Retinal and choroidal microvascular assessment of children receiving recombinant growth hormone therapy Article Swipe
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· 2024
· Open Access
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· DOI: https://doi.org/10.1186/s40942-024-00610-z
Background The purpose of this study is to evaluate the retinal and choroidal microvascular state in children with congenital isolated growth hormone deficiency (IGHD) and determine the effect of recombinant human growth hormone treatment on these structures compared with healthy controls. Methods The study included children with IGHD under recombinant human GH treatment as group one and another group of healthy controls. Both groups were examined using optical coherence tomography angiography (OCTA). Data concerning superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC), and retinal thickness were recorded. Results The study included two equal groups of 30 individuals. Both groups had no statistically significant differences in age, gender, weight, or spherical equivalent. However, subjects of group II were taller than those of group I ( p = 0.011). OCTA images of the SCP, DCP, and CC vessel density revealed statistically non-significant differences between the two groups. Conclusion Children receiving recombinant growth hormone therapy showed no changes in the retinal and choroidal microvasculature or macular thickness. Trial registration number 1094/03/2024 by Minia University Faculty of Medicine Institutional Review Board. Another registration number is UMIN000055654.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s40942-024-00610-z
- OA Status
- gold
- References
- 22
- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4404618086Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s40942-024-00610-zDigital Object Identifier
- Title
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Retinal and choroidal microvascular assessment of children receiving recombinant growth hormone therapyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-22Full publication date if available
- Authors
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Ismail Ahmed Nagib Omar, Yousra Samir Fadle, Nadia BakryList of authors in order
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https://doi.org/10.1186/s40942-024-00610-zPublisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1186/s40942-024-00610-zDirect OA link when available
- Concepts
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Retinal, IGHD, Plexus, Medicine, Recombinant DNA, Ophthalmology, Human growth hormone, Growth hormone, Fluorescein angiography, Growth hormone deficiency, Hormone, Internal medicine, Surgery, Biology, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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22Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| primary_location.raw_source_name | International Journal of Retina and Vitreous |
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| publication_date | 2024-11-22 |
| publication_year | 2024 |
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