Full publication date if available
- Authors
-
Daniella C. Terenzi, Ehab Bakbak, Hwee Teoh, Aishwarya Krishnaraj, Pankaj Puar, Ori D. Rotstein, Francesco Cosentino, Ronald Goldenberg, Subodh Verma, David HessList of authors in order
- Landing page
-
https://doi.org/10.1093/cvr/cvae016Publisher landing page
- PDF URL
-
https://academic.oup.com/cardiovascres/article-pdf/119/18/2858/56697990/cvae016.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/cardiovascres/article-pdf/119/18/2858/56697990/cvae016.pdfDirect OA link when available
- Concepts
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Medicine, Progenitor cell, Diabetes mellitus, Type 2 diabetes, Empagliflozin, Impaired glucose tolerance, Oxidative stress, Internal medicine, Endocrinology, Bioinformatics, Pharmacology, Stem cell, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
165Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| primary_location.pdf_url | https://academic.oup.com/cardiovascres/article-pdf/119/18/2858/56697990/cvae016.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Cardiovascular Research |
| primary_location.landing_page_url | https://doi.org/10.1093/cvr/cvae016 |
| publication_date | 2023-12-01 |
| publication_year | 2023 |
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