Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments Article Swipe
Evgenios Agathokleous
,
Damià Barceló
,
Michael Aschner
,
Ricardo Antunes Azevedo
,
Prosun Bhattacharya
,
David Costantini
,
G. Christopher Cutler
,
Alessandra De Marco
,
Anca Oana Docea
,
José G. Dórea
,
Stephen O. Duke
,
Thomas Efferth
,
Despo Fatta‐Kassinos
,
Vasileios Fotopoulos
,
Antonio Ginebreda
,
R. N. C. Guedes
,
A. Wallace Hayes
,
Ivo Iavicoli
,
Olga‐Ioanna Kalantzi
,
Takayoshi Koike
,
Demetrios Kouretas
,
Manish Kumar
,
José E. Manautou
,
Michael N. Moore
,
Elena Paoletti
,
Josep Peñuelas
,
Yolanda Picó
,
Russel J. Reíter
,
Ramin Rezaee
,
Jörg Rinklebe
,
Teresa Rocha‐Santos
,
Pierre Sicard
,
Christian Sonne
,
Christopher M. Teaf
,
Aristidis Tsatsakis
,
Constantine Vardavas
,
Wenjie Wang
,
Eddy Y. Zeng
,
Edward J. Calabrese
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1021/acs.est.2c02896
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1021/acs.est.2c02896
A great number of dose–response studies indicate that hormesis is a common phenomenon, occurring in numerous organisms exposed to singular or combined environmental stressors, such as pharmaceuticals, heavy metals, micro/nanoplastics, organic flame retardants, pesticides, and rare earths. (1−6) While biological responses to low exposure levels are often beneficial, exposure to doses below the no-observed-adverse-effect-level (NOAEL; hereafter subthreshold doses) does not always translate to beneficial responses. (2,4) For example, subthreshold contaminant doses can enhance the virulence of phytopathogenic microbes and promote the resistance of crop pests with significant implications for crop production. (2,7,8) Subthreshold contaminant exposures can also stimulate infectious animal/human pathogens and promote their resistance to antibiotics and other drugs, threatening long-term sustainability. Importantly, the hormetic function of common pathways that regulate cancer progress indicate that current regulatory standards may not protect adequately against cancer risks. (9−11)
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.est.2c02896
- OA Status
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- Cited By
- 33
- References
- 22
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4287833015Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acs.est.2c02896Digital Object Identifier
- Title
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Rethinking Subthreshold Effects in Regulatory Chemical Risk AssessmentsWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2022Year of publication
- Publication date
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2022-07-25Full publication date if available
- Authors
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Evgenios Agathokleous, Damià Barceló, Michael Aschner, Ricardo Antunes Azevedo, Prosun Bhattacharya, David Costantini, G. Christopher Cutler, Alessandra De Marco, Anca Oana Docea, José G. Dórea, Stephen O. Duke, Thomas Efferth, Despo Fatta‐Kassinos, Vasileios Fotopoulos, Antonio Ginebreda, R. N. C. Guedes, A. Wallace Hayes, Ivo Iavicoli, Olga‐Ioanna Kalantzi, Takayoshi Koike, Demetrios Kouretas, Manish Kumar, José E. Manautou, Michael N. Moore, Elena Paoletti, Josep Peñuelas, Yolanda Picó, Russel J. Reíter, Ramin Rezaee, Jörg Rinklebe, Teresa Rocha‐Santos, Pierre Sicard, Christian Sonne, Christopher M. Teaf, Aristidis Tsatsakis, Constantine Vardavas, Wenjie Wang, Eddy Y. Zeng, Edward J. CalabreseList of authors in order
- Landing page
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https://doi.org/10.1021/acs.est.2c02896Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://ddd.uab.cat/record/299892Direct OA link when available
- Concepts
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Library science, Geography, Forestry, Computer scienceTop concepts (fields/topics) attached by OpenAlex
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33Total citation count in OpenAlex
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2025: 4, 2024: 8, 2023: 18, 2022: 3Per-year citation counts (last 5 years)
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